Change in management for digital subtraction angiography-identified false-positive traumatic vertebral artery injury

Abstract

Background

For patients with suspected traumatic vertebral artery injury (TVAI), CT angiography (CTA) is the first-line screening modality. Digital subtraction angiography (DSA) serves as the confirmatory diagnostic imaging, and is the gold standard for cerebrovascular injury assessment, due to its higher sensitivity and specificity. Among patients with TVAI based on CTA who have undergone follow-up DSA, this study aims to investigate how diagnostic information with additional imaging affects clinical management.

Methods

A retrospective review was conducted over 7 years (2016–2023) at a level 1 trauma center for TVAI patients undergoing both CTA and DSA. Pre- and post-DSA approaches to TVAI management were compared and summarized using propensity-score matched analysis.

Results

Among the 69 patients studied, 24.6% were determined to have false-positive TVAI after DSA. The rate of change in management after DSA was significantly different across DSA+ and DSA- cohorts (p = 0.02). The likelihood of a change in management in patients with based on outcome of the DSA was significant (p = 0.03) in the propensity-matched cohort. On average, 3 (NNI = 3.2) patients would need to receive a DSA for one additional patient to undergo a change in management.

Conclusion

This study demonstrates that, despite initial CTA imaging suggestive of TVAI, follow-up DSA imaging negative for TVAI has a significant impact on changing clinical management, including cessation of antithrombotic agents. Thus, for TVAI patients, DSA may be considered in the diagnostic workup for select patients with positive CTA. Larger cohort analyses are needed to refine imaging algorithms and optimize clinical outcomes for TVAI patients.