Tighter regulations needed for over-the-counter codeine in Canada

Government of Canada. Narcotic Control Regulations (C.R.C., c. 1041). 2014. Available: http://laws-lois.justice.gc.ca/eng/regulations/C.R.C.,_c._1041 (accessed Apr. 11, 2014).

Sproule B Busto U Somer G . Characteristics of dependent and nondependent regular users of codeine. J Clin Psychopharmacol 1999;19:367-72.

Brands B Blake J Sproule B . Prescription opioid abuse in patients presenting for methadone maintenance treatment. Drug Alcohol Depend 2004;73:199-207.

Sproule B Brands B Li S . Changing patterns in opioid addiction. Can Fam Physician 2009;55:68-69.e5.

Yang J Zlomislic D. Star investigation: Canada’s invisible codeine problem. The Toronto Star. Jan. 17, 2015. Available: www.thestar.com.

Orriols L Gaillard J Lapeyre-Mestre M . Evaluation of abuse and dependence on drugs used for self-medication. Drug Saf 2009;32(10):859-73.

Frei M Nielsen S Dobbin M . Serious morbidity associated with misuse of over-the-counter codeine-ibuprofen analgesics: a series of 27 cases. Med J Aust 2010;193(5):294-6.

McAvoy B Dobbin M Tobin C. Over-the-counter codeine analgesic misuse and harm: characteristics of cases in Australia and New Zealand. N Z Med J 2011;124(1346):29-34.

Tobin C Dobbin M McAvoy B. Regulatory responses to over-the-counter codeine analgesic misuse in Australia, New Zealand and the United Kingdom. Aust N Z J Public Health 2013;37(5):483-8.

Robinson G Robinson S McCarthy P . Misuse of over-the-counter codeine-containing analgesics: dependence and other adverse effects. N Z Med J 2010;123(1317):59-65.

Roxburgh A Hall W Burns L . Trends and characteristics of accidental and intentional codeine overdose deaths in Australia. Med J Aust 2015;203(7):299.

Gomes T Juurlink D Yao Z . Impact of legislation and a prescription monitoring program on the prevalence of potentially inappropriate prescriptions for monitored drugs in Ontario: a time series analysis. CMAJ Open 2014;2(4):E256-61.

Clark T Eadie J Knue P . Prescription drug monitoring programs: an assessment of the evidence for best practices. Waltham (MA): Heller School for Social Policy and Management, Brandeis University; 2012.

Sproule B. Prescription monitoring programs in Canada: best practice and program review. Ottawa (ON): Canadian Centre on Substance Abuse; 2015.

Alberta College of Pharmacists. ACP News. Jul/Aug 2015. Available: https://pharmacists.ab.ca/newsletter (accessed Jan. 4, 2016).

Saskatchewan College of Pharmacists. Policy statement: control over the sales of exempted codeine products. Apr. 6 2010. Available: www.saskpharm.ca/site/manual?nav=03 (accessed Oct. 2, 2015).

Governement of New Brunswick. Drug information system and prescription monitoring program. Available: www2.gnb.ca (accessed May 30, 2016).

Prince Edward Island Pharmacy Board. The Island Capsule Newsletter. Feb. 2013. Available: http://www.pepharmacists.ca/document/932/February%202013%20(1).pdf (accessed Jan. 4, 2016).

Nova Scotia College of Pharmacists. Position statement: sale of exempted codeine preparations. Sep. 2015. Available: http://www.nspharmacists.ca/wp-content/uploads/2015/11/Sale-of-Exempted-Codeine_Position_Approved-Sept2015.pdf

Health Canada, Health Products and Food Branch. Guidance document: determining prescription status for human and veterinary drugs. 2013. Available: www.hc-sc.gc.ca/dhp-mps/prodpharma/pdl-ord/index-eng.php (accessed Jun. 22, 2015).

Boak A Hamilton H Adlaf E . Drug use among Ontario students, 1977-2013: detailed OSDUHS findings (CAMH Research Document Series No. 36). Toronto (ON): Centre for Addiction and Mental Health; 2013.

De Craen A Di Giulio G Lampe-Schoenmaeckers A . Analgesic efficacy and safety of paracetamol-codeine combinations versus paracetamol alone: a systematic review. BMJ 1996;313(7053):321-5.

Smith L Moore R McQuay H . Using evidence from different sources: an example using paracetamol 1000 mg plus codeine 60 mg. BMC Med Res Methodol 2001;1:1.

Moore R Derry S Mcquay H . Single dose oral analgesics for acute postoperative pain in adults. Cochrane Database Syst Rev 2011;(9):CD008659.

Mitchell A van Zanten S Inglis K . A randomized controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine after outpatient general surgery. J Am Coll Surg 2008;206(3): 472-9.

Daniels S Goulder M Aspley S . A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen/paracetamol for postoperative dental pain. Pain 2011;152(3):632-42.

Nauta M Landsmeer M Koren G. Codeine-acetaminophen versus nonsteroidal anti-inflammatory drugs in the treatment of post-abdominal surgery pain: a systematic review of randomized trials. Am J Surg 2009;198(2):256-61.

Smith S Schroeder K Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev 2012;(8):CD001831.

Manitoba College of Pharmacists. Practice direction: exempted codeine preparations. 2015. Available: http://mpha.in1touch.org/site/legislation?nav=practice (accessed Dec. 20, 2015).