ZarinDATseTWilliamsRJ. The ClinicalTrials.gov results database—update and key issues. N Engl J Med2011; 364: 852–860.
2.
TricociPAllenJMKramerJM. Scientific evidence underlying the ACC/AHA clinical practice guidelines. JAMA2009; 301: 831–841.
3.
RossJSTseTZarinDA. Publication of NIH funded trials registered in ClinicalTrials.gov: cross sectional analysis. BMJ2012; 344: d7292.
4.
CaliffRMZarinDAKramerJM. Characteristics of clinical trials registered in ClinicalTrials.gov, 2007–2010. JAMA2012; 307: 1838–1847.
5.
GordonDTaddei-PetersWMascetteA. Publication of trials funded by the National Heart, Lung, and Blood Institute. N Engl J Med2013; 369: 1926–1934.
6.
PetoRBaigentC. Trials: the next 50 years. Large scale randomised evidence of moderate benefits. BMJ1998; 317: 1170–1171.
7.
Institute of Medicine. The learning healthcare system: workshop summary. Washington, DC: National Academies Press, 2007.
8.
SugarmanJCaliffRM. Ethics and regulatory complexities for pragmatic clinical trials. JAMA2014; 311: 2381–2382.
9.
FadenRRBeauchampTLKassNE. Informed consent, comparative effectiveness, and learning health care. N Engl J Med2014; 370: 766–768.
10.
FadenRRKassNEGoodmanSN. An ethics framework for a learning health care system: a departure from traditional research ethics and clinical ethics. Hastings Cent Rep2013; 43: S16–S27.