Black Cohosh Practical Management of Adverse Effects and Drug Interactions

Natural Standard Monograph. Black cohosh. Natural Standard 2006. Available: www.naturalstandard.com (accessed May 2006)

Dog T Low Powell KL Weisman SM . Critical evaluation of the safety of Cimicifuga racemosa in menopause symptom relief. Menopause 2003; 10:299–313

Belisle S Blake J Basson R . Canadian consensus conference on menopause, 2006 update. J Obstet Gynaecol Can 2006 Feb; 28 (2 Suppl 1): S7–S94

North American Menopause Society. Treatment of menopause-associated vasomotor symptoms: position statement of The North American Menopause Society. Menopause 2004; 11:11–33

Mills SY Jacoby RK Chacksfield M Willoughby M . Effect of a proprietary herbal medicine on the relief of chronic arthritic pain: a double-blind study. Br J Rheumatol 1996; 35:874–8

Huntley AL Ernst E . A systematic review of safety of black cohosh. Menopause 2003; 10:58–64

Dog T Low . Menopause: a review of botanical dietary supplements. Am J Med 2005; 118:98S–108S

Whiting PW Clouston A Kerlin P . Med J Aust 2002; 177:440–3

Levitsky J Alli TA Wiscarver J Sorrell MF . Fulminant liver failure associated with the use of black cohosh. Dig Dis Sci 2005; 50:538–9

Lontos S Jones RM Angus PW Gow PJ . Acute liver failure associated with the use of herbal preparations containing black cohosh. Med J Aust 2003; 179:390–1

Shuster J . Heparin and thrombocytopenia. Black cohosh root? Chasteberry tree? Seizures! Hosp Pharm 1996; 31:1553–4

Liu J Burdette JE Xu H . Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001; 49:2472–9

Borrelli F Izzo AA Ernst E . Pharmacological effects of Cimicifuga racemosa. Life Sci 2003; 73:1215–29

Einer-Jensen N Zhao J Andersen KP Kristoffersen K . Cimicifuga and Melbrosia lack oestrogenic effects in mice and rats. Maturitas 1996; 25:149–53

Jacobson JS Troxel AB Evans J . Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol 2001; 19:2739–45

Munoz G Hernandez Pluchino S . Cimicifuga racemosa for the treatment of hot flushes in women surviving breast cancer. Maturitas 2003; 44 Suppl 1: S59–65

Mahady GB Fabricant D Chadwick LR Dietz B . Black cohosh: an alternative therapy for menopause? Nutr Clin Care 2002; 5:283–9

Boon H Smith M . The complete natural medicine guide to the 50 most common medicinal herbs. Hilderley B , editor. 2nd edition. Canada: Robert Rose Inc.; 2004

Gurley B Hubbard MA Williams DK . Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin. J Clin Pharmacol 2006; 46:201–13