Abstract
Thank you very much for reading this article carefully and for your valuable comments. I will answer objectively and scientifically explain some of your comments.
First of all, you mentioned that in this study, you must record the aortic reset time, the type of heart surgery, the extracorporeal circulation time and the vasoactive drugs used before and during the operation. I agree and accept your suggestions with an open mind.
In this study, aortic insertion time and cardiopulmonary bypass time were recorded, and the results showed no correlation between the changes, but they were not reflected in this article. We have not collected data about the use of vasoactive drugs before and during surgery. In follow-up related research, we will follow your suggestions and reflect these data records and analysis in the article. Because of the limited type and quantity of local cardiac surgery, the types of cardiac surgery are not detailed, which will affect the objective analysis of related parameters.
Second, the doses of midazolam and propofol you mentioned are 1-2 mg/kg and 4-6 mg/kg/h. We accept your suggestion and it will be reflected in the article in the follow-up further research.
Thirdly, regarding the implantation flow rate of cardiopulmonary bypass, we mainly use shallow hypothermia during the operation, the flow rate is 2.2-2.4 L/min.m2, and the flow rate is reduced by 7% for every degree of body temperature drop. In the subsequent further research on dexmedetomidine, we will reorganize the data as the collection object for recording and analysis.
Fourth, the blood dilution you mentioned, we maintain it at around 80g/L for adults during the operation, and maintain it at 9-10 g/L after stopping extracorporeal circulation for modified ultrafiltration. But we did not collect relevant data. This is where we need to further improve and improve.
Fifth, the application research on different doses of dexmedetomidine is the direction of our further research.
Thanks again for your attention and pertinent opinions. We will continue to study and improve the experimental design in further research, and present our research results more objectively.
