Short-term Effects of i.v. Injected Murine 99M Tc-F(ab’) 2 Fragments of an Anti-Melanoma Antibody (HMW-MAA 225.28 S) on Haemato-Immunological Parameters in Patients with Melanoma
Restricted accessResearch articleFirst published online April, 1988
Short-term Effects of i.v. Injected Murine 99M Tc-F(ab’) 2 Fragments of an Anti-Melanoma Antibody (HMW-MAA 225.28 S) on Haemato-Immunological Parameters in Patients with Melanoma
To evaluate alterations induced by injectedmurine radiolabelled F(ab’)2 fragments of the anti HMW-MAA MoAb 225.28S on the principal haemato-immunological parameters, 32 patients with advanced malignant melanoma were studied. No statistically significant change was found after MoAb administration, but monocytes (3h after injection) and granular eosinophils (24 h after) were reduced and circulating immune complexes increased (3 h after). No toxic effect or adverse reaction was observed.
Therefore, the controlled administration of purified MoAb fragments for diagnostic purposes seems to involve only a very low risk of immediate adverse reactions
WilsonB.S., GiacominiP., ImaiK.. Human melanoma-associated antigens identified with monoclonal antibodies.Ricerca Clin Lab1982; 12: 517–38.
2.
FerroneS., GiacominiP., NataliP.G.. A human high molecular weight-melanoma associated antigen (HMW-MAA) defined by monoclonal antibodies: a useful marker to radioimage tumor lesion in patients with melanoma.Proc 1st Int Symp Neutron Capture Therapy, MIT, Boston, Oct 12-14, 1983; 174–83.
3.
BuraggiG.L., CallegaroL., TurrinA.. Immunoscintigraphy with 123I, 99mTc and 111 In-labelled F(ab’)2 fragments of monoclonal antibodies to a human high molecular weight-melanoma associated antigen.J Nucl Med All Sci1984; 28: 283–95.
4.
BuraggiG.L., CallegaroL., MarianiG.. Imaging with 131I-labelled monoclonal antibodies to a High-Molecular-Weight Melanoma-Associated Antigen in patients with melanoma: efficacy of whole immunoglobulin and its F(ab’)2 fragments.Cancer Res1985; 45: 3378–87.
5.
SiccardiA.G., BuraggiG.L., CallegaroL.. Multicenter study of immunoscintigraphy with radiolabelled monoclonal antibodies in patients with melanoma.Cancer Res1986; 46: 4817–22.
6.
MansiL., VenutaS., FerroneS.. In vivo evaluation of an anti-melanoma antibody, F(ab’)2, labelled with Tc-99m. In: GiraldoG., eds. From oncogenes to tumor antigens.Amsterdam: Elsevier Sci Pub, 1985; 155–65.
7.
SalvatoreM., MansiL., Del VecchioS.. Valutazione delle possibilità diagnostiche della Immunos-cintigrafia nel melanoma.It Curr Radiol1985; 4: 201–5.
8.
StehlinJ.S.Jr., ClarkR.L., VickersW.E., MongesA.Perfusion for malignant melanoma of the extremities.Am J Surg1963; 105: 607–14.
9.
CastelloG., MelilloG., D'AlessioV.. Relationship between immunodeficiency conditions and AIDS-AIDS-associated retrovirus (ARV) infection in homosexual men and i.v. drug abusers in the Campania Region.Haematologica1986; 71: 453–7.
10.
CastelloG.Dalla Mora L, Nitsch F, et al. Immuno-complessi circolanti nel cancro della mammella: valutazione mediante tre metodiche differenti.Ligand Quarterly1983; 2: 65–8.
