Between 1986 and 1990 50 patients with ovarian cancer were submitted to a procedure which we called REGAJ - resection guided by antibodies. Using the radiolabeled murine monoclonal antibody OC 125, microscopic ovarian tumors producing CA 125 were detected during second-look surgery by a hand-held probe. Retrospective analysis after 10 years revealed that this procedure resulted in the cure of 4 of 11 patients, who would otherwise have been considered tumor free during second-look surgery and not further treated. Previous problems associated with the method can now be solved so that the clinical value of the procedure should be reconsidered.
JägerW., FeistelH., PaterokE.M.Resection guided by antibodies (REGAJ): a diagnostic procedure during second-look operation in ovarian cancer patients.Br J Cancer1990; 62: 18–20.
2.
CohenA.M., MartinE.W., LaveryI.Radioimmunoguided surgery using iodine 125 B72.3 in patients with colorectal cancer.Arch Surg1991; 126: 349–52.
3.
Uttenreuther-FischerM.M., FeistelH., WolfF., JägerW.Distribution of radiolabelled anti-CA 125 monoclonal antibody OC 125-F(ab')2-fragment following resection guided by antibodies (REGAJ) in ovarian cancer patients.J Clin Lab Anal1997; 11: 94–103.
