We developed new embolic drug delivery emulsions to be utilized for malignant neoplasms.
We combined additional water-soluble contrast materials (Ioxaglic acid, Iopamidol) with Glyceol, Poloxamer-188, or D-Mannitol to antitumor agent Lipiodol ultrafluid in order to generate stable emulsions.
Some of these emulsions have been shown to cause pulmonary embolism in rabbits and to allow gradual diffusion of the antitumor agent in vitro.
Good therapeutic utility is indicated. In particular, one emulsion containing D-Mannitol (Mizonokuchi emulsion), is expected to prolong drug delivery in malignant brain tumors.
KonnoT: Targeting chemotherapy for hepatocellular carcinoma by arterial administration of anticancer agents dissolved in Lipiodol. Jpn J Cancer Chemother14: 373–380, 1987.
2.
KodamaTArimaK: A Pharmacological and clinical studies on lipiodol emulsion for hepatocellular carcinoma. Jpn J Cancer Chemother15: Part II, 2544–2548, 1988.
3.
KonnoT: Selective drug targeting of anticancer drug and simultaneous image enhancement in solid tumor by arterially administrated lipid contrast medium. Cancer54: 2367–2374, 1985.
4.
OhishiH: Hepatocellular carcinoma detected by iodized oil: Use of anticancer agents. Radiology154: 25–29, 1985.
5.
YamashitaJ: Intra-arterial ACNU therapy for malignant brain tumors. Experimental studies and preliminary clinical results. J Neurosurg59: 424–430, 1983.
