Two specific monoclonal antibodies for breast tissue (DF3 and MCAb-12) and the corresponding tumor markers CA15-3 and MCA in serum have been evaluated in 50 patients with breast cancer and in 15 controls. The expression of these antigens in tissue was poorly correlated with the common prognostic parameters. Their presence in serum was associated with an altered distribution of the antigens in the cell. The expression of these antigens in tissue enables us to select patients for serological follow-up and to evaluate tumor differentiation from a functional point of view.
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2.
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BoccardoF., BombardieriE., ZanardiS., ValentiG., ZanaboniF., ValtolinaM., SeregniE., CrippaF.Preliminary study on serum levels of mucinous-like cancer antigen (MCA) in patients with breast disease: comparison with CEA.Int J Biol Markers1991; 6(1): 12–20.
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7.
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HilkensJ., kroezenV., BronfrerJ.M.G., BruningP.F., HilghersJ., Van EijkerenA.A sandwich-radioimmunoessay for a new antigen (MAM-6) present in the sera of patients with metastatized carcinomas. In: PeetersH, ed. Protides of the biological fluids, 32nd edition.Oxford: Pergamon Press, 1984; 6551–653.
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ZenklusenH.R., Von OverbeckJ., StahliC., GudatF., RolinkH., HeitzP.U.The immuno-histochemical reactivity of a monoclonal antibody (MAb b-12) against breast carcinomas and other normal and neoplastic human tissues.Virch Arch (A)1988; 413: 3–10.
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MartinazziM., CrivelliF., GrassiC., ZampattiC.Immunohistochemical distribution of mucinous-like carcinoma associated antigen (MCA) in breast and non-breast cancer: comparison with other biological parameters.Int J Biol Markers1990; 3: 138–44.
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OhtaniH., NaguraH., OhuchiN.Immunoelectron microscopic localization of DF 3 cancer associated antigen in human breast cancer.Path Res Pract1991; 187: 1014–9.
12.
RasmussenB.B., HilkensJ.H., HilgersJ., NielsenH.H., ThorpeS.M., RoseC.Monoclonal antibodies applied to primary human breast carcinoma; relationship to menopausal status, lymph node status and steroid hormone receptor content.Breast Cancer Research and Treatment1982; 2: 401–5.
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BombardieriE., GiovM., MioneR., DittadiR., BruscagninG., BuraggiG.A mucinous like carcinoma associated antigen (MCA) in the tissue and blood of patients with primary breast cancer.Cancer1989; 3: 490–5.
14.
OhuchiN., PageD.L., MerinoM.J.Expression of tumor-associated antigen (DF3) in atypical hyperplasias and in situ carcinomas of the human breast.J Natl Cancer Inst1987; 79: 109–17.
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GionM., MioneR., DittadiR., FasanS., PalliniA., BuscagninG.Evaluation of CA 15.3 serum levels in breast cancer patiensJ Nucl Med All Sci1986; 30: 1–7.
16.
Pons-AnicetD.M.F., KrebsB.P., MiraR., NamerM.Values of CA 15-3 in the follow-up of breast cancer patients.Br J Cancer1987; 55: 567–9.
17.
ByrneJ., HorganP.G., EnglandS., CallaghanJ., GivenH.F.A preliminary report on the usefulness of monoclonal antibodies to CA 15-3 and MCA in the detection of micrometastases in axillary lymph nodes draining primary breast carcinoma.Eur J Cancer1992; 28(2-3): 658–60.
18.
Saccani JottiG., GrassiC., FontanesiM., BecchiG., TardiniA.Demonstration of mucinous-like carcinoma-associated antigen in bone marrow and lymph node biopsies from patients with breast carcinoma.Int J Biol Markers1991; 3: 167–72.
