Restricted accessReview articleFirst published online 2026
Meta-Analysis of the Efficacy of Ultrasound-Guided Mammotome Minimally Invasive Surgery and Traditional Open Surgery in the Therapy of Benign Breast Tumors
To systematically analyze the efficacy of ultrasound-guided mammotome minimally invasive surgery and traditional open surgery in the therapy of benign breast tumors.
Methods
A computerized search retrieved original literature on the therapeutic effects of ultrasound-guided mammotome minimally invasive surgery and traditional open surgery for benign breast tumors from authoritative databases, including CNKI, Wanfang, VIP, Web of Science, PubMed, ScienceDirect, Cochrane Library, and Embase. The search covered from database inception to January 2024, using a strategy of subject terms combined with free terms. The retrieved literature was screened, data were extracted, and quality was evaluated. Meta-analysis was performed using RevMan 5.4 software.
Results
A total of 8 literatures were included in the study, and a total of 1909 patients with benign breast tumors were found from 2018 to 2023. The results of meta-analysis showed that the operation time [MD = −12.79, 95%CI (−14.04, −11.55), P < 0.00001], intraoperative blood loss [MD = −11.55, 95%CI (−14.74, −8.36), P < 0.00001], healing time [MD = −2.73, 95%CI (−4.03, −1.43), P < 0.00001] and complication rate [MD = 0.17, 95%CI (0.12, 0.26), P < 0.00001] was apparently different from traditional open surgery (P < 0.05).
Conclusion
Ultrasound-guided mammotome minimally invasive surgery can effectively shorten the operation time of patients with benign breast tumors, reduce intraoperative blood loss, promote healing, and reduce the risk of complications. The effect is better than that of traditional open surgery.
BagulSShaikhJMDasSJadhavRV. Clinical spectrum study of female patients with benign breast diseases in surgery department of tertiary care centre. Int Surg J. 2024;11(3):392-397. doi:10.18203/2349-2902.isj20240571.
2.
KumarN. Breast fibroadenoma and its clinical perspectives: a prospective observational study. International Surgery Journal. 2021;8(7):2129.
3.
WeiMDuYWuXZhuJ. Automatic classification of benign and malignant breast tumors in ultrasound image with texture and morphological features. IEEE. 2019.
4.
TurkyilmazZSarisikEOzkurtE, et al.Evaluation of benign breast diseases with or without atypical epithelial hyperplasia accompanying radial scars. European Journal of Breast Health. 2023;19(2):166-171.
5.
SaimuraMKogaKAnanKMitsuyamaSTamiyaS. Diagnosis, characteristics, and treatment of breast carcinomas within benign fibroepithelial tumors. Breast Cancer. 2018.
6.
El-ZoghbyAWakimHRAhmedDAmerAAbdel-AzizARA. A Comparative Study Assessing Surgical Outcome of Excision of Giant or Multiple Benign Breast Lesions Using Circumareolar Incision Versus Round Block Technique. The Clinical Society of Cairo University; 2021.
7.
LeeHYChangYWYuDY, et al.Comparison of single incision endoscopic nipple-sparing mastectomy and conventional nipple-sparing mastectomy for breast cancer based on initial experience. Journal of Breast Cancer. 2021;24:196-205.
8.
LiRLiJChenSXiaoBLiuLZhuN. Comparison of curative complications between mammotome-assisted minimally invasive resection and conventional open resection for breast neoplasm. In: A Retrospective Clinical Study. Hindawi Limited; 2021.
9.
FarooqiNBNaseerSAtariHAHBalouchVMuzaffar Ali JoyoR. Excision of fibroadenoma with an upper incision compared to the periareolar incision. PJMHS. 2022;16(3):1169-1170. doi:10.53350/pjmhs221631169.
10.
LiuMZhouXGaoL, et al.Considerable long-term aesthetic outcomes and oncologic safety of breast-conserving surgery via a periareolar incision: a retrospective study. Clin Breast Cancer. 2023;23(8):e549-e559.e4.
11.
WangHWangQZhangYPengY. Value of ultrasound BIRADS classification in preoperative evaluation of the ultrasoundguided Mammotomeassisted minimally invasive resection of breast masses: a retrospective analysis. Exp Ther Med. 2023;25:143.
12.
WooJLeeJPaekSHLimW. Feasibility and safety of breast-conserving surgery via a periareolar incision for cancers located far from the nipple–areolar complex: a retrospective study. J Cancer Res Clin Oncol. 2020;147:1-8.
13.
NicosiaLBozziniAAddanteF, et al.Wireless ultrasound‐guided vacuum‐assisted breast biopsy: experience in clinical practice at European Institute of Oncology. Breast J. 2021;27(6):514-520. doi:10.1111/tbj.14216.
14.
ZhouWLuoHZhaoHPengY. Unexpected breast cancer mimicking benign lesions on ultrasound-guided vacuum-assisted excision biopsy: a retrospective cross-sectional study over a 20-year period. Front Oncol. 2023;13:1108689. doi:10.3389/fonc.2023.1108689.
15.
QuSZhangWZhangJZhangQLuRWangN. The vacuum-assisted breast biopsy system is an effective treatment strategy for breast lumps after augmentation with autologous fat grafting. Aesth Plast Surg. 2019;43(5):1152-1157. doi:10.1007/s00266-019-01433-2.
16.
YooHSKangWSPyoJSYoonJ. Efficacy and safety of vacuum-assisted excision for benign breast mass lesion: a meta-analysis. Medicina. 2021;57(11):1260. doi:10.3390/medicina57111260.
17.
ChangDHShuYL. Clinic efficacy and safety of ultrasound-guided Mammotome-assisted surgery for patients with breast benign tumors. Eur Rev Med Pharmacol Sci. 2023;27(13):5985-5992.
18.
HongFZiweiZHanXYaoY. Clinical curative effect and the immune function influence of Mammotome minimally invasive sur gery on 1 cm benign breast diseases. Journal of Clinical Surgery. 27(3).
19.
HuaZFangQ. Ultrasound-guided mammotome minimally invasive excision versus traditional surgery for treatment of breast masses. Int J Clin Exp Med. 2019;12(8):6.
20.
JiangJGaoJ. Ultrasound-guided minimally invasive mammotomy versus conventional surgery for benign breast tumors. Chin J Prim Med Pharm2021;28(10):1448-1451.
21.
LinM. Clinical efficacy and safety analysis of minimally invasive breast gyrotomy with mammotome in the treatment of benign breast masses. World Latest Medicne Information. 2018;18:99.
22.
MaZZhangB. Comparison of clinical effect, complications, prognosis between minimally invasive surgery and traditional open methods in treating benign breast tumor. Medical Journal of Air Force. 2019;35:5.
23.
WangLShiYQiaoC. Study on the clinical effect of minimally invasive mastectomy with Mammotome in the treatment of breastbenign tumor. Chin J Prim Med Pharm2020;27(18):2201-2205.
24.
WangQZhengJRenYXuH. Clinical effect of trans-areolar resection and minimally invasive mammotome biopsy in the treatment of breast fibroadenoma and its impact on the quality of life of patients. Am J Transl Res. 2022;14(5):3539-3546.
25.
LuYChenYZhuLCartwrightPChenKJacobsL. Local recurrence of benign, borderline, and malignant phyllodes tumors of the breast: a systematic review and meta-analysis. Ann Surg Oncol. 2019;26(5):1263-1275.
26.
LiangMZhangCXiaT, et al.Ultrasound radiomics features predicting the dosimetry for focused ultrasound surgery of benign breast tumor: a retrospective study. Front Genet. 2022;13:969409. doi:10.3389/fgene.2022.969409.
27.
ZhuGWuN. Clinical experience of small incision-assisted encor system in resection of large breast tumors. Clin Oncol. 2022;6(11):1-6.
28.
WangBJiangYZhangMK, et al.Efficacy and safety of percutaneous ultrasound—guided vacuum—assisted excision for the treatment of clinical benign breast lesions larger than 3 cm: a retrospective cohort study. Ann Transl Med. 2022;10(24):1345. doi:10.21037/atm-22-5829.
29.
TourasseCKhasanovaESebagPBeregiJP. Ultrasound-guided vacuum-assisted breast biopsy with a small-caliber device: a multicenter consecutive study of 162 biopsied lesions. Tumori. 2019;105(4):312-318. doi:10.1177/0300891618784786.
30.
ZhaocaiYINZhenyuMEIShengY, et al.Comparison the efficacy of minimally invasive surgery and traditional surgery in the treatment of multiple benign mammary lumps. Int J Surg. 2019;12:329-333.
ZhengQCaiZLiMZhangYRuRYaoC. Therapeutic effect of ultrasound-guided rotary cutting on benign breast tumors and factors related to postoperative hematoma. Int J Clin Exp Med. 2018.
33.
HuWZhangFQinpingJShenY. Ultrasound-guided vacuum-assisted breast biopsy system for diagnosis and minimally invasive excision of intraductal papilloma without nipple discharge. World J Surg. 2009.
34.
WuZLiP. Comparison of the clinical efficacy of mammotome minimally invasive biopsy and conventional breast tumor resection for benign breast tumor. Chinese Journal of Primary Medicine and Pharmacy2017;24(7):1000-1003.
35.
ChenCLuoLGaoD, et al.Surgical drainage of lactational breast abscess with ultrasound-guided Encor vacuum-assisted breast biopsy system. Breast J. 2019;25(5):889-897.
36.
GaoYGeZWangZZhangHYangZ. Ultrasound-guided vacuum-assisted breast complete duct excision: a novel mini-mally invasive surgical technique for pathological nipple discharge. J Surg. 2023;3(2):1131.
37.
WangYWangJLiuL, et al.Comparison of curative effects between mammotome‐assisted minimally invasive resection (MAMIR) and traditional open surgery for gynecomastia in Chinese patients: a prospective clinical study. Breast J. 2019;25(6):1084-1089. doi:10.1111/tbj.13424.
38.
ZouSFTaoLFengZC, et al.A comparative study on ultrasound-guided elite, Mammotome, and core needle biopsy for diagnosing malignant breast masses. Arch Med Sci. 2019;18:422-431. doi:10.5114/aoms.2019.87096.
