A case of dural sinus thrombosis complicated with heparin induced thrombocytopenia and thrombosis (HITT) is presented. Interventional neuroradiologic procedures have potential risks of this devastating complication that is related with heparin. Clinical features and pathophysiologic mechanisms of HITT are discussed.
WalengaJMBickRL: Heparin-induced thrombocytopenia, paradoxical thromboembolism, and other side effects of heparin therapy. Med Clin North Am82: 635–658, 1998.
2.
WarkentinTELevineMN: Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin. N Engl J Med332: 1330–1335, 1995.
3.
JacksonMRGillespieDL: The incidence of heparin-induced antibodies in patients undergoing vascular surgery: a prospective study. J Vasc Surg28: 439–444, 1998.
4.
Kappers-KlunneMCBoonDM: Heparin-induced thrombocytopenia and thrombosis: a prospective analysis of the incidence in patients with heart and cerebrovascular diseases. Br J Haematol96: 442–446, 1997.
5.
van SambeekMRSegerenCM: Endovascular repair of an extracranial internal carotid artery aneurysm complicated by heparin-induced thrombocytopenia and thrombosis. J Endovasc Ther7: 353–358, 2000.
6.
SeidenstickerDWilcoxJGagneP: Treatment of May-Thurner syndrome with catheter-directed thrombolysis and stent placement, complicated by heparin-induced thrombocytopenia. Cardiovasc Surg6: 607–613, 1998.
7.
VisentinGPFordSE: Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. J Clin Invest93: 81–88, 1994.
8.
SlaughterTFGreenbergCS: Heparin-associated thrombocytopenia and thrombosis: implications for perioperative management. Anesthesiology87: 667–675, 1997.
9.
MakhoulRGGreenbergCSMcCannRL: Heparin-associated thrombocytopenia and thrombosis: a serious clinical problem and potential solution. J Vasc Surg4: 522–528, 1986.
10.
PohlCHarbrechtU: Neurologic complications in immune-mediated heparin-induced thrombocytopenia. Neurology54: 1240–1245, 2000.
11.
WarkentinTEKeltonJG: A 14-year study of heparin-induced thrombocytopenia. Am J Med101: 502–507, 1996.
12.
MelansonSWSilverBHellerMB: Deep vein thrombosis, pulmonary embolism, and the white clot syndrome. Am J Emerg Med14: 558–560, 1996.
