Effect of Diabetes Mellitus on Outcome after Percutaneous Transluminal Coronary Angioplasty

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The Bypass Angioplasty Revascularization Investigation (BARI) Investigators: Comparison of coronary bypass surgery with angioplasty in patients with multivessel disease N Engl J Med 1996, 335:217–225. * This is the single largest randomized trial of CABG compared with PTCA for multivessel coronary artery disease. While there was no statistically significant difference in five-year survival between PTCA and CABG for the study group as a whole, subgroup analysis showed a highly significant survival benefit for diabetic patients initially randomized to CABG.

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Weintraub WS Ghazzal ZMB Cohen CL Douglas JS Jr Liberman HA Morris DC King SB III : Clinical implications of late proven patency after successful coronary angioplasty Circulation 1991, 84:572–582. ∗ Diabetes is established as an independent correlate of late cardiac events after PTCA, despite documented treatment-site patency up to 1 year after the procedure. Diabetes as a risk factor or marker for diffuse disease and more rapid progression of atherosclerosis is discussed, and the importance of complete revascularization is emphasized.

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