Risks and Abuses of Megadoses of Vitamins

The therapeutic uses of vitamin A. Acta Dermato-Venereologica 1975; 55(suppl. 74): 11–185.

Sporn M.B. , Newton D.L. Chemoprevention of cancer with retinoids. Fed Proc 1979; 38: 2528–2534.

Bollag W. Retinoids and cancer. Cancer Chem Pharm 1979; 3: 207–215.

Peta R. , Doll R. , Buckley I.D. , Sporn M.B. Can dietary beta-carotene materially reduce human cancer rates? Nature 1981; 290: 201–208.

Wolf G. Vitamina A. In: Alfin-Slater R.B. , Kritchevsky D. , eds. Human nutrition. Vol. 3B, Nutrition and the adult: micronutrients. New York: Plenum Press, 1980: 97–203.

McLaren D.S. Vitamin A deficiency and toxicity. In: Present knowledge in nutrition. 5th ed. Washington, DC: The Nutrition Foundation, 1984: 192–208.

Arroyave G. , Bauernfeind J.C. , Olson J.A. , Underwood B.A. Selection of intervention strategies. In: Guidelines for the eradication of vitamin A deficiency and xerophthalmia. A report of the International Vitamin A Consultative Group. Washington, DC: The Nutrition Foundation, 1976: 11/1–11/8.

Jeghers H. , Marraro H. Hypervitaminosis A: its broadening spectrum. Am J Clin Nutr 1958; 6: 335–339.

Korner W.F. , Volm J. New aspects of the tolerance of retinol in humans. Int J Vit Nutr Res 1975; 45: 363–372.

Moore T. Vitamina A. London: Elsevier, 1957: 442–455.

Bernhardt I.B. , Dorsey D.J. Hypervitaminosis A and congenital renal anomalies in human infants. Obstet Gynecol 1974; 43: 750–755.

Strange L. , Cartlstrom K. , Eriksson M. Hypervitaminosis A in early human pregnancy and malformations of the central nervous system. Acta Obstet Gynecol Scand 1978; 57: 289–291.

Underwood B.A. The safe use of vitamin A by women during the reproductive years. In: A report prepared for the International Vitamin A Consultative Group (IVACG). Washington, DC: The Nutrition Foundation, 1986.

WHO- UNICEF- USAID-Helen Keller International-IVACG. Meeting report: control of vitamin A deficiency and xerophthalmia. World Health Organization technical report series no. 672. Geneva: WHO. 1982.

Bauernfeind J.C. The safe use of vitamin A. A report of the International Vitamin A Consultative Group (IVACG). Washington, DC: The Nutrition Foundation, 1982.

American Academy of Pediatrics. The use and abuse of vitamin A. Pediatrics 1971; 48: 655–656.

National Research Council. Recommended dietary allowances. 9th ed. Washington, DC: National Academy of Sciences, 1980.

De Luca H.F. Vitamin D. In: Alfin-Slater R.B. , Kritchevsky D. , eds. Human nutrition. Vol. 3B, Nutrition and the adult: micronutrients. New York: Plenum Press, 1980: 205–244.

Davie M. , Lawson D.E.M. Assessment of plasma 25-hydroxyvitamin D response to ultraviolet irradiation over a controlled area in young and elderly subjects. Clin Sci 1980; 58: 235–242.

Olson J.A. Vitamin K. In: Alfin-Slater R.B. , Kritchevsky D. , eds. Human nutrition. Vol. 3B, Nutrition and the adult: micronutrients. New York: Plenum Press, 1980: 267–286.

American Academy of Pediatrics, Committee on Nutrition. Vitamin K supplementation for infants receiving milk substitute formulas and for those with fat malabsorption. Pediatrics 1971; 48: 483–487.

Vitamin K and the newborn. Nutr Rev 1972; 30: 131–133.

Owen C.A. Vitamin K pharmacology and toxicology. In: Sebrell W.H. , Harris R.S. , eds. The vitamins. Vol. 3. New York: Academic Press, 1971: 492–509.

Machlin L.J. , Brin M. Vitamin E. In: Alfin-Slater R.B. , Kritchevsky D. , eds. Human nutrition. Vol. 3B, Nutrition and the adult: micronutrients. New York: Plenum Press, 1980: 245–266.

Gabriel E. , Machlin L.J. , Filipski R. Nelson J. Influence of age on the vitamin E requirement for resolution of necrotizing myopathy. J Nutr 1980; 110: 1372–1379.

Farrell P.M. , Bieri J.G. Megavitamin supplementation in man. Am J Clin Nutr 1975; 28: 1381–1386.

Pauling L. The significance of the evidence about ascorbic acid and the common cold. Proc Natl Acad Sci 1971; 68: 2678–2681.

Cameron E. , Pauling L. Ascorbic acid and cancer. Proc Am Philos Soc 1979; 123: 117–123.

Milner G. Ascorbic acid in chronic psychiatric patients: controlled trial. Brit J Psychiat 1963; 109: 294299.

Ginter E. , Cerna O. , Budlovsky J. Effect of long-term ascorbic acid on plasma cholesterol in humans in a long-term experiment. Int J Vitam Nutr Res 1977; 47: 123–133.

Sauberlich H.E. Ascorbic acid. In: Present knowledge in nutrition. 5th ed. Washington, DC: The Nutrition Foundation, 1984: 260–272.

Anderson W. Large-scale trial of vitamin C. Ann NY Acad Sci 1975; 258: 498–504.

Coulehan J.L. , Eberhard S. , Kapner L. , Taylor F. , Rogers K. , Garry P. Vitamin C and acute illness in Navajo school children. New Engl J Med 1976; 295: 973–977.

Hodges R.E. , Hood J. , Canham J.E. , Sauberlich H.E. , Baker E.M. Clinical manifestations of ascorbic acid deficiency in man. Am J Clin Nutr 1971; 24: 432–443.

Paterson V.E. , Crapo P.A. , Weininger J. Ginsberg H. Olefsky J. Quantification of plasma cholesterol and trigliceride levels in hypercholesterol subjects receiving ascorbic acid supplements. Am J Clin Nutr 1975; 28: 584–587.

Stein H.B. , Hasan A. , Fox I.H. Ascorbic acid-induced uricosuria. Ann Intern Med 1976; 84: 385–388.

Briggs M.H. , Garcia-Webb P. Davies P. Urinary oxalate and vitamin C supplements. Lancet 1973; ii: 201.

Cambpell G.D. , Steinberg M.H. , Bower J.D. Ascorbic acid-induced hemolysis in G-6-PD deficiency. Ann Intern Med 1975; 82: 810.

Shilotri P.G. , Bhat K.S. Effect of megadoses of vitamin C on bactericidal activity of leukocytes. Am J Clin Nutr 1977; 30: 1077–1081.

Cochrane W. Overnutrition in prenatal and neonatal life. Can Med Assoc J 1965; 93: 893–899.

Hines J.D. Ascorbic acid and vitamin B-12 deficiency. J Am Med Assoc 1975; 234: 24.

Cook J.D. , Monsen E.R. Vitamin C, the common cold. and iron absorption. Am J Clin Nutr 1977; 30: 235241.

Alhadeff L. , Gualtieri T.C. , Lipton M. Toxic effects of water-soluble vitamins. Nutr Rev 1984; 42: 33–40.

American Psychiatric Association Task Force on Vitamin Therapy in Psychiatry. Megavitamin and orthomolecular therapy in psychiatry.

The Coronary Drug Project Research Group. Clofibrate and niacin in coronary artery disease. J Am Med Assoc 1975; 231: 360–381.

Einstein N. , Baker A. , Galper J. , Wolfe H. Jaundice due to nicotinic acid therapy. Am J Digest Dis 1975; 20: 282286.

Gilman A.G. , Goodman L.S. , Gilman A. The pharmacological basis of therapeutics. New York: McMillan, 1980: 1331–1346.

Herbert V. , Coleman N. , Jacob E. In: Goodman R.S. , Shils M.E. , eds. Modern nutrition in health and disease. Philadelphia: Lea & Febiger, 1980: 229–259.

Mahoney M.J. , Rosenberg L.E. Inherited Defects of B-12 metabolism. Am J Med 1980; 48: 584–593.

Cottrell J.E. , Casthelly P. , Brodie J.D. , Klein A. , Turndorf H. Prevention of nitroprusside-induced cyanide toxicity with hydroxicobalamine. New Engl J Med 1978; 298: 809.

Herbert V. Vitamin B-12. In: Present knowledge in nutrition. 5th ed. Washington, DC: The Nutrition Foundation, 1984: 347–364.

Schaumburg H. , Kaplan J. , Winderbank A. Sensory neuropathy from pyridoxine abuse. New Engl J Med 1983; 309: 445–448.

Hunt AD Jr. , Stokes J. Jr. , McCrory WW , Stroud HH . Pyridoxine dependency: report of a case of intractable convulsions in an infant controlled by pyridoxine. Pediatrics 1954; 13: 140–145.

Canham J.E. , Nunes W.T. , Eberlin E.W. Electroencelographic and central nervous system manifestations of vitamin B-6 dependency in normal human adults. In: Proceedings of the Vl International Congress of Nutrition. Edinburgh: E. & S. Livingston Ltd., 1964: 537.