Comparison of the imaging performance of time-of-flight MRA and ultrashort echo time MRA in flow diverters: A phantom study

Abstract

Objective

Flow diverters (FD) are innovative treatments for wide-neck intracranial aneurysms. After-treatment verification of embolization and parent vessel patency is crucial. While evaluation using time-of-flight magnetic resonance angiography (TOF-MRA) is useful, it suffers from signal loss within the FD due to susceptibility effects. This study evaluates the usefulness of ultrashort echo time MRA (UTE-MRA) for after-FD assessment compared to TOF-MRA.

Methods

Vascular phantom experiments were conducted using FDs (FRED^®, Pipeline^®, Surpass Streamline^®). TOF-MRA and UTE-MRA were performed under steady (10, 30, 50 cm/s) and pulsatile (17–61 cm/s, mean 34 cm/s) flow conditions using a 3 T MRI system. As evaluation metrics, relative in-FD signal (RIS) was calculated by comparing the signal intensity inside the FD to that without the FD to assess signal retention, and FD luminal to background signal ratio (FD-LBR) was calculated by comparing the signal intensity inside the FD to that of the surrounding background to evaluate vessel visibility.

Results

UTE-MRA showed higher FD-LBR values than TOF-MRA for all FDs (p < 0.01). For RIS, UTE-MRA was significantly higher for FRED^® (p < 0.01), but different for other FDs except at 50 cm/s. FRED^® exhibited the highest RIS and FD-LBR values under all conditions, followed by Pipeline^® and Surpass Streamline^®. Flow velocity changes resulted in minimal variations in RIS and FD-LBR values.

Conclusion

UTE-MRA provides superior image quality for after-FD assessment, particularly in terms of FD-LBR, compared to TOF-MRA. Differences in FD materials and structures affect image quality. These findings suggest UTE-MRA's clinical utility in follow-up after-FD assessment.