Common carotid artery (CCA) remodelling in the atherosclerosis process is an inherent necessary element that decreases the progress of significant lumen compromise. The present study used a semi-automated method to assess relationships of intima-media thickness (IMT), lumen diameter (LD) and inter-adventitial diameter (IAD) using ultrasound B-mode images of atherosclerotic carotid artery.
Methods
In the cross-sectional study, 120 male subjects (age range: 40–60 years) were classified into four research groups namely control, mild, moderate, and severe stenosis. The maximum near and far wall IMT, mean of both walls’ IMT and IAD, and also LD of the left CCA were extracted for all participants. Pearson correlation coefficient was utilized to investigate relationships of IMT, LD, and IAD.
Results
Results revealed that the maximum far and near wall IMT, mean of both walls’ IMT and IAD in the CCA were significantly different in stenosis patients and the control group (p< 0.001). However, there were no significant differences among the four studied groups in terms of LD of CCA (p = 0.65). There was a stronger correlation between mean of both walls’ IMT and IAD in comparison with mean far wall IMT and IAD (p < 0.001).
Conclusions
Results indicated that changes of IAD in the left CCA were associated with carotid deformation, and thus it can be considered as a predictor of atherosclerosis process.
SharmaMKasliwalRBansalM, et al.
Carotid intima-media thickness: current evidence, practices, and Indian experience. Indian J Endocr Metab2014;
18: 13
2.
RennaNFde Las HerasNMiatelloRM, et al.
Pathophysiology of vascular remodeling in hypertension. Int J Hypertens2013;
2013: 808353
3.
ZavodniAEHWassermanBAMcClellandRL, et al.
Carotid artery plaque morphology and composition in relation to incident cardiovascular events: the multi-ethnic study of atherosclerosis (MESA). Radiology2014;
271: 381–389.
4.
QinGLuoLLvL, et al.
Decision tree analysis of traditional risk factors of carotid atherosclerosis and a cutpoint-based prevention strategy.PLoS One2014;
9: e111769.
5.
BaldassarreDHamstenAVegliaF, et al.
Measurements of carotid intima-media thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events: results of the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events). J Am Coll Cardiol2012;
60: 1489–1499.
6.
EigenbrodtMLSukhijaRRoseKM, et al.
Common carotid artery wall thickness and external diameter as predictors of prevalent and incident cardiac events in a large population study. Cardiovasc Ultrasound2007;
5: 11
7.
Sutton-TyrrellKWolfsonSKThompsonT, et al.
Measurement variability in duplex scan assessment of carotid atherosclerosis. Stroke1992;
23: 215–220.
8.
KumarLANagarajanC.Common carotid artery intima media thickness segmentation survey. World Acad Sci Eng Technol Int J Medical, Heal Biomed Bioeng Pharm Eng2015;
8: 689–693.
9.
RafatiMBitarafan-RajabiAHamiK.Performance intima-media thickness of carotid artery and flow mediated dilation of brachial artery for assessing atherosclerosis progression. J Med Imaging Hlth Inform2014;
4: 724–732.
10.
YamashitaAShojiKTsurudaT, et al.
Medial and adventitial macrophages are associated with expansive atherosclerotic remodeling in rabbit femoral artery. Histol Histopathol2008;
23: 127–136.
11.
RafatiMRafati RahimzadehMRayganF, et al.
A New 2D-based method for carotid intima-media thickness quantification from ultrasound sequences. Iran Red Crescent Med J2015;
17: e24691
12.
HögbergDDellagrammaticasDKragstermanB, et al.
Simplified ultrasound protocol for the exclusion of clinically significant carotid artery stenosis. Ups J Med Sci2016;
121: 165–169.
13.
RafatiMHavaeeEMoladoustH, et al.
Appraisal of different ultrasonography indices in patients with carotid artery atherosclerosis. Excli J2017;
16: 727–741.
14.
TouboulP-JHennericiMGMeairsS, et al.
Mannheim carotid intima-media thickness consensus (2004–2006). An update on behalf of the Advisory Board of the 3rd and 4th watching the risk symposium, 13th and 15th European Stroke conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis2007;
23: 75–80.
15.
MolinariFZengGSuriJS.A state of the art review on intima-media thickness (IMT) measurement and wall segmentation techniques for carotid ultrasound. Comput Methods Programs Biomed2010;
100: 201–221.
16.
RochaRCampilhoASilvaJ, et al.
Segmentation of the carotid intima-media region in B-mode ultrasound images. Image Vis Comput2010;
28: 614–625.
17.
LisowskaAKnappMBolińskaS, et al.
The importance of intima-media thickness (IMT) measurements in monitoring of atherosclerosis progress after myocardial infarction. Adv Med Sci2012;
57: 112–117.
18.
IleaDEDuffyCKavanaghL, et al.
Fully automated segmentation and tracking of the intima media thickness in ultrasound video sequences of the common carotid artery. IEEE Trans Ultrason Ferroelectr Freq Control2013;
60: 158–177.
19.
ÖzcanCDeleskogASchjerning OlsenA-M, et al.
Coronary artery disease severity and long-term cardiovascular risk in patients with myocardial infarction: a Danish nationwide register-based cohort study. Eur Hear J – Cardiovasc Pharmacother2018;
4: 25–35.
20.
MagnoniMColiSMarrocco-TrischittaMM, et al.
Contrast-enhanced ultrasound imaging of periadventitial vasa vasorum in human carotid arteries. Eur J Echocardiogr2008;
10: 260–264.
21.
EigenbrodtMLBursacZTracyRE, et al.
B-mode ultrasound common carotid artery intima-media thickness and external diameter: cross-sectional and longitudinal associations with carotid atherosclerosis in a large population sample. Cardiovasc Ultrasound2008;
6: 10
22.
PolakJFWongQJohnsonWC, et al.
Associations of cardiovascular risk factors, carotid intima-media thickness and left ventricular mass with inter-adventitial diameters of the common carotid artery: the Multi-Ethnic Study of Atherosclerosis (MESA). Atherosclerosis2011;
218: 344–349.
23.
EigenbrodtMLEvansGWRoseKM, et al.
Bilateral common carotid artery ultrasound for prediction of incident strokes using intima-media thickness and external diameter: an observational study. Cardiovasc Ultrasound2013;
11: 22
24.
SchottLLKaoAHCunninghamA, et al.
Do carotid artery diameters manifest early evidence of atherosclerosis in women with rheumatoid arthritis?J Womens Health (Larchmt)2009;
18: 21–29.
Rodríguez HernándezSAKroonAAvan BoxtelMPJ, et al.
Is there a side predilection for cerebrovascular disease?Hypertens2003;
42: 56–60.
27.
GlagovSWeisenbergEZarinsCK, et al.
Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med1987;
316: 1371–1375.
28.
EghbaliehSDDChowdharyPMutoA, et al.
Age-related neointimal hyperplasia is associated with monocyte infiltration after balloon angioplasty. J Gerontol Ser A Biol Sci Med Sci2012;
67A: 109–117.
29.
SaitoDOkaTKajiyamaA, et al.
Factors predicting compensatory vascular remodelling of the carotid artery affected by atherosclerosis. Heart2002;
87: 136–139.
30.
KorshunovVABerkBC.Flow-induced vascular remodeling in the mouse: a model for carotid intima-media thickening. Arterioscler Thromb Vasc Biol2003;
23: 2185–2191.
