Genetic Markers: Genes Involved in Atherosclerosis

American Heart Association Heart and Stroke Facts: 1995 Statistical Supplement. Dallas, TX: American Heart Association; 1995.

Garg R Packer M Pitt B Yusuf S : Heart Failure in the 1990s: Evolution of a major public health problem in cardiovascular medicine J Am Coll Cardiol 1993, 22:3A–5A.

Ross R : The pathogenesis of atherosclerosis: A perspective for the 1990s Nature 1993, 362:801–809.

Castelli WR Garrison RJ Wilson PWF Abbott RD Kalousdian S Kannel B : Incidence of coronary heart disease and lipoprotein cholesterol levels: The Framingham study JAMA 1986, 256:2835–2838.

Castelli WP : The epidemiology of coronary heart disease: The Framingham study Am J Med 1984, 76:4–12.

Wilson PWF : Established risk factors and coronary artery disease: The Framingham study Am J Hypertens 1994, 7:7S–12S.

Hegele RA : Gene-environment interactions in atherosclerosis Mol Cell Biochem 1992, 113:177–186.

Marenberg ME Risch N Berkman LF Floderus B de-Faire U : Genetic susceptibility to death from coronary heart disease in a study of twins N Engl J Med 1994, 330:1041–1046.

Chamberlain JC Galton OJ : Genetic susceptibility to atherosclerosis Br Med Bull 1990, 46:917–940.

Hopkins PN Williams RR Kuida H Stults BM Hunt SC Barlow GK : Family history as an independent risk factor for incident coronary artery disease in a high risk cohort in Utah J Chron Dis 1986, 62:708–713.

Jorder LB Williams RR : Relation between family history of coronary artery disease and coronary risk variables Am J Cardiol 1988, 62:708–713.

The Genome Directory. Nature 1995, 277 (Suppl):175–298.

Adams MD Kerlavage AR Fleischmann RD Fuldner RA Bult CJ Lee NH : Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. The genome directory. Nature 377 (suppl):3–174.

Slack J Evans KA . The increased risk of death from ischemic heart disease in first degree relatives of 121 men and 96 women with ischemic heart disease. J Med Genet 1966, 3:239–257.

Berg K : Genetics of coronary artery disease Prog Med Genet 1983, 5:35–90.

Brenn T : Genetic and environmental effects on coronary heart disease risk factors in Northern Norway. The cardiovascular disease study in Finnmark Hum Genet 1994, 58:369–379.

Fuster V Badimon L Badimon J Chesebro JH : The pathogenesis of coronary artery disease and the acute coronary syndromes N Engl J Med 1992, 326:242–250.

Fuster V Badimon L Badimon J Chesebro JH : The pathogenesis of coronary artery disease and the acute coronary syndromes N Engl J Med 1992, 326:310–318.

van der Wall AC Becker AE van der Loos CM Das PK : Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology Circulation 1994, 89:36–44.

Lander ES Schork NJ : Genetic dissection of complex traits Science 1994, 265:2037–2048.

Lander E Kruglyak L : Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results Nature Genet 1995, 11:241–247.

Thompson G : Identifying complex disease genes: Progress and paradigms. Nature Genet 1994, 8:108–110.

Caulfield M Lavender P Farrall M Munroe P Lawson M Turner P : Linkage of the angiotensinogen gene to essential hypertension N Engl J Med 1994, 330:1629–1633.

Field LL Tobias R Magnus T : A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus Nature Genet 1994, 8:189–194.

Davies JL Kawaguchi Y Bennet ST Copeman JB Cordell HJ Pritchard LE : A genome-wide search for human type-1 diabetes susceptibility genes Nature 1994, 371:130–136.

Griendling KK Murphy TJ Wayne Alexander R : Molecular biology of the renin-angiotensin system Circulation 1993, 87:1816–1828.

Mombouli JV Vanhoutte PM : Kinins and endothelial control of vascular smooth muscle Annu Rev Pharm Toxicol 1995, 35:679–705.

Vaughan DE Lazos SA Tong K : Angiotensin II regulates the expression of plasminogen activator inhibitor-1 (PAI-1) in cultured endothelial cells. A potential link between the renin-angiotensin system and thrombosis J Clin Invest 1995, 95:995–1001.

James IM Dickenson EJ Burgoyne W Jeremy JY Barrados MA Mikhalidis DP : Treatment of hypertension with captopril: Preservation of regional blood flow and reduced platelet aggregation J Hum Hypertens 1988, 2:21–25.

Pieruzzi F Abassi ZA Keiser HR : Expression of renin-angiotensin system components in the heart, kidneys, and lungs of rats with experimental heart failure Circulation 1995, 92:3105–3112.

Passier RC Smits JF Weruyten MJ Studer R Drexler H Daemen MJ : Activation of angiotensin-converting enzyme expression in infarct zone following myocardial infarction Am J Physiol 1995, 269:H1268–1276.

Schunkert H Dzau VJ Tang SS Hirsch AT Apstein CS Lorell B : Increased rat cardiac angiotensin converting enzyme activity and mRNA levels in pressure overload left ventricular hypertrophy Circulation 1993, 87:1328–1339.

Hokimoto S Yasue H Fujimoto K Yamamoto H Nakao K Kaikita K : Expression of angiotensin-converting enzyme in remaining viable myocytes of human ventricles after myocardial infarction Circulation 1996, 94:1513–1518.

Tiret L Rigat B Visvikis S Breda C Corvol P Cambien F : Evidence, from combined segregation and linkage analysis that a variant of the angiotensin ∗I-converting enzyme (ACE) gene controls plasma angiotensin-1 converting enzyme levels Am J Hum Genet 1992, 51:197–205.

Rigat B Hubert C Alhenc-Gelas F Cambien F Corval P Soubrier F : An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half of the variance of serum enzyme levels J Clin Invest 1990, 86:1343–1346.

Danser AHJ Schalekamp MADH Bax WA van der Brink AM Saxena PR Riegger GAJ : Angiotensin-converting enzyme in the human heart: Effect of the deletion/insertion polymorphism Circulation 1995, 92:1387–1388.

Cambien F Poirier O Lecerf L Evans A Cambou JP Arveiler D : Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction Nature 1992, 359:641–644.

Beohar N Prather A Yu Q-T Raizner AE Kleiman NS Robert R : Angiotensin converting enzyme genotype DD is a risk factor for coronary artery disease J Invest Med 1995, 43:275–280.

Samani NJ Thompson JR O'Toole L Channer K Woods KL : A metaanalysis of the association of the deletion allele of the angiotensin-converting enzyme gene with myocardial infarction Circulation 1996, 94:708–712.

Yusuf S Pepine CJ Gares C Pouleur H Salem D Kostis J : Effect of enalapril on myocardial infarction and unstable angina in patients with low ejection fractions Lancet 1992, 340:1173–1178.

The SOLVD investigators: Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure N Engl J Med 1991, 325:293–302.

Sharpe N : The effects of angiotensin-1 converting enzyme inhibition on progression of atherosclerosis J Cardiovasc Pharmacol 1993, 22 (suppl 9):S9–S12.

Thompson SG Kienast J Pyke SDM Haverkate F van de Loo JCW : Homeostatic factors and the risk of MI or sudden death in patients with angina pectoris N Engl J Med 1995, 332:635–641.

Kanell WB Wolf PA Castelli WP Dagostino RB : Fibrinogen and risk of cardiovascular disease: The Framingham Study JAMA 1987, 258:1183–1186.

Henry I Uzan G Weil D Nicolas H Kaplan JC Marguerie C : The genes coding for Aa-, Bβ-, and γ-chains of fibrinogen map to 4q2 Am J Hum Genet 1984, 36:760–768.

Humphries SE Cook M Dubovitz M Stirling Y Meade TW : Role of genetic variation at the fibrinogen locus in determination of plasma fibrinogen concentrations Lancet 1987, i:1452–1455.

Scarabin P-Y Bara L Ricard S Poirier O Cambou JP Arveiler D : Genetic variation at the β-fibrinogen locus in relation to plasma fibrinogen concentrations and risk of MI: The ECTIM study Arterioscler Thromb 1993, 13:886–891.

Green F Hamsten A Blomback M Humphries S : The role of β-fibrinogen genotype in determining plasma fibrinogen levels in young survivors of MI and healthy controls from Sweden Thromb Haemost 1993, 70:915–920.

Yu Q-T Safavi F Roberts R Marian AJ : A potent genetic risk factor for coronary artery disease J Invest Med 1996, 44:154–159.

Behague I Poirier O Nicaud V Evans A Arveiler D Luc G : β fibrinogen gene polymorphism are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction (The ECTIM Study) Circulation 1996, 93:440–449.

Mackness MI Arrol S Durrington PN : Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein. FEBS Lett 1991, b:152–154.

McElveen J Mackness MI Colley CM Peard T Warner S Walker CH : Distribution of paraoxon hydrolysing activity in the serum of patients after myocardial infarction Clin Chem 1986, 32:671–673.

Furlong CE Richter RJ Seidel SJ Motulsky A : Role of genetic polymorphism of human plasma paraoxonase/arylesterase in hydrolysis of the insecticide metabolites chlorpyrifos oxon and paraoxon Am J Hum Genet 1988, 43:230–238.

Humbert R Adler DA Disteche CK Hassett C Omiecinski CJ Furlong CE : The molecular basis of the human serum paraoxonase activity polymorphism Nature Genet 1993, 3:73–76.

Adkins S Gan KN Mody M LaDu BN : Molecular basis for the polymorphic forms of human serum paraoxonase/arylesterase: Glutamine or arginine at position 191, for the respective A or B allozymes Am J Hum Genet 1993, 52: 598–608.

Ruiz J Blanche H James RW Garin MC Vaisse C Charpentier G : ∗Gln-Arg192 polymorphism of paraoxonase and coronary artery disease in type 2 diabetes Lancet 1995, 346:869–872.

Serrato M Marian A : A Variant of human paraoxonase/arylesterase (HUMPONA) gene is a risk factor for coronary artery disease J Clin Invest 1995, 96:3005–3008.

Weiss EJ Bray PF Schulman SP Kickler TS Grigoryev DN Kim H : Fibrinogen receptor polymorphism PI^A2: An inherited platelet risk factor for early coronary thrombotic events [abstract] Circulation 1995, 92:1–30.

Lefkovits J Plow EF Topol EJ : Platelet glycoprotein IIb/IIIa receptors in cardiovascular medicine N Engl J Med 1995, 332:1553–1559.

Rosa J-P Bray PF Gayet O Johnston GI Cook RG Jackson KW : Cloning of glycoprotein IIIa cDNA from human erythroleukemia cells and localization of the gene to chromosome 17 Blood 1988, 72:593–600.

Chen YP Djaffar I Pidard D Steiner B Cieutat AM Caen JP : Ser752rPro mutation in the cytoplasmic domain of integrin β³ subunit and defective activation of platelet integrin ∗α_IIb/β₃ (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. Proc Natl Acad Sci USA 1992, 89:10169–10173.

Newman PJ Derbes RS Aster RH : The human platelet alloantigens, PI^A1 and PI^A2, are associated with a leucine₃₃/proline₃₃ amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing J Clin Invest 1989, 83:1778–1781.

Marian AJ Brugada R Kleiman NS : Platelet glycoprotein IIIa PI^A polymorphism and myocardial infarction N Engl J Med 1996, 335:1071–1072.

Mayer EL Jacobsen DW Robinson K : Homocysteine and coronary atherosclerosis J Am Coll Cardiol 1996, 27:517–527.

Robinson K Mayer EL Miller DP Green R van Lente F Gupta A : Hyperhomocysteinemia and low pyridoxal phosphate: Common and independent reversible risk factors for coronary artery disease Circulation 1995, 92:2825–2830.

Stampfer MJ Malinow R Willett WC Newcomer LM Upson B Ulimann D : A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US Physicians JAMA 1992, 268:877–881.

Mudd SH Levy HL Skovby F : Disorders of transsulfuration. In The Metabolic Basis of Inherited Disease. Edited by Scriver CR Beaudet AL Sly WS Valle D . New York: McGraw-Hill; 1989:693–734.

Goyette P Summer JS Milos R Duncan AMV Rosenblatt DS Mathews RG : Human methylenetetrahydrofolate reductase: Isolation of cDNA, mapping and mutation identification Nature Genet 1994, 7:195–200.

Frosst P Blom HJ Milos R Goyette P Sheppard CA Mathews RG : A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase Nature Genet 1995, 10:111–113.

Goyette P Frosst P Rosenblatt DS Rozen R : Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlation in severe methylenetetrahydrofolate reductase deficiency Am J Hum Genet 1995, 56:1052–1059.

Jacques PF Bostom AG Williams RR Ellison RC Eckfeldt JH Rosenberg IH : Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations Circulation 1996, 93:7–9.

Kluijtmans LAJ van den Heuvel LPWJ Boers GHJ Frosst P Stevens EMB van Oost BA : Molecular genetic analysis in mild hyperhomocysteinemia: A common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease Am J Hum Genet 1996, 58:35–41.

Brugada R Marian AJ : A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction Atherosclerosis 1997, 128:107–112.

Ma J Stampfer MJ Hennekens CH Frosst P Seihub J Horsford J : Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians Circulation 1996, 94:2410–2416.

Schmitz C Lindpaintner K Verhoef P Gaziano JM Buring J : Genetic polymorphism of methylenetetrahydrofolate reductase and myocardial infarction: A case-control study Circulation 1996, 94:1812–1814.