Abstract
Purpose:
This study aimed to determine the suitability and optimal concentration of an ultrasonic contrast agent (SonoVue) for intralesional application during contrast-enhanced ultrasonography (CEUS).
Methods:
An in vitro model simulating an existing lesion in the anatomical environment of the mandibular ascending ramus was developed. After intralesional application, different SonoVue dilutions were compared with dilutions of an iodine-containing radiographic contrast agent (Imeron300) during cone-beam computed tomography.
Conclusions:
SonoVue provided a significant contrast effect for distinguishing the lesion from the surrounding soft tissue at dilutions of 1/10 and 1/20. Imeron300 showed a slightly superior contrast effect, even at dilutions of 1/50 and 1/100. However, CEUS using SonoVue in low dilutions seemed suitable for intralesional application in vitro. Further in vivo studies are required to validate the current results and determine the optimal contrast-agent concentration.
Keywords
Get full access to this article
View all access options for this article.
References
Supplementary Material
Please find the following supplemental material available below.
For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.
For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.
