Orally disintegrating dosage forms in epilepsy management: Formulation strategies,evaluation,and clinical potential

Abstract

Epilepsy is a neurological disorder that requires long-term pharmacological treatment. Conventional oral antiepileptic dosage forms often present limitations such as swallowing difficulties, delayed onset of action, and reduced patient compliance. Orally disintegrating dosage forms (ODDFs) have emerged as a suitable alternative to overcome these challenges. These formulations rapidly disintegrate in the oral cavity without the need for water, making them particularly beneficial for pediatric, geriatric, and epileptic patients. This article reviews the concept and significance of ODDFs in epilepsy management. It focuses on formulation considerations, selection of excipients, methods of preparation, and evaluation parameters associated with ODDFs. The advantages of ODDFs in terms of ease of administration, patient acceptability, and improved therapeutic performance are also discussed. Furthermore, it highlights recent case studies involving antiepileptic drugs, demonstrating the therapeutic potential of ODDFs. The article emphasizes the potential of orally disintegrating dosage forms as an effective drug delivery approach to enhance treatment outcomes and patient compliance in epilepsy therapy.