This study aims to systematically analyze the global research landscape of polymeric materials in surgical applications, identifying core themes, technological trends, and clinical translation potential over the past decade.
Methods
A bibliometric analysis was conducted using the Web of Science Core Collection (2016-2025). A targeted search strategy combining polymer-related, surgery-related, and functional biomedical keywords was applied. Data were analyzed using the Bibliometrix R package and VOSviewer to explore publication trends, international collaborations, keyword co-occurrence, and citation networks. Key studies were manually reviewed to interpret their technological contributions.
Results
A total of 4668 original articles were retrieved, showing a 15.8% annual growth. China led global output (49.9%), followed by the USA. Keyword clustering revealed four major themes: nanoparticle-based drug delivery, biological responses and angiogenesis, clinical surgical applications (eg, hemostasis, adhesion), and multifunctional hydrogels. Research hotspots included antibacterial, adhesive, and hemostatic materials. Highly cited studies focused on injectable, self-healing, and bioactive hydrogels for complex wound repair and organ-specific applications.
Conclusion
The field of surgical polymeric materials is rapidly advancing toward multifunctional, minimally invasive, and responsive systems. This bibliometric study provides a data-driven knowledge map to guide future research and promote clinical translation, helping bridge the gap between material innovation and surgical application. Future research should also focus on optimizing the scalability and cost-effectiveness of these technologies while addressing regulatory and safety challenges. Large-scale clinical trials and interdisciplinary education help bridge the gap between materials science and clinical implementation.
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