Physical Activity for Cardiovascular Risk Factor Reduction

Doll R Hill AB . Smoking and carcinoma of the lung; preliminary report. Br Med J. 1950;2(4682):739–748. doi:10.1136/bmj.2.4682.739

Morris JN Heady JA Raffle PA Roberts CG Parks JW . Coronary heart-disease and physical activity of work. Lancet. 1953;262(6795):1053-1057. doi:10.1016/s0140-6736(53)90665-5

Morris JN Heady JA Raffle PA Roberts CG Parks JW . Coronary heart-disease and physical activity of work. Lancet. 1953;262(6796):1111-1120. doi:10.1016/s0140-6736(53)91495-0

Paffenbarger JRS Laughlin ME Gima AS Black RA . Work activity of longshoremen as related to death from coronary heart disease and stroke. N Engl J Med. 1970;282(20):110-114. doi:10.1056/NEJM197005142822001

Paffenbarger JRS Hale WE . Work activity and coronary heart mortality. N Engl J Med. 1975;292(11):545-550. doi:10.1056/NEJM197503132921101

Physical Activity Guidelines Advisory Committee . Physical Activity Guidelines Advisory Committee Scientific Report. Washington, DC: US: Department of Health and Human Services; 2018.

Sallis R Rohm Young D Tartof SY , et al. Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients. Br J Sports Med. 2021;55(19):1099-1105. doi:10.1136/bjsports-2021-104080

Ezzatvar Y Ramírez-Vélez R Izquierdo M Garcia-Hermoso A . Physical activity and risk of infection, severity and mortality of COVID-19: a systematic review and non-linear dose–response meta-analysis of data from 1 853 610 adults. Br J Sports Med. 2022. doi:10.1136/bjsports-2022-105733

Centers for Disease Control and Prevention . Underlying conditions and the higher risk for severe COVID-19. https://www.cdc.gov/covid/hcp/clinical-care/underlying-conditions.html. Updated February 6, 2025. Accessed July 2, 2025.

U.S. Department of Health and Human Services . Physical Activity Guidelines for Americans. 2nd ed. Washington, DC: U.S. Department of Health and Human Services; 2018.

Webber BJ Yun HC Whitfield GP . Leisure-time physical activity and mortality from influenza and pneumonia: a cohort study of 577 909 US adults. Br J Sports Med. 2023;57(19):1231-1237. doi:10.1136/bjsports-2022-106644