The high specificity and sensitivity of testicular tumor markers make them particularly useful in the management of these neoplasms. Basal value represents an independent prognostic variable, influencing the choice of therapy. An increase in marker level before chemotherapy could also acquire a powerful prognostic significance. The decay curve pattern is indicative of the radicality of surgery. Also during chemotherapy the behavior of markers conditions further therapeutic strategies.
BagshawK.D., BegentR.H.J.Staging, markers and prognostic factors.Clin in Oncol1983; 2: 159–81.
2.
FossaA., FossaS.D.Serum lactate dehydrogenase and human choriogonadotrophin in seminoma.Br J Urol1989; 63: 408–15.
3.
LangeP.H., WinfieldH.N.Biological markers in urologic cancer.Cancer1987; 60: 464–72.
4.
BombardieriE., PizzocaroG., SeregniE., CastellaniM.R., CozziA., BuraggiG.L.I marcatori circolanti dei tumori germinali del testicolo. In: VeronesiU., PizzocaroG., PisaniE., SantoroA., eds. I tumori genito-urinari.Milano: Casa Editrice Ambrosiana, 1989; 263–74.
5.
VogelzangN.J.Prognostic factors in metastatic testicular cancer.Int J Androl1987; 10: 225–37.
6.
SalvioniR., ZanoniF., MilaniA., PivaL., AguzziL., PizzocaroG.Classificazione in stadi dei tumori germinali del testicolo. In: VeronesiU., PizzocaroG., PisaniE., SantoroA., eds. I tumori genito-urinari.Milano: Casa Editrice Ambrosiana, 1989; 283–6.
7.
PriceP., HoganS.G., HorwichA.The growth rate of metastatic non-seminomatus germ cell testicular tumours measured by marker production doubling time - I. Theoretical basis and practical application.Eur J Cancer1990; 26: 450–3.
8.
PriceP., HoganS., HorwichA.The growth rate of metastatic non-seminomatous germ cell testicular tumours measured by marker production doubling time - II. Prognostic significance in patients treated by chemotherapy.Eur J Cancer1990; 26: 453–7.
9.
HorwichA., PeckhamM.J.Serum tumor marker regression ratio following chemotherapy for malignant teratoma.Eur J Cancer Clin Oncol1984; 20: 1463–70.
10.
PicozziV.J.Jr., FreihaF.S., HanniganJ.F.Jr., TortiF.M.Prognostic significance of a decline in serum human chorionic gonadotropin levels after initial chemotherapy for advanced germ-cell.Ann Int Med1984; 100: 183–6.
11.
TonerG.C., GellerN.L., TanC., BoslG.J.Serum tumor marker half-life during chemotherapy (CT) allows early prediction of complete response (CR) and survival in non-seminomatous germ cell tumors (NSGCT).Proc Am Soc Clin Oncol ASCO1990; 9: 133 (abs. 514).
12.
TonerG.C., GellerN.L., TanC., NisselbaumJ., BoslG.J.Serum tumor marker half-life during chemotherapy allows early prediction of complete response and survival in nonseminomatous germ cell tumors.Cancer Res1990; 50: 5904–10.
13.
HoskinP., DillyS., EastonD., HorwichA., HendryW., PeckhamM.J.Prognostic factors in stage I non-seminomatous germ-cell testicular tumors managed by orchiectomy and surveillance: implications for adjuvant chemotherapy.J Clin Oncol1986; 4: 1031–6.
14.
WilliamsS.D., StableinD.N., EinhornL.H.Immediate adjuvant chemotherapy versus observation with treatment at relapse in pathological stage II testicular cancer.N Engl J Med1987; 317: 1433–8.
15.
VugrinD., FriedmanA., WhitmoreW.F.Correlation of serum tumor markers in advanced germ cell tumors with responses to chemotherapy and surgery.Cancer1984; 53: 1440–5.
