An endovascular model for producing and studying middle cerebral artery acute ischemic strokes was developed to avoid the need for an open surgical approach to the middle cerebral, anterior cerebral, posterior cerebral and internal carotid arteries. Endovascular occlusion of these vessels followed by Xenon-CT cerebral blood flow study confirmed the production of a middle cerebral artery distribution infarct in two primates. The methodology, advantages and drawbacks of this model are discussed.
SymonL: Experimental model of stroke in the baboon. In Advances in Neurology, vol 10. MeldrumBS and MarsdenCD (ed) Raven Press, New York199–212, 1975.
2.
SymonLPasztorEBranstonNM: The distribution and density of reduced cerebral blood flow following acute middle cerebral artery occlusion: An experimental study of the technique of hydrogen clearance in baboons. Stroke5: 355–363, 1974.
3.
Del ZoppoGJCopelandBR: Experimental acute thrombotic stroke in baboons. Stroke17: 1254–1265, 1986.
