Physical activity can have a significant effect on plasma lipoproteins and lipoprotein metabolism. The effect of exercise on lipoprotein subclasses is often more significant than is reflected by routine measures of lipoprotein cholesterol. These effects have important clinical implications. Some apolipoprotein levels, with the exception of those of lipoprotein (a), are affected by physical activity. Changes in enzymes, as well as transfer protein, activity can help explain the exercise-induced changes in lipoprotein levels. Understanding the complex interaction between exercise and lipoprotein metabolism will enable the therapeutic use of exercise in the appropriate patient population.
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