Objective: To clarify key concepts in the administration and interpretation of grip strength assessment across the continuum of care through a scoping review, and report the evidence that addresses and informs practice. Methods: Electronic databases, Medline and CINAHL (Cumulative Index to Nursing and Allied Health Literature), were searched from 2011 to 2016 for abstracts that included 1 or more of the following terms: hand strength, grip strength, sincerity of effort, and muscle dynamometry. Studies were selected using an iterative team approach and were included if they were published in English, used either hydraulic or digital instruments with established validity and reliability to assess grip strength, and reported the method of assessment, the population tested, and the practice context. Implications for rehabilitation practice across the continuum of care were identified by the authors and validated through a consultation process with clinicians in various practice areas (medicolegal, acute care, geriatrics, and hand rehabilitation). Results: Updated information regarding assessment protocol, norms, and the impact of age, gender, nutritional status, and vocational and avocational activities will be presented. Use of grip strength in the determination of sincerity of effort testing will be challenged in light of the findings. In addition, the prognostic value of grip strength assessment for all-cause mortality, cardiovascular death, cardiovascular mortality, and acute hospital admission length of stay will be highlighted. Conclusions: Evidence-based administration and interpretation of grip strength assessment by rehabilitation professionals are essential components of comprehensive assessment across the continuum of care. The finding of this scoping review supports the formal assessment of grip strength in multiple practice environments and highlights its prognostic value.