GargUC, HassidA,. Nitric oxide-generating vasodilators and 8-bromocyclic guanosine monophosphate inhibit mitrogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest1989;83:1774–7.
6.
CohenRA, ZitnayKM, HaudenschildCC, CunninghamLD. Loss of selective endothelial cell vasoactive functions in pig coronary arteries caused by hypercholesterolemia. Circ Res1988;63:903–10.
7.
JacobsM, PlaneF, BruckdorferKR. Native and oxidized low-density lipoproteins have different inhibitory effects on endothelium-derived relaxing factor in the rabbit aorta. Br J Pharmacol1990;100:21–6.
8.
KugiyamaK, KernsSA, MorrisettJD, RobertsR, HenryPD. Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins. Nature1990;344:160–2.
DrexlerH, ZeiherAM, MeinzerK, JustH. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet1991;338(8782-8783):1546–50.
12.
BögerRH, Bode-BögerSM, ThieleW,. Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlusive disease. Circulation1997;95:2068–74.
13.
Bode-BögerSM, BögerRH, AlfkeH, HeinzelD, TsikasD, CreutzigA,. L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized controlled study. Circulation1996;93:85–90.
14.
LermanA, BurnettJCJr, HiganoST, McKinleyLJ, HolmesDRJr. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation1998;97(21):2123–8.
15.
PollockJS, FörstermanU, MitchellJA,. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad USA1991;88:10480–4.
16.
VallanceP, LeoneA, CalverA, CollierJ, MoncadaS: Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol1992;20(12 Suppl):S60–2.
17.
Bode-BögerSM, BögerRH, KienkeS, JunkerW, FrölichJC. Elevated L-arginine/ dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. Biochem Biophys Res Comm1996;219:598–603.
18.
BogerRH, Bode-BogerSM, SxubaA, TsaoPS, ChanJR, TangphaoO, BlaschkeTF, CookeJP. ADMA: a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia [abstract]. Circulation1998;96s:A173.
19.
MatsuokaH, ItohS, KimotoM, KohnoK, TamaiO, WadaY,. Asymmetrical dimethlyarginine, an endogenous nitric oxide synthase inhibitor, in experimental hypertension. Hypertension1997;29:242–7.
20.
FaraciFM, BrianJE, HeistadDD. Response of cerebral blood vessels to an endogenous inhibitor of nitric oxide synthase. Am J Physiol1995;269:H1522–7.
21.
KuroseI, WolfR, GrishamMB, GrangerDN. Effects of an endogenous inhibitor of nitric oxide synthesis on postcapillary venules. Am J Physiol1995;268:H2224–31.
22.
BögerRH, Bode-BögerSM, TsaoPS, LinPS, ChanJR, CookeJP. An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes [abstract]. Circulation1997;96s:A1588.
23.
MacAllisterRJ, ParryH, KimotoM,. Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br J Pharmacol1996;119:1533–40.
24.
MaxwellAJ, CookeJP. Cardiovascular effects of L-arginine. Nephrology and Hypertension1998;7:63–70.
25.
AdamsMR, JessupW, McCredieR, RobinsonJ, SullivanD, CelermajerDS. Oral L-arginine improves endothelium-dependent dila tion and reduces monocyte adhesion to endothelial cells in young men with cornorary artery disease, [abstract]. J Am Coll Cardiol1997;29:387A.
26.
ChauhanA, MoreRS, MullinsPA, TaylorG, PetchC, SchofieldPM. Aging associated endothelial dysfunction in humans is reversed by L-arginine. J Am Coll Cardiol1996;28:1796–1804.
27.
VallanceP, LeoneA, CalverA, CollierJ, MoncadaS. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet1992;339(8793):572–5.
28.
FlavahanNA. Lysophosphatidylcholine modified G protein-dependent signaling in porcine endothelial cells. Am J Physiol1993;264:H722–7.
29.
GiaidA, SalehD. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med1995;333:214–6.
30.
PieperGM, SiebenichW, DondingerLA. Short-term oral admin istration of L-arginine reverses defective endothelium-dependent relaxation and cGMP generation in diabetes. Eur J Pharmacol1996;317:317–20.
31.
PedlliR, EbelM, CatapanoG, Dell'OmoG, DucciM, Del ChiccaM,. Pressor, renal, and endocrine effects of L-arginine in essential hypertensives. Eur J Clin Pharmacol1995;48:195–201.
32.
CasinoPR, KilcoyneCM, QuyyumiAA, HoegJM, PanzaJA. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation1993;88:2541–7.
33.
CookeJP, SingerAH, TsaoP,. Anti-atherogenic effects of L-arginine in the hypercholesterolemic rabbit. J Clin Invest1992;90:1168–72.
34.
WangB, SingerA, TsaoP,. Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbit. J Am Coll Cardiol1994;23:452–8.
35.
BögerRH, Bode-BögerSM, MüggeA,. Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production. Atherosclerosis1995;117:273–84.
36.
MaruiN, OffermanMK, SwerlickR,. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest1993;92:1866–72.
37.
LiH, CybulskyMI, GimbroneMAJr, LibbyPA. An atherogenic diet rapidly induces VCAM-1, a cytokine regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb1993;13:197–204.
ClancyRM, LeszczynskaP, PiziakJ, AbramsonSB. Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on NADPH oxidase. J Clin Invest1992;90:1116–21.
40.
PengHB, LibbyP, LiaoJK: Induction and stabilization of I kappa B alpha by nitric oxide mediates inhibition of NF-kappa B. J Biol Chem1995;270:14214–9.
41.
SpieckerM, PengH-B, LiaoJK. Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IKBa. J Biol Chem1997;272:30969–74.
StroesES, KasteleinJJ, CosenfinoF, KeenansHA, LuscherTF, RabellnkTJ. Tetrahydrobiopterin ameliorates in vivo endothelial function in hypercholesterolemic patients. Circulation1996;94:1–220.
44.
TsaoPS, BuitragoR, ChanJR, CookeJP. Fluid flow inhibits endothelial adhesiveness: nitric oxide and transcriptional regulation of VCAM-1. Circulation1996;94:1682–9.
