The heritability of primary Raynaud's phenomenon has been reported in previous works. In this paper we describe the simultaneous onset of Raynaud's phenomenon, rapidly evolved in acrocyanosis and diagnosed as secondary Raynaud's phenomenon, observed in monozygotic twins. This case supports the role of genetic factors in the pathogenesis of such disorder. Moreover, the singular synchronism of its appearance is discussed.
RaynaudM. Local asphyxia and symmetrical gangrene of the extremities 1862. New researches on the nature and treatment of local asphyxia of the extremities 1874. Translated by BarlowLondon: New Sydenham Society, 1888.
LeRoyECMedsgerTAJr. Raynaud's phenomenon: A proposal for classification. Clin Exp Rheumatol1992; 10(5):485–8.
6.
HerrickAL. Pathogenesis of Raynaud's phenomenon. Rheumatology2005; 44:587–96.
7.
BakstRMerolaJFFranksAGJrSanchezM. Raynaud's phenomenon: Pathogenesis and management. J Am Acad Dermatol2008; 59(4):633–53.
8.
FreedmanRRMayesMD. Familial aggregation of primary Raynaud's disease. Arthritis Rheum1996; 39:1189–91.
9.
OskayTOlmezU. Primary Raynaud's phenomenon in monozygotic twins. Ann Rheum Dis2004; 63:219.
10.
SusolEMacGregorAJBarrettJHWilsonHBlackCWelshKSilmanAOilierBWorthingtonJ. A two stage, genome-wide screen for susceptibility loci in primary Raynaud's phenomenon. Arthritis Rheum2000; 39(7): 1641–6.
11.
CherkasLFWilliamsLKCarterLHowellKBlackCMSpectorTDMacgregorAJ. Heritability of Raynaud's phenomenon and vascular responsiveness to cold: A study of adult female twins. Arthritis Rheum2007; 57(3):524–8.
12.
AndersHJSiglTSchattenkirchnerM. Differentiation between primary and secondary Raynaud's phenomenon: A prospective study comparing nailfold capillaroscopy using an ophtalmoscope or stereomicroscope. Ann Rheum Dis2001; 60:407–9.
13.
Spencer-GreenG. Outcomes in primary Raynaud phenomenon: A meta-analysis of the frequency, rates, and predictors of transition to secondary disease. Arch Intern Med1998; 158:595–600.
14.
NumanoFIsohisaIKishiUAritaMMaezawaH. Takayasu's disease in twin sisters. Possible genetic factors. Circulation1978; 58(1): 173–7.
