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References
1.
Hernán
MA
. The hazards of hazard ratios . Epidemiology 2010 ; 21 : 13 –15 .
2.
Aalen
OO
Cook
RJ
Røysland
K
. Does Cox analysis of a randomized survival study yield a causal treatment effect? Lifetime Data Anal 2015 ; 21 (4 ): 579 –593 .
3.
Martinussen
T
Vansteelandt
S
Andersen
PK
. Subtleties in the interpretation of hazard contrasts . Lifetime Data Anal 2020 ; 26 (4 ): 833 –855 .
4.
Martinussen
G
. Causality and the Cox regression model . Annu Rev Stat Appl 2022 ; 9 : 249 –259 .
5.
Stensrud
MJ
Aalen
JM
Aalen
OO
, et al . Limitations of hazard ratios in clinical trials . Eur Heart J 2019 ; 40 : 1378 –1383 .
6.
Frangakis
CE
Rubin
DB
. Principal stratification in causal inference . Biometrics 2002 ; 58 (1 ): 21 –29 .
7.
Aalen
OO
Hjort
NL
. Frailty models that yield proportional hazards . Stat Probabil Lett 2002 ; 58 (4 ): 335 –342 .
8.
Fay
MP
Li
F
. Causal interpretation of the hazard ratio in randomized clinical trials . Clin Trials 2024 ; 21 (5 ): 638 –639 .
9.
Lipkovich
I
Ratitch
B
Qu
Y
, et al . Using principal stratification in analysis of clinical trials . Stat Med 2022 ; 41 (19 ): 3837 –3877 .
