Objective: The objective of the study was to present an alternative therapeutic option that could replace local skin flaps in the management of fingertip amputations and to report the results from a functional, aesthetic, and general satisfaction point of view. Method: Descriptive study in adult population which included patients with fingertip amputations treated with semi-occlusive dressing consisting of a polyurethane adhesive. The injuries were classified according to the Allen classification. All lesions received a 3 liters of saline solution wash, debridement, administration of single dose of prophylactic antibiotic, tetanus vaccination by hospital policy, and application of a semiocclusive dressing under transient ischemia of the affected finger. There was no intervention in the exposed bone even though its exposition might be located at the level of amputation or beyond. At the time of discharge, all cases were studied with radiograph and ultrasound, measuring the thickness of soft tissue distal to the bone level. The 400 Points Test and QuickDASH, validated for the Chilean population, were applied 1 month after discharge. All patients were presented with the option of psychological check. For the data analysis, Stata 12.1 was used. Results: A total of 67 injuries were obtained. The average age of treated patients was 43 years old (SD = 14.7). According to Allen’s classification, lesions were: level 1 35.82%, level 2 37.31%, level 3 25.37%, and level 4 1.49%. All cases achieved full healing in the injured finger. The mean time of disability was 60.58 days (SD = 16.66). The length of soft tissue growth distal to the bone level as measured by ultrasound had an average of 3.66 mm (SD = 0.72). All patients achieved full functional and aesthetic satisfaction, with a median for 400 Points and QuickDASH Test of 90 and 12.6, respectively. There were no complications such as infection, scarring, neuroma, or osteitis. No supplementary flap or additional therapeutic action was required. Conclusions: Semi-occlusive dressing for the treatment of fingertip amputations is a valid option for obtaining satisfactory results from a functional, aesthetic, and global point of view. It is a very easy method to execute in emergency rooms and has a very low cost and a high reproducibility. No complications have been recorded, and it is an excellent alternative to local skin flaps. However, we believe that future studies that incorporate more complex methodological designs should be made to be able to present a greater external validity.