Genetic Markers: Genes Involved in Human Hypertension

Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure: The fifth report of the Joint National Committee on Detection, Evaluation, and Treatment of High Blood Pressure (JNCV) Arch Intern Med 1993, 153:154–183.

Rice T Bouchard C Borecki IB Rao DC : Commingling and segregation analysis of blood pressure in a French-Canadian population Am J Hum Genet 1990, 46:37–44.

Perusse L Moll PP Sing CF : Evidence that a single gene with gender- and age-dependent effects influences systolic blood pressure determination in a population based sample Am J Hum Genet 1991, 49:94–105.

Lander ES Schork NJ : Genetic dissection of complex traits Science 1994, 265:2037–2048.

Lifton RP : Molecular genetics of human blood pressure variation Science 1996, 272:676–680.

Ward R : Familial aggregation and genetic epidemiology of blood pressure. In Hypertension: Pathophysiology, Diagnosis and Management. Edited by Laragh JH Brenner BM . New York: Raven Press; 1990:81–100.

Jeunemaitre X Soubrier F Kotelevtsev YV Lifton RR Williams CS Charru A : Molecular basis of human hypertension Cell 1992, 71:169–180.

Caulfield M Lavender P Farrall M Munroe P Lawson M Turner P : Linkage of the angiotensinogen gene to essential hypertension N Engl J Med 1994, 330:1629–1633.

Caulfield M Lavender P Newell-Price J Farral M Kamdar M Daniel H : Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans J Clin Invest 1995, 96:687–692.

Smithies O Madea N : Gene targeting approaches to complex genetic diseases: Atherosclerosis and essential hypertension Proc Natl Acad Sci USA 1995, 92:5266–5277.

Tanimoto K Sugiyama F Goto Y Ishida J Takimoto E Yagami K : Angiotensinogen-deficient mice with hypotension J Biol Chem 1994, 269:31334–31337.

Hegele RA Brunt JH Connelly PW : A polymorphism of the angiotensinogen gene associated with variation in blood pressure in a genetic isolate Circulation 1994, 90:2207–2212.

Hata A Namikawa C Sasaki M Sato K Nakamura T Tamura K : Angiotensinogen as a risk factor for essential hypertension in Japan J Clin Invest 1994, 93:1285–1287.

Ward K Hata A Jeunemaitre X Helin C Nelson L Namikawa C : A molecular variant of angiotensinogen associated with pre-eclampsia Nature Genet 1993, 4:59–61.

Jeunemaitre X Rigat B Charru A Houot AM Soubrier F Corvol P : Sib pair linkage analysis of renin gene haplotype in human essential hypertension Hum Genet 1992, 71:169–180.

Mullins JJ Peters J Ganten D : Fulminant hypertension in transgenic rats harboring the mouse Ren-2 gene Nature 1990, 344:541–544.

Jeunemaitre X Lifton RP Hunt SC Williams RR LaLouel JM : Absence of linkage between the angiotensin converting enzyme and human essential hypertension Nature Genet 1992, 1:72–75.

Krege JH John SWM Langenbach LL Hodgin JB Hagaman JR Bachman ES : Male-female differences in fertility and blood pressure in angiotensin-I converting enzyme-deficient mice Nature 1995, 375:146–148.

Rigat B Hubert C Alhenc-Gelas F Cambien F Corval P Soubrier F : An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half of the variance of serum enzyme levels J Clin Invest 1990, 86:1343–1346.

Zee RYL Lou Y-K Griffiths LR Morris BJ : Association of a polymorphism of the angiotensin-1 converting enzyme gene with essential hypertension Biochem Biophys Res Commun 1992, 184:9–15.

Morris BJ Zee RYL Schrader AP : Different frequencies of angiotensin-converting enzyme genotypes in older hypertensive individuals J Clin Invest 1994, 94:1085–1089.

Hiraga H Oshima T Watanabe M Ishida M Ishida T Shingu T : Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension Hypertension 1996, 27:569–572.

Harrap SB Davidson HR Connor JM Soubrier F Corvol P Fraser R : The angiotensin I converting enzyme gene and predisposition to high blood pressure Hypertension 1993, 21:455–460.

Lachurie M-L Azizi M Guyene T-T Alhenc-Gelas F Menard J : Angiotensin-converting enzyme gene polymorphism has no influence on the circulating renin-angiotensin-aldosterone system or blood pressure in normotensive subjects Circulation 1995, 92:2933–2942.

Higashimori K Zhao Y Higaki J Kamitani A Katsuya T Nakura J : Association analysis of a polymorphism of the angiotensin converting enzyme gene with essential hypertension in the Japanese population Biochem Biophys Res Commun 1993, 191:399–404.

Johnson AG Simons LA Friedlander Y Simons J Davis DR MaCallum J : I/D polymorphism of the angiotensin-converting enzyme gene does not predict isolated systolic or systolic-diastolic hypertension in the elderly J Hum Hypertens 1996, 10:167–169.

Kiema TR Kauma H Rantala AO Lilja M Reunanen A Kesaniema YA : Variation at the angiotensin-converting enzyme gene and angiotensinogen gene loci in relation to blood pressure Hypertension 1996, 28:1070–1075.

Ichiki T Labosky PA Shiota C Okuyama S Imagawa Y Fogo A : Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type-2 receptor Nature 1995, 377:748–750.

Bonnardeaux A Davies E Jeunemaitre X Fery I Charru A Clauser E : Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension Hypertension 1994, 24:63–69.

Castellano M Muiesan ML Beschi M Rizzoni D Cinelli A Salvetti M : Angiotensin II type 1 receptor A/C1166 polymorphism. Relationships with blood pressure and cardiovascular structure Hypertension 1996, 28:1076–1080.

Huang PL Huang Z Mashimo H Bloch KD Moskowitz MA Bevan JA : Hypertension in mice lacking the gene for endothelial nitric oxide synthase Nature 1995, 377:239–242.

Bonnardeaux A Nadaud S Charru A Jeunemaitre X Corvol P Soubrier F : Lack of evidence for linkage of the endothelial cell nitric oxide synthase gene to essential hypertension Circulation 1995, 91:96–102.

Margolis HS Horwitz D Pisano JJ Keiser HR : Urinary kallikrein excretion in hypertensive men: Relationships to sodium intake and sodium-retaining steroids Circ Res 1974, 35:820–825.

Berry TD Hasstedt SJ Hunt SC Wu LL Smith JB Ash KO : A gene for high urinary kallikrein may protect against hypertension in Utah kindreds Hypertension 1989, 13:3–8.

Chao J Chao L : Functional analysis of human tissue kallikrein in transgenic mouse models Hypertension 1996, 27:491–494.

Wang C Chao L Chao J : Direct gene delivery of human tissue kallikrein reduces blood pressure in spontaneously hypertensive rats. J Clin Invest 1995, 1710–1716.

Alfie ME Sigmon DH Pomposiello SI Carretero OA : Effect of high salt intake in mutant mice lacking bradykinin-B2 receptors Hypertension 1997, 29:483–487.

Cusi D Barlassina C Azzani T Casari G Citterio L Devoto M : Polymorphisms of α-adducin and salt sensitivity in patients with essential hypertension Lancet 1997, 340:1353–1357.