MCA (Mucinous Carcinoma-Associated Antigen) levels of 176 breast carcinoma patients were tested postoperatively by serial determination. One hundred forty-one patients had nonprogressive disease (PD–) while 35 were in the progressive phase (PD +); in the latter the diagnosis was confirmed by means of current diagnostic procedures.
One hundred seventeen of the 141 PD– patients showed MCA levels below cutoff whereas 27 of the 35 PD + cases showed high values. The difference in the incidence of elevated MCA levels between PD–and PD + groups was statistically significant (p < 0.05). The overall diagnostic efficacy of MCA assays showed 77% sensitivity and 82% specificity.
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