Factor VII has been utilized to treat post-operative bleeding after cardiac surgery refractory to other intervention. We report the case of a patient who developed intractable bleeding after a severe protamine reaction following emergency repair of type A aortic dissection and was successfully treated with factor VII.
LauritzenB., HednerU., JohansenP.B.Recombinant human factor VIIa and a factor VIIa-analogue reduces heparin and low molecular weight heparin (LMWH)-induced bleeding in rats. J Thromb Haemost.2008; 6: 804–811.
2.
CollinsC., O'DonnellA.Does an allergy to fish pre-empt an adverse protamine reaction? A case report and a literature review. Perfusion.2008; 23: 369–372.
3.
WahedS., KaragounisA.P., NiranjanG., KanagasabayR.Successful graft patency after factor VIIa use for bleeding in coronary artery surgery: an unusual complication of a coronary artery bypass surgery. J Card Surg.2007; 22: 424–427.
