Morphologic and Hemodynamic Changes after Stent Placement for Experimental Carotid Aneurysm

Abstract

Stent assisted coil embolization is useful in treating broad neck aneurysms, and there are many kinds of stents that can be applied in the cerebral artery, however their characteristics are not well known. We investigated and compared morphologic and hemodynamic changes before and after stent placement when several different kinds of stents were applied to experimental aneurysms.

Experimental aneurysms in eight pig carotid arteries were used. Stents were placed covering the aneurysm orifice. Five Cordis stents (coil stent), two GFXs (multilink stent), and one Multilink (tube stent) were used in this study. After coil placement, the arteries were perfused with 70% ethanol, the specimens were embedded in polyester plastic resin and thin slices were stained with hematoxylin-eosin. Blood flow in the aneurysm was measured using digital subtraction angiography.

The parent artery was stretched in multilink stent (GFX) cases, and was most markedly stretched by use of the tube stent (Multilink). Stent placement with any type of stent decreased intra-aneurysmal blood flow.

Keywords

cerebral aneurysm stent

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References

Aenis

Stancampiano

: Modeling of flow in a straight stented and nonstented side wall aneurysm model. J Biomech Eng 119: 206–212, 1997.

Asakura

Tenjin

: Experimental saccular aneurysms in pig carotid arteries. J Kyoto Pref Med 105: 963–967, 1996.

Bracard

Anxionnat

: Combined endovascular stenting and endovascular coiling for the treatment of a wide-necked intracranial vertebral aneurysm: Technical case report. Interven Neurordiol 5: 245–249, 1999.

Guglielmi

Vinuela

: Electrothrombosis of saccular aneurysms via endovascular approach. J Neurosurg 75: 8–14, 1991.

Higashida

Smith

: Intravascular stent and endovascular coil placement for a ruptured fusiform aneurysm of the basilar artery: Case report and review of the literature. J Neurosurg 87: 944–949, 1997.

Lieber

Stancampiano

: Alteration of hemodynamics in aneurysm models by stenting: Influence of stent porosity. Ann Biomed Eng 25: 460–469, 1997.

Mericle

Lanzino

: Stenting and secondary coiling of intracranial internal carotid artery aneurysm: Technical case report. Neurosurgery 43: 1229–1234, 1998.

Massoud

Turjman

: Endovascular treatment of fusiform aneurysms with stents and coils: Technical fesibility in a swine model. Am J Neuroradiol 16: 1953–1963, 1995.

Sekhon

LHS

Morgan

: Combined endovascualr stent implantation and endosaccular coil placement for treatment of a wide-necked vertebral artery aneurysm: Technical case report. Neurosurgery 43: 380–384, 1998.

10.

Tenjin

Asakura

: Evaluation of intra-aneurysmal blood velocity by time density curve using digital subtraction angiography. Am J Neuroradiol 19: 1303–1307, 1998.

11.

Turjman

Massoud

: Combined stent implantation and endovascular coil placement for treatment of experimental wide necked aneurysms: A feasibility study in swine. Am J Neuroradiol 15: 1087–1090, 1994.

12.

Zubillaga

Guglielmi

: Endovascular occlusion of intracranial aneurysms with electrically detachable coils: Correlation of aneurysm neck size and treatment results. Am J Neuroradiol 15: 815–820, 1994.