Restricted accessResearch articleFirst published online 1988-4
Short-term Effects of i.v. Injected Murine 99M Tc-F(ab’) 2 Fragments of an Anti-Melanoma Antibody (HMW-MAA 225.28 S) on Haemato-Immunological Parameters in Patients with Melanoma
To evaluate alterations induced by injectedmurine radiolabelled F(ab’)2 fragments of the anti HMW-MAA MoAb 225.28S on the principal haemato-immunological parameters, 32 patients with advanced malignant melanoma were studied. No statistically significant change was found after MoAb administration, but monocytes (3h after injection) and granular eosinophils (24 h after) were reduced and circulating immune complexes increased (3 h after). No toxic effect or adverse reaction was observed.
Therefore, the controlled administration of purified MoAb fragments for diagnostic purposes seems to involve only a very low risk of immediate adverse reactions
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