Aims We hypothesized that If there is a chronobiologic variation in
the development of acute ischaemic events which is mainly attributed to the
tendency for thrombus formation in the morning hours, same time dependent
variations must also be seen in the development of ischaemic events after
percutaneous transluminal coronary angioplasty (PTCA) and PTCA with stent
implantation.
Methods Enrolled in this study were 349 consecutive patients with
single vessel disease and undergoing elective single vessel angioplasty.
Patients had been observed for the development of immediate postprocedural
ischaemic events. Working hours of our laboratory were divided into 2-hourly
intervals in order to define the ending time of procedure. Analysis of acute
complications was carried out according to the ending time of procedure.
Results There was no difference with regard to clinical
presentation, but patients who had complications had higher blood cholesterol
level (P < 0.05). Patients with stent implantation
had more adverse events than the PTCA group, but this difference did not reach
the statistical significance (P = 0.07). The time
interval between 10:30 a.m.-12:30 p.m. was found to be an independent risk
factor for the negative outcomes (P = 0.043,
Relative Risk 4838).
Conclusion The results of our study have demonstrated that
postprocedural complications after angioplasty is related to the procedure time
These patients may be observed more closely for the development of immediate
postprocedural ischaemic events.
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