In this study we describe some biological effects of IL-34, a newly discovered cytokine. We show that Il-34 stimulates monocyte cell viability and directly modulates the number and function of monocytes and regulates myeloid cell growth and differentiation. Moreover, since IL-34 in mice is involved in osteoporosis, an antagonist of this cytokine could be beneficial for the treatment of this disease.
LinHLeeEHestirKLeo. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science2008; 3207:07–811.
2.
CovaledaLFullerFJPayneSL. EIAV S2 enhances pro-inflammatory cytokine and chemokine response in infected macrophages. Virology2009; 397:217–23.
3.
OppenheimJJZacharieCOCMukaidaNMatsushimaK. Properties of the novel proinflammatory supergene “Intercrine” cytokine family. Annu Rev Immunol1991; 9:617–23.
4.
YinYYanYJiangXMaiJChenNCWangHYangX-F. Inflammasomes are differentially expressed in cardiovascular and other tissues. Int J Immunopathol Pharmacol2009; 22:311–22.
5.
FotioALOllerosMLVesinDT. In vitro inhibition of lipopolysaccharide and mycobacterium bovis bacillus Calmette Guérin-induced inflammatory cytokines and in vivo protection from D-galactosamine/LPS -mediated liver injury by the medicinal plant Sclerocarya birrea. Int J Immunopathol Pharmacol2010; 3:61–72.
6.
GibbsBF. Differential modulation of IgE-dependent activation of human basophils by ambroxol and related secretolytic analogues. Int J Immunopathol Pharmacol2009; 22:919–27.
7.
MengXTancharoenSKawaharaKINawaYTaniguchiSHashiguchiTMaruyamaI. 1,5-Anhydroglucitol attenuates cytokine release and protects mice with type 2 diabetes from inflammatory reactions. Int J Immunopathol Pharmacol2010; 23:105–19.
8.
ContiPPangXBoucherWLetourneauRRealeMBarbacaneRCThibaultJTheoharidesTC. Impact of Rantes and MCP-1 chemokines on in vivo basophilic cell recruitment in rat skin injection model and their role in modifying the protein and mRNA levels for histidine decarboxylase. Blood1997; 89:4120–7.
CaldarolaGDe SimoneCCarboneATulliAAmerioPFelicianiC. TNFα and its receptors in psoriatic skin, before and after treatment with Etanercept. Int J Immunopathol Pharmacol2009; 22:961–6.
11.
CastellaniMLVecchietJSaliniV. Stimulation of CCL2 (MCP-1) and CCL2 mRNA by substance P in LAD2 human mast cellsTranl Res2009; 154:27–33.
12.
Di LorenzoGMansuetoPPacorML. Clinical importance of eosinophil count in nasal fluid in patients with allergic and non-allergic rhinitis. Int J Immunopathol Pharmacol2009; 22:1077–87.
13.
MinelliMSchiavinoDMuscaF. Oral hyposensitization to nickel induces clinical improvement and a decrease in TH1 and TH2 cytokines in patients with systemic nickel allergy syndrome. Int J Immunopathol Pharmacol2010; 23:193–201.
14.
Del PreteGSantiLAndrianaivoarimananaVAmedeiADomarleOD'EliosMMArntzenCJRahalisonLMasonHS. Plant-derived recombinant F1, V, and F1-V fusion antigens of Yersinia pestis activate human cells of the innate and adaptive immune system. Int J Immunopathol Pharmacol2009; 22:133–43.
15.
ChibaYSatoSMisawaM. GGTI-2133, an inhibitor of geranylgeranyltransferase, inhibits infiltration of inflammatory cells into airways in mouse experimental asthma. Int J Immunopathol Pharmacol2009; 22:929–35.
16.
Di PaolaRCrisafulliCMazzonEGenoveseTPaternitiIBramantiPCuzzocreaS. Effect of PD98059, a selective MAPK3/MAPK1 inhibitor, on acute lung injury in mice. Int J Immunopathol Pharmacol2009; 22:937–50.
17.
IndinnimeoLBertuolaFCutreraR. Clinical evaluation and treatment of acute asthma exacerbations in children. Int J Immunopathol Pharmacol2009; 22:867–78.
18.
De Moreno De LeblancAChavesSPerdigónG. Effect of yoghurt on the cytokine profile using a murine model of intestinal inflammationEur J Inflamm2009; 7:97–110.
19.
CastellaniMLFelacoPPandolfiF. Inflammatory compounds: Neuropeptide substance P and cytokines. Eur J Inflamm2009; 7:63–70.
20.
Baud'huinMRenaultRCharrierCRietAMoreauABrionRGouinFDuplombLHeymannD. Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis. J Pathol2010; 221:77–86.
21.
DroinNSolaryE. Editorial: CSF1R, CSF-1, and IL-34, a “menage a trois” conserved across vertebrates. J Leukoc Biol2010; 87:745–7.
22.
CiprandiGFenoglioDDe AmiciMMarsegliaGMurdacaGDi GioacchinoM. Serum IL-1 after one course of sublingual immunotherapy in allergic rhinitis to birch. Eur J Inflamm2009; 7:49–54.
23.
CiprandiGCadarioGDi GioacchinoM. Intermittent and persistent allergic rhinitis and association with asthma in children. Eur J Inflamm2008; 6:123–8.
24.
CastellaniMLKempurajDFrydasSTheoharidesTCSimeonidouIContiPVecchietJ. Inhibitory effect of quercetin on tryptase and MCP-1 chemokine release, and histidine decarboxylase mRNA transcription by human mast cell-1 cell line. Neuroimmunomodulation2006; 13:179–86.
25.
ArdizzoneSCassinottiATrabattoniD. Immunomodulatory effects of 1,25-dihydroxyvitamin D3 on TH1/TH2 cytokines in inflammatory bowel disease: An in vitro study. Int J Immunopathol Pharmacol2009; 22:63–71.
26.
LeeHHanARKimYChoiSHKoELeeNYJeongJHKimSHBaeH. A new compound, 1H,8H-pyrano[3,4-c]pyran-1,8-dione, suppresses airway epithelial cell inflammatory responses in a murine model of asthma. Int J Immunopathol Pharmacol2009; 22:591–603.
27.
Di BonitoPGrassoFManginoG. Immunomodulatory activity of a plant extract containing human papillomavirus 16-E7 protein in human monocyte-derived dendritic cells. Int J Immunopathol Pharmacol2009; 22:967–78.
CastellaniMLCiampoliCFelacoM. Neuropeptide substance P induces mRNA expression and secretion of CXCL8 chemokine, and HDC in human umbilical cord blood mast cells. Clin Invest Med2008; 31:E362–72.
30.
FrydasSPapaioannouNRealeMBarbacaneRCContiP. MCP-1 and MIP-2 response in Trichinella spiralis-infected mice treated with 4-deoxypyridoxinc (4-DPD). Immunol Lett2002; 83:31–7.
31.
ContiPKempurajDKandereK. Interleukin-16 network in inflammation and allergy. Allergy Asthma Proc2002; 23:103–8.
32.
MalerbaMMennuniLPiepoliTCaselliGMakovecFRovatiLCD'amatoMFerrariF. Andolast acts at different cellular levels to inhibit immunoglobulin E synthesis. Int J Immunopathol Pharmacol2009; 22:85–94.
33.
CastellaniMLContiPFelacoMVecchietJCiampoliCCerulliGBoscoloPTheoharidesTC. Substance P upregulates LTB4 in rat adherent macrophages from granuloma induced by KMnO4. Neurotox Res2009; 15:49–56.
34.
FiettaAMMorosiniMPassadoreICascinaADraghiPDoreRRossiSPozziEMeloniF. Systemic inflammatory response and downmodulation of peripheral CD25+Foxp3+ T-regulatory cells in patients undergoing radiofrequency thermal ablation for lung cancer. Hum Immunol2009; 70:477–86.
35.
LipariLMauroATortoriciSBurruanoFLeoneASpatolaGFGerbinoABuscemiMTetèS. Immunohistochemical and transcriptional expression of the matrix metalloproteinases MMP-2 and MMP-9 in normal and pathological human oral mucosa. J Biol Regul Homeost Agents2009; 23:259–67.
36.
D'AgostoGTrentoENosottiL. CD81 expression on CD19+ peripheral blood lymphocytes is associated with chronic HCV disease and increased risk for HCV infection: A putative role for inflammatory cytokines. J Biol Regul Homeost Agents2009; 23:155–64.
37.
AntonucciIPantaloneADe AmicisDD'OnofrioSStuppiaLPalkaGSaliniV. Human amniotic fluid stem cells culture onto titanium screws: A new perspective for bone engineering. J Biol Regul Homeost Agents2009; 23:277–9.
38.
CabrelleAMaschioNCarraroS. Apoptotic effect of cyclosporin A and dexamethasone in malignant cells of patients with B-chronic lymphocytic leukaemia. J Biol Regul Homeost Agents2009; 23:239–250.
39.
NishimuraYMaedaMKumagaiNHayashiHMiuraYOtsukiT. Decrease in phosphorylation of ERK following decreased expression of NK cell activating receptors in human NK cell line exposed to asbestos. Int J Immunopathol Pharmacol2009; 22:879–88.
40.
Di PaolaRCrisafulliCMazzonEGenoveseTPaternitiIBramantiPCuzzocreaS. Effect of PD98059, a selective MAPK3/MAPK1 inhibitor, on acute lung injury in mice. Int J Immunopathol Pharmacol2009; 22:937–50.
41.
ZampettiAMastrofrancescoAFloriEMarescaVPicardoMAmerioPFelicianiC. Proinflammatory cytokine production in HaCaT cells treated by eosin: Implications for the topical treatment of psoriasis. Int J Immunopathol Pharmacol2009; 22:1067–75.
42.
D'AgostoGTrentoENosottiL. CD81 expression on CD19+ peripheral blood lymphocytes is associated with chronic HCV disease and increased risk for HCV infection: A putative role for inflammatory cytokines. J Biol Regul Homeost Agents2009; 23:155–64.
