Sage Journals: Discover world-class research

Abstract

Background

Abdominal aortic aneurysm (AAA) is a deadly disease in the elderly population. Currently, the association between single nucleotide polymorphisms (SNPs) and the presence of AAAs has become a hot topic and is a concern for many researchers.

Method

We performed a document retrieval in PubMed, EMBASE, and the Cochrane Library (to January 2020). A total of 17 case-control reports on SNPs of AAAs and eight SNPs of correlation factors were selected. All essential data, including race, age, country, criteria of AAA diagnosis, method of AAA measurement, method of genotype detection, name of SNPs, minor allele frequency (MAF), Hardy Weinberg equilibrium (HWE) of the control group, and number of cases and control groups were extracted by two reviewers independently. The fixed-effect model and random-effect model were used to calculate the overall odds ratios (ORs) and 95% confidence intervals (CIs). The association between selected SNPs and the presence of AAAs was evaluated under different genetic models (dominant, codominant, recessive, overdominant, and allele models).

Results

A total of 17 articles (sample size ranging from to 42–665 AAA cases and 49–2,297 controls) and 23 SNPs of related factors were identified. Eight SNPs were assessed in at least two studies and were selected for further meta-analysis. We found that the A allele of interleukin (IL)-10 (−1082 G/A) (OR: 1.35, 95% CI: 1.18–1.54, p < 0.0001) was a risk factor for AAAs under random and fixed-effect models. In addition, partial genetic models of these SNPs were confirmed to be related to the presence of AAA. Subgroup analysis revealed that haptoglobin (HP)-1 was a risk factor for AAAs (OR: 1.30, 95% CI: 1.04–1.63, p = 0.02) in the European population. No association was found between the occurrence of AAA and the other SNPs.

Conclusion

In our current meta-analysis, we speculated that the genotype distribution of IL-10 (−1082 G/A) may be associated with the emergence of AAA.

Keywords

abdominal aortic aneurysm single nucleotide polymorphisms inflammatory

Get full access to this article

View all access options for this article.

References

Umebayashi

Uchida

Wada

. Abdominal aortic aneurysm in aged population. Aging 2018; 10(12): 3650–3651.

Karthikesalingam

Vidal-Diez

Ozdemir

, et al. Mortality from ruptured abdominal aortic aneurysms: clinical lessons from a comparison of outcomes in England and the USA. The Lancet 2014; 383(9921): 963–969.

Villard

Hultgren

. Abdominal aortic aneurysm: sex differences. Maturitas 2018; 109: 63–69.

Golledge

. Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol 2019; 16(4): 225–242.

Stoberock

Kölbel

Atlihan

, et al. Gender differences in abdominal aortic aneurysm therapy - a systematic review. Vasa 2018; 47(4): 267–272.

Hanrong

Bai

Shuling

Qiang

, et al. Modulation of immune-inflammatory responses in abdominal aortic aneurysm: emerging molecular targets, 2018, p. 7213760.

Davis

Rateri

Daugherty

. Abdominal aortic aneurysm. Curr Opin Cardiol 2015; 30(6): 566–573.

PanCheng

J-PTsai-Mu

Cheng

T-M

Chiang

S-C

, et al. Haptoglobin phenotypes and plasma haptoglobin levels in patients with abdominal aortic aneurysm. J Vasc Surg 2011; 53(5): 1189–1194.

Norrgård

Fröhlander

Beckman

, et al. Association between haptoglobin groups and aortic abdominal aneurysms. Hum Hered 1984; 34(3): 166–169.

10.

Kowalska

Habrowska-Górczyńska

Neumayer

, et al. Lower levels of Caveolin-1 and higher levels of endothelial nitric oxide synthase are observed in abdominal aortic aneurysm patients treated with simvastatin. Acta Biochim Pol 2018; 65(1): 111–118.

11.

Morris

Biros

Cronin

, et al. The association of genetic variants of matrix metalloproteinases with abdominal aortic aneurysm: a systematic review and meta-analysis. Heart 2014; 100(4): 295–302.

12.

Wang

Quan

Zhang

, et al. Association between polymorphisms in the interleukin-10 gene and risk of abdominal aortic aneurysm. Genet Mol Res 2015; 14(4): 17599–17604.

13.

Oszajca

Wroński

Janiszewska

, et al. The study of t-PA, u-PA and PAI-1 genes polymorphisms in patients with abdominal aortic aneurysm. Mol Biol Rep 2014; 41(5): 2859–2864.

14.

Moher

Liberati

Tetzlaff

, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 2010; 8(5): 336–341.

15.

Bown

Burton

Horsburgh

, et al. The role of cytokine gene polymorphisms in the pathogenesis of abdominal aortic aneurysms: a case-control study. J Vasc Surg 2003; 37(5): 999–1005.

16.

Smallwood

Allcock

van Bockxmeer

, et al. Polymorphisms of the interleukin-6 gene promoter and abdominal aortic aneurysm. Eur J Vasc Endovascular Surg 2008; 35(1): 31–36.

17.

Bown

Lloyd

Sandford

, et al. The interleukin-10-1082 ‘a’ allele and abdominal aortic aneurysms. J Vasc Surg 2007; 46(4): 687–693.

18.

Yoon

Tromp

Vongpunsawad

, et al. Genetic analysis of MMP3, MMP9, and PAI-1 in finnish patients with abdominal aortic or intracranial aneurysms. Biochem Biophysical Res Commun 1999; 265(2): 563–568.

19.

Rossaak

Van Rij

Jones

, et al. Association of the 4G/5G polymorphism in the promoter region of plasminogen activator inhibitor-1 with abdominal aortic aneurysms. J Vasc Surg 2000; 31(5): 1026–1032.

20.

Bridge

Macrae

Bailey

, et al. The alpha-2-antiplasmin Arg407Lys polymorphism is associated with abdominal aortic aneurysm. Thromb Res 2014; 134(3): 723–728.

21.

Fatini

Sofi

Sticchi

, et al. eNOS G894T polymorphism as a mild predisposing factor for abdominal aortic aneurysm. J Vasc Surg 2005; 42(3): 415–419.

22.

Atli

Manduz

Katrancioglu

, et al. eNOS G894T polymorphism and abdominal aortic aneurysms. Angiology 2010; 61(2): 125–130.

23.

Saratzis

Bown

Wild

, et al. Association between seven single nucleotide polymorphisms involved in inflammation and proteolysis and abdominal aortic aneurysm. J Vasc Surg 2015; 61(5): 1120–1128.

24.

Kotani

Shimomura

Murakami

, et al. Allele frequency of human endothelial nitric oxide synthase gene polymorphism in abdominal aortic aneurysm. Intern Med 2000; 39(7): 537–539.

25.

Powell

Bashir

Dawson

, et al. Genetic variation on chromosome 16 is associated with abdominal aortic aneurysm. Clin Sci 1990; 78(1): 13–16.

26.

Wiernicki

Safranow

Baranowska-Bosiacka

, et al. Haptoglobin 2-1 phenotype predicts rapid growth of abdominal aortic aneurysms. J Vasc Surg 2010; 52(3): 691–696.

27.

Marculescu

Sodeck

Domanovits

, et al. Interleukin-1 gene cluster variants and abdominal aortic aneurysms. Thromb Haemostasis 2005; 94(3): 646–650.

28.

Ren

Han

Ren

, et al. AEBP1 promotes the occurrence and development of abdominal aortic aneurysm by modulating inflammation via the NF-κB pathway. J Atherosclerosis Thrombosis 2019; 27(3): 255–270.

29.

Haller

Crawford

CourchaineCourchaine

, et al. Intraluminal thrombus is associated with early rupture of abdominal aortic aneurysm. J Vasc Surg 2018; 67(4): 1051–1058, e1.

30.

MA3RS Study Investigators . Aortic wall inflammation predicts abdominal aortic aneurysm expansion, rupture, and need for surgical repair. Circulation 2017; 136(9): 787–797.

31.

Macsweeney

. Mechanical properties of abdominal aortic aneurysm and prediction of risk of rupture. Cardiovasc Surg (London, England) 1999; 7(2): 158–159.

32.

Moris

Georgopoulos

. Circulating biomarkers for abdominal aortic aneurysm: what did we learn in the last decade? Int Angiology: J Int Union Angiology 2013; 32(3): 266–280.

33.

Jones

Brull

Brown

, et al. Interleukin-6 ( IL-6 ) and the prognosis of abdominal aortic aneurysms. Circulation 2001; 103(18): 2260–2265.

34.

Qiang

Wang

. Embelin inhibits abdominal aortic aneurysm through decreasing IL-6-induced STAT3 and NF-κB inactivation. Mol Med Rep 2018; 18(2): 2365–2372.

35.

KokjeKokje

VBC

Gäbel

Koole

, et al. IL-6: a janus-like factor in abdominal aortic aneurysm disease. Atherosclerosis 2016; 251: 139–146

36.

Fishman

Faulds

Jeffery

, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 102(7): 1369–1376.

37.

JoséRojas

Avia

Martín

, et al. IL-10: a multifunctional cytokine in viral infections, 2017. no. 6104054.

38.

Sziksz

Pap

Lippai

, et al. Fibrosis related inflammatory mediators: role of the IL-10 cytokine family, 2015. Mediators Inflamm, 2015, p. 764641.

39.

Zhu

Zhang

, et al. Interleukin-10 promotes proliferation of vascular smooth muscle cells by inhibiting inflammation in rabbit abdominal aortic aneurysm. Int J Clinical Experiment Pathology 2019; 12(4): 1260–1271.

40.

Adam

Kooreman

Jagger

, et al. Systemic upregulation of IL-10 (Interleukin-10) using a nonimmunogenic vector reduces growth and rate of dissecting abdominal aortic aneurysm. Arteriosclerosis, Thromb Vasc Biol 2018; 38(8): 1796–1805.

41.

Turner

Williams

Sankaran

, et al. An investigation of polymorphism in the interleukin-10 gene promoter. Eur J Immunogenet 1997; 24(1): 1–8.

42.

Janaszak-Jasiecka

Siekierzycka

Bartoszewska

, et al. eNOS expression and NO release during hypoxia is inhibited by miR-200b in human endothelial cells. Angiogenesis 2018; 21(4): 711–724.

43.

Han

W-Q

Chang

F-J

Wang

Q-R

, et al. Microparticles from patients with the acute coronary syndrome impair vasodilatation by inhibiting the Akt/eNOS-Hsp90 signaling pathway. Cardiology 2015; 132(4): 252–260.

44.

Che

Fang

Yan

, et al. Elevated pigment epithelium-derived factor induces diabetic erectile dysfunction via interruption of the Akt/Hsp90β/eNOS complex. Diabetologia 2020; 63(1): 1857–1871.

45.

Gao

Siu

Chalupsky

, et al. Role of uncoupled endothelial nitric oxide synthase in abdominal aortic aneurysm formation. Hypertension 2012; 59(1): 158–166.

46.

Tesauro

Thompson

Rogliani

, et al. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci 2000; 97(6): 2832–2835.

47.

Shih

AWY

McFarlane

Verhovsek

. Haptoglobin testing in hemolysis: measurement and interpretation. Am J Hematol 2014; 89(4): 443–447.

48.

Holme

AastveitAastveit

Hammar

, et al. Haptoglobin and risk of myocardial infarction, stroke, and congestive heart failure in 342,125 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). Ann Med 2009; 41(7): 522–532.

49.

Lee

HsuHuang

CMH-B

, et al. IL‐6 induces haptoglobin expression through activating STAT3 in human head and neck cancer. J Oral Pathol Med 2020; 49(1): 49–54.

50.

Belcher

Chen

Nguyen

, et al. Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. Plos One 2018; 13(4): e0196455.

51.

Langlois

Martin

Boelaert

, et al. The haptoglobin 2-2 phenotype affects serum markers of iron status in healthy males. Clin Chem 2000; 46(10): 1619–1625.

52.

Liu

Shi

Guo

, et al. [Association of haptoglobin 1/2 polymorphism with coronary heart disease in Chinese]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chin J Medical Genetics 2011; 28(1): 60–63.

53.

Farbstein

Blum

Pollak

, et al. Vitamin E therapy results in a reduction in HDL function in individuals with diabetes and the haptoglobin 2-1 genotype. Atherosclerosis 2011; 219(1): 240–244.

54.

Weng

L-C

Roetker

LutseyLutsey

, et al. Evaluation of the relationship between plasma lipids and abdominal aortic aneurysm: a mendelian randomization study. PLoS One 2018; 13(4): e0195719.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

0.20 MB

Association between gene polymorphism of inflammatory factors,thrombogenic factors,and stress-related proteins and abdominal aortic aneurysm: A meta-analysis and systematic review

Abstract

Background

Method

Results

Conclusion

Keywords

Get full access to this article

References

Supplementary Material