The present report describes the successful treatment of cerebral symptomatic vasospasm (SVS) after subarachnoid hemorrhage (SAH) with super-selective intra-arterial infusion of fasudil hydrochloride (ERIL®). We treated seventeen vascular territories in 12 patients with selective intra-arterial infusion of fasudil hydrochloride (FSD). FSD was infused through a catheter (a microcatheter in nine patients) at a rate of 1.0 to 1.5 mg / minute (total dose = 30 to 60 mg / 1 vessel) for each vascular territory. Nineteen vascular territories (100%) were angiographically dilated and seven patients (58%) showed early improvement in neurological function after the procedure.
KassellNFHelmG: Treatment of cerebral vasospasm with intra-arterial papaverine. J Neurosurg77: 848–852, 1992.
2.
KakuYYoneyamaY: Superselective intra-arterial infusion of papaverine for the treatment of cerebral vasospasm after subarachnoid hemorrhage. J Neurosurg77: 842–847, 1992.
3.
BeckDWAdamsHP: Combination of aminocaproic acid and nicardipine in treatment of aneurysmal subarachnoid hemorrhage. Stroke19: 63–67, 1988.
4.
FisherCMKistlerJP: Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery6: 1–9, 1980.
5.
SashidaJNagataK: Selective intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm. Jpn J Med Pharm Sci39: 593–599, 1998.
6.
ShibuyaMSuzukiY: Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Neurosurgery76: 571–577, 1992.
7.
SetoMOnoT: Inhibition of Myosin Light Chain Phosphorylation by Fasudil Hydrochloride. Jpn Pharmacol Ther20: 1551–1555, 1992.
