Vein-Loaded Stent System to Occlude Wide-Necked Aneurysms

Abstract

We devised a vein-loaded stent system to immediately close the aneurysmal orifice without interrupting the parent arterial flow. Ten experimental wide-necked aneurysms located on canine common carotid arteries were treated with the implantation of a newly modified vein-loaded stent system. After deploying the stent, half of them were managed under administration of 50 mg of ticlopidine hydrochloride per day and the other half followed up without any anticoagulation therapy. Immediately after the stent placement, all aneurysms were completely obliterated with patency of the parent artery in the successfully implanted vessels in both groups.

Follow-up angiography one week later disclosed complete occlusion of the aneurysm with patency of the parent artery in 67% (2/3) of the group with ticlopidine, while none of the group without drugs showed patency of the parent artery. The rate of patency of the parent artery was found to be improved by administration of ticlopidine, but was still lower than that of a conventional stent. Further modifications will be needed before clinical use.