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Abstract

Purpose. To evaluate changes in walk test performance and blood pressure (BP) responses following a 12-week exercise-based outpatient cardiac rehabilitation (CR) program. Methods. Six-Minute Walk Test (6MWT) and resting systolic BP (SBP), diastolic BP (DBP), post-6MWT heart rate (HR), and post-6MWT BPs were measured before and after CR in 311 (237 men,74 women) patients. Using age as a covariate, 2 by 2 (Gender × Measurement) ANCOVAs were used to determine differences in 6MWT performance and hemodynamic variables. Results. After adjusting for age, men covered a greater 6MWT distance than women; pre-CR versus post-CR program values are as follows: men, 429.3 ± 94.6 versus 557.6 ± 90.7 m, P ≤ .001; women, 374.9 ± 100.7 versus 483.2 ± 82.9 m, P ≤ .001. Both genders reduced resting DBP following the CR program (men: 67.2 ± 9.8 vs 65.6 ± 8.5 mm Hg, P = .034; women: 69.2 ± 10.7 vs 65.0 ± 8.0 mm Hg, P = .001) and increased HR following the 6MWT after the CR program (men: 97.7 ± 16.8 vs 112.7 ± 21.3 bpm, P ≤ .001; women: 100.7 ± 20.8 vs 110.2 ± 22.0 bpm, P ≤ .001). Similarly, SBP increased immediately following the 6MWT (122.8 ± 18.5 vs 133.6 ± 20.7 mm Hg; P ≤ .001) in men but not in women. Conclusion. The present findings indicate similar relative improvements in 6MWT performance and BP responses in adherent men and women following an exercise-based CR program.

Keywords

cardiac rehabilitation functional capacity blood pressure responses

‘Improvements in BP responses after 2, 3, or 6 months of CR have been reported in cardiac patients with and without heart failure.’

Introduction

Cardiovascular disease (CVD) represents one of the leading causes of death in men and women, and coronary artery disease (CAD) is the most prevalent etiology (63%). Myocardial infarction (MI) accounts for 38.5% of all CVD deaths and is more prevalent in men (62%) than women (38%).¹ A traditional 12-week exercise-based cardiac rehabilitation (CR) program provides a safe and effective treatment intervention for patients with CVD and has consistently been shown to reduce mortality, blood pressure (BP), CVD risk factors, and associated hospital admissions.^2-5 Exercise-based CR also increases functional capacity and walk test performance distance in men and women.^6-11 Some studies suggest that the post-CR improvements in functional capacity and walking distance are greater in men than women.^7,10 Gee et al¹⁰ evaluated whether the improvement in functional capacity following exercise-based CR varied between men and women with ischemic heart disease and reported that men demonstrated greater increases, expressed as peak metabolic equivalents (METs). Similarly, Gupta et al⁷ found that men covered greater distances in walk performance tests than women following CR. In contrast, O’Farrell et al¹² reported no difference in functional capacity improvements between men and women after 3 months of exercise-based CR.

The 6-Minute Walk Test (6MWT) provides a safe and simple field test that is widely used in CR to estimate functional capacity in cardiac patients with and without heart failure.^6-8,13 Improvement in timed walking distance following exercise-based CR provides an independent predictor of prognosis after MI in men.⁹ Moreover, slower gait and walking speeds are strong predictors of increased mortality in men and women.^14,15 Yazdanyar et al¹⁴ evaluated the association between 6MWT performance and all-cause mortality, coronary heart disease (CHD) mortality, and incident CHD in 1665 participants enrolled in the Cardiovascular Health Study. During an 8-year follow-up, there were 305 CHD events, 100 CHD deaths, and 504 all-cause deaths. Participants in the bottom 2 6MWT quintiles (<290 m and 290-338 m) demonstrated an increased all-cause mortality, with hazard ratios of 2.1 and 1.7, respectively.

Improvements in BP responses after 2, 3, or 6 months of CR have been reported in cardiac patients with and without heart failure.^8,16-18 Ghashghaei et al⁸ evaluated the effectiveness of a CR program on walk test performance and BP responses in patients who had undergone coronary artery bypass graft surgery. After 2 months of CR, the study cohort demonstrated a 19.2% increase in the 6MWT, an 11% reduction in resting systolic BP (SBP), and a 9% decrease in diastolic BP (DBP). Moreover, maximal SBP and DBP were significantly lower following CR. Another randomized controlled study of 118 coronary patients (99 men, 19 women) who were postcoronary angioplasty reported a 4.7% reduction in resting SBP in the training group after 6 months of exercise-based CR.¹⁷ A systematic review and meta-analysis that included 48 studies and 8940 patients revealed that SBP was significantly reduced following CR (weighted mean difference = −3.2 mm Hg; 95% CI: −5.4 to −0.9 mm Hg); however, DBP remained unchanged (weighted mean difference = −1.2 mm Hg; 95% CI: −2.7 to 0.3 mm Hg).³ A previous report in cardiac patients completing a 3-month CR program found 3.6% and 2.9% reductions in SBP and DBP, respectively, and attenuated exercise heart rate (HR) and SBP responses.¹⁶ HR recovery after a 6MWT serves as a powerful prognostic indicator in heart failure patients with reduced and preserved ejection fraction.¹⁸ Recently, a significant reduction of 6.2 mm Hg in resting SBP was reported in a randomized controlled trial involving 115 cardiac patients who completed 36 and 24 exercise and educational sessions, respectively.¹⁹

An age-related decrease in cardiorespiratory fitness has been reported in the general population.^20,21 Therefore, we hypothesized that age would be inversely related to cardiorespiratory fitness as estimated by the 6MWT in CR patients. Because few data are available regarding changes in 6MWT performance and associated BP responses in men and women following exercise-based CR, the present study examined these variables in age-adjusted cardiac patients before and after a 12-week intervention.

Methods

Participants

We conducted a retrospective chart review of 311 cardiac patients (237 men, 74 women; aged 57.7 ± 13 years), with height 1.67 ± 0.9 m, body weight (BW) 75.3 ± 13.0 kg, and body mass index (BMI) 26.9 ± 3.9 kg/m², enrolled in a university-based CR program in Costa Rica over 9 years (January 2009 to December 2017). Files were reviewed for demographic information, and patients were assessed before (Pre) and after (Post) the 12-week CR program on the 6MWT, with specific reference to the following variables: resting HR, SBP, resting DBP, post-6MWT HR, post-6MWT recovery HR, and post-6MWT BPs. The study was conducted according to the principles of the Declaration of Helsinki, Fortaleza, 2013. Participation was voluntary, and the experimental procedures, risks, and benefits were explained to each patient. Patients signed an informed consent form before undergoing field testing (6MWT) and the exercise-based CR intervention.

Instruments and Procedures

CR Program Design and Exercise Protocol

All exercise training sessions were conducted in a traditional 12-week outpatient CR program and were monitored with continuous electrocardiographic (ECG) telemetry (Quinton Q-Tel RMS, Cardiac Science, Bothell, WA) and supervised by a family physician and an exercise specialist. The prescribed exercise duration was 20 to 45 minutes per session, with weekly increments of 5 minutes until a total duration of 45 minutes was achieved. The CR program was offered 3 times per week at an intensity of 40% to 80% of VO₂ reserve using a treadmill (Quinton Medtrack CR-60, Cardiac Science, Bothell, WA) and a cycle ergometer (Monark 828E, Monark Exercise AB, Vansbro, Sweden). Exercise intensity was adjusted using the HR reserve method, Borg rating of perceived exertion scale (11-13), or the resting HR (+20 to 30 beats per minute) in patients taking β-blockers. In addition, patients participated in a lifestyle management education class once per week. Educational topics included the following: CVD management, medications, a cardioprotective diet, stress management, and recommendations regarding the progression of physical activity.

6MWT and Hemodynamic Responses

Patients performed the 6MWT according to a standardized protocol as previously described.²² Resting HR, SBP, DBP, and an ECG rhythm strip were obtained before each test at baseline (Pre) and following the 12-week CR program (Post). Accordingly, patients were instructed to remain comfortably seated for 5 minutes before measurements of HR and BP were obtained, without crossing their legs, back fully-supported in the chair and left arm at the heart level. BP was measured using a sphygmomanometer (Welch Allyn, MI) with an appropriate cuff size for each patient. Subsequently, patients walked in a 10-m outdoor hallway for 6 minutes with the goal of covering as much distance as possible. HR, SBP, and DBP responses to exercise were measured immediately after and 5 minutes following completion of the 6MWT.

Statistical Analysis

All data were analyzed using an IBM SPSS statistical package, version 24.0. Descriptive statistics are presented as means and SDs. The 2 by 2 (Gender × Measurement) analysis of covariance (ANCOVA) using age as a covariate was computed to determine differences in selected variables (BW, BMI, resting HR, SBP, DBP, 6MWT distance, and post-6MWT HR, BP, and recovery hemodynamic responses). Pretest to posttest measurement changes (Δ%) and effect sizes (ESs) were also computed. Age quartiles were defined by the following age distribution: Q₁ (≤49.9 years), Q₂ (50 to 59.9 years), Q₃ (60 to 66.9 years), and Q₄ (≥67 years). Pearson correlations were computed between the number of sessions completed and changes in hemodynamic variables. Statistical significance was set a priori at P ≤.05.

Results

Baseline characteristics of the cardiac patient population (n = 311) are presented in Table 1. Overall, patients improved their 6MWT distance by 29.8% (P < .001; ES = 1.25), reduced their resting SBP by 3.6% (P < .001; ES = 0.23), and decreased the corresponding DBP by 3.0% (P < .001; ES = 0.20) following the 12-week CR program. No significant changes were observed for BW, BMI, and resting HR. Significant between-gender changes were observed only for SBP following the 6MWT. Significant within-gender changes were observed on the 6MWT, post-6MWT HR, SBP, and DBP in both men and women, and post-6MWT SBP and recovery HR only in men (Table 2 and Figure 1).

Table 1.

Baseline Characteristics of the Cardiac Patients, by Gender.^a

Variables	Cohort (n = 311)	Males (n = 237)	Females (n = 74)
Age (years)	57.7 ± 13.0	58 ± 13.0	57.8 ± 15.0
Height (m)	1.67 ± 0.9	1.70 ± 0.7	1.56 ± 0.7
Weight (kg)	75.3 ± 13.0	78.3 ± 12.4	65.9 ± 10.9
BMI (kg/m²)	26.9 ± 3.9	26.9 ± 3.6	27.0 ± 4.6
Resting HR (beats/min)	70.0 ± 13.0	69.3 ± 13.0	70.6 ± 12.8
Resting SBP (mm Hg)	109.7 ± 16.8	108.4 ± 16.2	114.4 ± 18.6
Resting DBP (mm Hg)	67.6 ± 10.1	67.2 ± 9.8	69.2 ± 10.7
6MWT (m)	416.4 ± 99.0	429.3 ± 94.6	374.9 ± 100.7
Completed sessions	33.0 ± 5.4	33.1 ± 5.2	32.8 ± 6.1

Abbreviations: BMI, body mass index; HR, heart rate; SBP, systolic blood pressure; DBP, diastolic blood pressure; 6MWT, 6-Minute Walk Test.

Values are mean ± SD.

Table 2.

Outcome Differences Between the Patients by Gender Before and After the CR Program (n = 311).^a

Variables	Men (n = 237)				Women (n = 74)
Variables	Before	After	Δ%	P ≤ within-men	Before	After	Δ%	P ≤ within-women	P ≤ between-gender
Weight (kg)	78.3 ± 12.4	78.1 ± 14.0	−0.26	.754	65.9 ± 10.9	66.6 ± 11.5	1.06	.382	.361
BMI (kg/m²)	26.9 ± 3.7	26.9 ± 4.3	0.00	.831	27.0 ± 4.6	27.3 ± 4.7	1.11	.191	.299
Resting HR (bpm)	69.3 ± 13.0	68.1 ± 10.4	−1.73	.092	70.6 ± 12.8	70.5 ± 11.8	−0.14	.974	.427
Post-6MWT HR (bpm)	97.7 ± 16.8	112.7 ± 21.3	15.35	.000	100.7 ± 20.8	110.2 ± 22.0	9.43	.000	.035
Recovery HR (bpm)	73.9 ± 13.8	75.7 ± 13.2	2.85	.656	74.7 ± 14.2	76.4 ± 13.8	2.41	.653	.988
Resting SBP (mm Hg)	108.4 ± 16.2	105.3 ± 14.5	−2.86	.007	114.4 ± 18.6	107.5 ± 16.2	−5.87	.000	.061
Post-6MWT SBP (mm Hg)	122.8 ± 18.5	133.6 ± 20.7	8.79	.000	127.7 ± 21.3	130.5 ± 17.6	2.27	.185	.002
Resting DBP (mm Hg)	67.2 ± 9.8	65.6 ± 8.5	−2.38	.034	69.2 ± 10.7	65.0 ± 8.0	−6.07	.001	.044
Post-6MWT DBP (mm Hg)	69.7 ± 9.8	70.3 ± 9.5	0.86	.460	71.0 ± 11.0	69.6 ± 8.8	−1.97	.303	.208
6MWT (m)	429.3 ± 94.6	557.6 ± 90.7	29.89	.000	374.9 ± 100.7	483.2± 82.9	28.89	.000	.038

Abbreviations: BMI, body mass index; HR, heart rate; bpm, beats per minute; 6MWT, 6-Minute Walk Test; post-6MWT HR, HR immediately after 6MWT; recovery HR, 5-minute HR recovery after 6MWT; SBP, systolic blood pressure; Post-6MWT SBP, systolic blood pressure immediately after 6MWT; DBP, diastolic blood pressure; Post-6MWT DBP, diastolic blood pressure immediately after 6MWT.

Values are mean ± SD; Δ% refers to relative change.

Figure 1.

Relative change (Δ%) in physical and outcome variables following a cardiac rehabilitation program.

Significant correlations were found in the youngest male cohort (Q₁) between CR sessions completed and ΔDBP (r = −0.33; P = .013), in Q₂ for Δpost-6MWT HR (r = 0.41; P = .001) and Δ recovery HR (r = 0.29; P = .030), and in Q₄ for Δrecovery HR (r = −0.31; P = .016) but not for men in Q₃. For women in Q₄, significant correlations were found between CR sessions and ΔDBP (r = 0.47; P = .040) and Δpost-6MWT SBP (r = 0.51; P = .022). No significant correlations were found between CR sessions on Q₁, Q₂, and Q₃ for 6MWT on any hemodynamic variable.

Discussion

The present study examined changes in 6MWT distance and associated resting and exercise BP responses following a 12-week exercise-based CR program in men and women. These findings are consistent with previous reports relative to improvements in standardized walk performance testing after CR.^6-8 Ghashghaei et al⁸ reported a 19.0% increase in walking distance in patients after coronary artery bypass graft surgery following 2 months of CR. Similarly, Gupta et al⁷ reported a 19.1% improvement in walking distance in cardiac patients after 24 to 36 CR sessions. Other studies have found that cardiac patients improve their walking distance by 21.6% and 31% following CR.^6,16 In the present study, cardiac patients improved their walking distance by 29.8% after 33.0 ± 5.1 CR sessions. Men and women improved their walking distance by 29.9% and 28.9% after CR, respectively. The relative improvements between genders were not statistically significant, substantiating a previous report.¹² In contrast, after adjusting for potential confounders, including age, race, and baseline demographic data, Gupta et al⁷ found that men demonstrated significantly greater relative improvements in walk performance testing than women (20.7% vs 16.8%, respectively) following CR. Gender differences in walk performance testing following CR in previous studies may be explained, at least in part, by the total number of exercise sessions performed by the patients. Gee et al¹⁰ reported that women had a lower CR completion rate than men: 73% versus 65.6% for men and women, respectively. In the present study, men and women completed a comparable number of sessions (n = 33). Another possible explanation regarding the gender differences in physiological outcomes is that for several reasons, including lower education level, multiple comorbid conditions, non-English native language, lack of social support, and a higher burden of family responsibilities, women are less likely to enroll in and complete CR than men.^23-26

In the present study, although the post-CR increment in walking speed—1.3 km/h (0.8 mph) for men versus 1.1 km/h (0.7 mph) for women—did not reach statistical significance, it may have clinical significance. Kavanagh et al⁹ found that a 1.6 km/h (1-mph) increase in walking speed was associated with a 20% decrease in cardiovascular mortality in men with coronary disease. Each 1-MET increase in functional capacity in men appears to confer a 12% improvement in survival²⁷ and a 17% decrease in mortality in women.²⁸ Although the present study did not estimate or directly measure functional capacity, expressed as METs, based on mathematical calculations of walking speed, men walked at 4.3 km/h (2.7 mph) and women at 3.7 km/h (2.3 mph) on initiating CR, which approximated 2.8 to 3.2 METs. Following the CR program, men walked at 5.6 km/h (3.5 mph) and women walked at 4.8 km/h (3.0 mph), corresponding to energy expenditures of 3.3 to 3.7 METs, representing increases of 0.6 and 0.5 METs for men and women, respectively. Middle-aged and older adults who are able to achieve these post-CR walking paces, that is, 3.3 to 3.7 METs, likely have a functional capacity >5 METs, a fitness level compatible with a lower-risk patient subset.¹⁵

In the present study, 3.6% and 3.0% decreases were observed in resting SBP and DBP, respectively. This finding is consistent with previous studies reporting reductions between 2.9% and 11% following CR.^6-8,16,17 A previous report found that cardiac patients reduced resting SBP by 3.6% and DBP by between 2.9% and 5.6% following 3 months of CR.¹⁶ A randomized controlled trial of 118 patients who underwent coronary angioplasty reported average relative reductions in resting SBP of 4.7% after 6 months of CR.¹⁷ Another study found even larger reductions in resting SBP and DBP—11% and 9%, respectively—in patients who had undergone coronary artery bypass graft surgery followed by 2 months of CR.⁸ Reductions in resting SBP and DBP in cardiac patients after exercise training may be a result of reduced total peripheral resistance, increased vasodilation mediated by enhanced endothelial nitric oxide production, or both.²⁹

Recovery HRs after the 6MWT in men and women completing the CR program were 37 and 34 beats/min lower than those obtained following the initial evaluation, consistent with previous reports in cardiac and heart failure patients.¹⁸ Importantly, an impaired recovery HR after a 6MWT is a strong prognostic indicator of future cardiac events and heightened cardiovascular mortality in heart failure patients.¹⁸ Exercise training has been shown to improve cardiovascular responses via adaptations to the autonoemic nervous system, specifically decreased sympathetic and increased parasympathetic activity, likely reducing recovery HR.^4,30 In the present study, only SBP following the 6MWT was significantly different between men and women.

Limitations

We acknowledge some methodological study limitations. First, we reviewed data retrospectively from a single CR program in a university-based setting in Costa Rica. Second, we assessed exercise performance based on the 6MWT and did not estimate or directly measure cardiorespiratory fitness or aerobic capacity, specifically the VO_2max, expressed as METs. Third, we only included participants with 6MWT and hemodynamic evaluations at baseline and following the 12-week CR program. Fourth, it is possible that changes in cardiac medications during CR may have influenced hemodynamic responses in a small number of patients. Finally, the follow-up was limited to 12 weeks. Despite these limitations, the present results, based on one of the largest populations of cardiac patients reported to date (n = 311), have significant clinical implications regarding the benefits of exercise-based CR.

Conclusion

In outpatients with stable CAD, the 6MWT provides independent and additive information beyond traditional risk factors and a prognostic ability similar to treadmill exercise capacity, expressed as peak METs, for predicting future cardiovascular events, including heart failure, MI, and death.³¹ The present findings confirm and extend previous studies, highlighting the relative improvement in 6MWT performance following CR, demonstrating comparable exercise trainability in adherent men and women, and uniquely providing comparative resting and exercise hemodynamic responses to the 6MWT before and after CR. The only gender difference observed was the SBP response following the 6MWT, where men showed greater relative increases than women.

Footnotes

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding

The author(s) received no financial support for the research, authorship, and/or publication of this article.

Ethical Approval

The study was conducted according to the principles of the Declaration of Helsinki, Fortaleza, 2013.

Informed Consent

Patients signed an informed consent form before undergoing field testing and the exercise-based CR intervention.

Trial Registration

Not applicable, because this article does not contain any clinical trials.

ORCID iD

Felipe Araya-Ramírez

References

Ministerio de Salud. Memoria Institucional 2010-2014. Published May 2014. Accessed January 29, 2021. https://www.ministeriodesalud.go.cr/sobre_ministerio/memorias/memoria2014/UMI_memoria_institucional_2010_2014.pdf

Lavie

Milani

RV.

Effects of cardiac rehabilitation programs on exercise capacity, coronary risk factors, behavioral characteristics, and quality of life in a large elderly cohort. Am J Cardiol. 1995;76:177-179.

Taylor

Brown

Ebrahim

, et al. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 2004;116:682-692.

Williams

Ades

Hamm

, et al. Clinical evidence for a health benefit from cardiac rehabilitation: an update. Am Heart J. 2006;152:835-841.

Anderson

Oldridge

Thompson

, et al. Exercise-based cardiac rehabilitation for coronary heart disease: Cochrane Systematic Review and Meta-Analysis. J Am Coll Cardiol. 2016;67:1-12.

Araya-Ramírez

Briggs

Bishop

Miller

Moncada-Jiménez

Grandjean

PW.

Who is likely to benefit from phase II cardiac rehabilitation?

J Cardiopulm Rehabil Prev. 2010;30:93-100.

Gupta

Sanderson

Bittner

Outcomes at one-year follow-up of women and men with coronary artery disease discharged from cardiac rehabilitation: what benefits are maintained?

J Cardiopulm Rehabil Prev. 2007;27:11-18.

Ghashghaei

Sadeghi

Marandi

Ghashghaei

SE.

Exercise-based cardiac rehabilitation improves hemodynamic responses after coronary artery bypass graft surgery. ARYA Atherosclerosis. 2012;7:151-156.

Kavanagh

Hamm

Beyene

, et al. Usefulness of improvement in walking distance versus peak oxygen uptake in predicting prognosis after myocardial infarction and/or coronary artery bypass grafting in men. Am J Cardiol. 2008;101:1423-1427.

10.

Gee

Viera

Miller

Tolleson-Rinehart

Functional capacity in men and women following cardiac rehabilitation. J Cardiopulm Rehabil Prev. 2014;34:255-262.

11.

Lavie

Milani

RV.

Effects of cardiac rehabilitation and exercise training on exercise capacity, coronary risk factors, behavioral characteristics, and quality of life in women. Am J Cardiol. 1995;75:340-343.

12.

O’Farrell

Murray

Huston

LeGrand

Adamo

Sex differences in cardiac rehabilitation. Can J Cardiol. 2000;16:319-325.

13.

Guyatt

Sullivan

Thompson

, et al. The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. Can Med Assoc J. 1985;132:919-923.

14.

Yazdanyar

Aziz

Enright

, et al. Association between six minute walk test and all-cause mortality, coronary heart disease-specific mortality, and incident coronary heart disease. J Aging Health. 2014;26:583-599.

15.

Franklin

Brinks

Sacks

Trivax

Friedman

Reduced walking speed and distance as harbingers of the approaching grim reaper. Am J Cardiol. 2015;116:313-317.

16.

Araya-Ramírez

Ureña-Bonilla

Blanco-Romero

Grandjean

PW.

Efecto de un programa de ejercicios en la capacidad funcional y respuesta hemodinámica de pacientes con enfermedad cardiovascular. Rev Costarricense de Cardiología. 2014;16:5-11.

17.

Belardinelli

Paolini

Cianci

Piva

Georgiou

Purcaro

Exercise training intervention after coronary angioplasty: the ETICA Trial. J Am Coll Cardiol. 2001;37:1891-1900.

18.

Cahalin

Arena

Labate

Bandera

Lavie

Guazzi

Heart rate recovery after the 6 min walk test rather than distance ambulated is a powerful prognostic indicator in heart failure with reduced and preserved ejection fraction: a comparison with cardiopulmonary exercise testing. Eur J Heart Failure. 2013;15:519-527.

19.

Chaves

GSDS

Ghisi

GLM

Grace

Ribeiro

Britto

. Effects of comprehensive cardiac rehabilitation on functional capacity in a middle-income country: a randomised controlled trial. Heart. 2019;105:406-413.

20.

Kaminsky

Arena

Myers

Reference standards for cardiorespiratory fitness measured with cardiopulmonary exercise testing: data from the Fitness Registry and the Importance of Exercise National Database. Mayo Clin Proc. 2015;90:1515-1523.

21.

Mandsager

Harb

Cremer

Phelan

Nissen

Jaber

Association of cardiorespiratory fitness with long-term mortality among adults undergoing exercise treadmill testing. JAMA Netw Open. 2018;1:e183605.

22.

Steele

Timed walking tests of exercise capacity in chronic cardiopulmonary illness. J Cardiopulm Rehabil. 1994;16:25-33.

23.

Feola

Garnero

Daniele

, et al. Gender differences in the efficacy of cardiovascular rehabilitation in patients after cardiac surgery procedures. J Geriatr Cardiol. 2015;12:575-579.

24.

Thomas

Miller

Lamendola

, et al. National survey on gender differences in cardiac rehabilitation programs: patient characteristics and enrollment patterns. J Cardiopulm Rehabil. 1996;16:402-412.

25.

Caulin-Glaser

Blum

Schmeizl

Prigerson

Zaret

Mazure

CM.

Gender differences in referral to cardiac rehabilitation programs after revascularization. J Cardiopulm Rehabil. 2001;21:24-30.

26.

Supervía

Medina-Inojosa

Yeung

, et al. Cardiac rehabilitation for women: a systematic review of barriers and solutions. Mayo Clin Proc. 2017;92:565-577.

27.

Myers

Prakash

Froelicher

Partington

Atwood

JE.

Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793-801.

28.

Gulati

Pandey

Arnsdorf

, et al. Exercise capacity and the risks of death in women: the St. James Women Take Heart Project. Circulation. 2003;108:1554-1559.

29.

Hambrecht

Adams

Erbs

, et al. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation. 2003;107:3152-3158.

30.

Tabeta

Meurina

Driss

, et al. Benefits of exercise training in chronic heart failure. Arch Cardiovasc Dis. 2009;102:721-730.

31.

Beatty

Schiller

Whooley

MA.

Six-minute walk test as a prognostic tool in stable coronary heart disease: data from the Heart and Soul Study. Arch Intern Med. 2012;172:1096-1102.

Improved Walk Test Performance and Blood Pressure Responses in Men and Women Completing Cardiac Rehabilitation: Implications Regarding Exercise Trainability

Abstract

Keywords

Introduction

Methods

Participants

Instruments and Procedures

CR Program Design and Exercise Protocol

6MWT and Hemodynamic Responses

Statistical Analysis

Results

Discussion

Limitations

Conclusion

Footnotes

Declaration of Conflicting Interests

Funding

Ethical Approval

Informed Consent

Trial Registration

ORCID iD

References