Primary (Idiopathic) Generalized Epilepsy and Underlying Mechanisms

Delgado-Escueta AV Ward AA Jr Woodbury DM Porter RJ . New wave of research in the epilepsies. In: Delgado AV Ward AA Jr Woodbury DM Porter RJ (eds). Basic Mechanisms of the Epilepsies, New York: Raven Press; 1986: 3–55,.

Schwartzkroin P . Basic mechanisms of epileptogenesis. In: Wyllie E (ed). The Treatment of Epilepsy. Philadelphia: Lea and Febiger; 1993: 83–98.

Meldrum BS . Neurotransmission in epilepsy. Epilepsia 1995; 36(Suppl); S30–S35.

Penfield W . The cerebral cortex in man. I. Cerebral cortex and consciousness. Arch Neurol Psychiat 1938; 40: 417–442.

Penfield W . Epileptic automatism and centrencephalic integrating system. Publ Assoc Res Nerv Ment Dis 1952; 30: 513–528.

Penfield W Jasper HH . Epilepsy and the Functional Anatomy of the Human Brain. Boston: Little, Brown and Co.; 1954.

van der Kolk Schroder JLC . London: Sydenham Society; 1859. Quoted after Muskens LJJ. Epilepsy — Comparative Pathogenesis, Symptoms, Treatment. London: Tindall and Cox; 1928.

Nothnagel H . Die Entsehung allgemeiner Convulsionen vom Pons und der Medulla oblongata aus. Virchows Arch Path Anat 1868; 44: 1–12.

Killam KF Naquet Bert J . Paroxysmal responses to intermittent light stimulation in a population of baboons (Papio papio). Epilepsia 1966; 7: 215–219.

Killam KF Killam EK Naquet R . An animal model of light sensitive epilepsy. Electroencephalogr Clin Neurophysiol 1967; 22: 497–513.

Naquet R Killam KF Killam EK Bimar J Poncet M . Un nouveau “modèle animal” pour l‘étude de l’épilepsie: Le Papio papio. Actual Neurophysiol (Paris) 1968; 8: 213–230.

Fischer-Williams M Poncet M Riche D Naquet R . Light-induced epilepsy in baboon Papio papio: Cortical and depth recordings. Electroencephalogr Clin Neurophysiol 1968; 25: 557–569.

Naquet R Menini C Catier J . Photically-induced epilepsy in Papio papio. The initiation of the discharges and the role of the frontal cortex and of the corpus callosum. In: Petsche H Brazier MAB (eds). Synchronization of EEG Activity in Epilepsies. Vienna: Springer; 1972: 347–366.

Menini C . Rôle du cortex frontal dans l‘épilepsie photosensible du singe Papio papio. J Physiol (Paris) 1976; 72: 5–44.

Menini C Silva-Comte C Velluti JC Naquet R . Fron-to-rolandic cortex and myoclonus in the photosensitive Papio papio. Electroencephalogr Clin Neurophysiol 1983; 56: 1P (abstract).

Naquet R Valin A . Focal discharges in photosensitive generalized epilepsy. In: Avoli M Gloor P Kostopoulos G Naquet R (eds). Generalized Epilepsy. Boston: Birkhäuser; 1990: 273–285.

Silva-Barrat C Menini C . Photosensitive epilepsy of the baboon; A generalized epilepsy with a motor cortical origin. In: Avoli M Gloor P Kostopoulos G Naquet R (eds): Generalized Epilepsy. Boston: Birkhäuser; 1990: 286–297.

Naquet R . Genetic study of epilepsy. Contributions of different models, especially the photosensitive Papio papio. In: Brazier MAB (ed). Growth and Development of the Brain. New York: Raven Press; 1975: 219–230.

Jasper HH . Historical introduction. In: Avoli M Gloor P Kostopoulos G Naquet R (eds). Generalized Epilepsy. Boston: Birkhäuser; 1990: 1–15.

Jasper HH Droogleever-Fortuyn J . Experimental studies of the functional anatomy of petit mal epilepsy. Publ Assoc Res Nerv Ment Dis 1947; 26: 272–298.

Morison RS Dempsey EW . Study of thalamocortical relations. Amer J Physiol 1942; 135: 281–292.

Ingvar DN . Reproduction of 3 per second spike and wave EEG pattern by subcortical stimulations in cats. Acta Physiol Scand 1955; 33: 137–150.

Pollen DA Perot P Reid KH . Experimental bilateral wave and spike from thalamic stimulation in relation to level of arousal. Electroencephalogr Clin Neurophysiol 1963; 15: 1017–1028.

Pollen DA . Experimental spike and wave responses and petit mal epilepsy. Epilepsia 1968; 9: 221–232.

Pollen DA . Intracellular studies of cortical neurons during thalamic induced wave and spike. Electroencephalogr Clin Neurophysiol 1964; 17: 398–404.

Pollen DA Reid KH Perot P . Micro-electrode studies of experimental wave and spike in the cat. Electroencephalogr Clin Neurophysiol 1964; 17: 57–64.

Weir B . Spikes-wave from stimulation of the reticular core. Arch Neurol 1964; 11: 209–218.

Weir B Sieg PG . Extracellular unit activity in the cat during the spike-wave complex. Epilepsia 1966; 7: 30–43.

Hunter J Jasper HH . Effects of thalamic stimulation in unanaesthetized animals. Electroencephalogr Clin Neurophysiol 1949; 1: 305–324.

Prince DA Farrell D . “Centrencephalic” spike wave discharges following parenteral penicillin injection in the cat. Neurology 1969; 19: 309–310.

Fisher RS Prince DA . Spike-wave rhythms in cat cortex induced by parenteral penicillin. I. Electroencephalographic findings. Electroencephalogr Clin Neurophysiol 1977; 42: 608–624.

Quesney LF Gloor P Kratzenberg E Zumstein H . Pathophysiology of generalized penicillin epilepsy in the cat. The role of cortical and subcortical structures. I. Systemic application of penicillin. Electroencephalogr Clin Neurophysiol 1977; 42: 640–655.

Gloor P Quesney LF Zumstein H . Pathophysiology of generalized penicillin epilepsy in the cat. The role of cortical and subcortical structures. II. Topical application of penicillin to cerebral cortex and subcortical structures. Electroencephalogr Clin Neurophysiol 1977; 43: 79–94.

Gloor P . Evolution of the concept of the mechanisms of generalized epilepsy with spike and wave discharge. In: Wada JA (ed). Modern Perspectives in Epilepsy. St. Albans: Eden Press; 1978: 99–137.

Avoli M Gloor P . The effects of transient functional depression of the thalamus on spindles and on bilateral synchronous epileptic discharges in feline generalized penicillin epilepsy. Epilepsia 1981; 22: 443–452.

Avoli M Gloor P . Thalamic involvement in feline generalized epilepsy: Data from unilaterally and bilaterally decorticated animals. Electroencephalogr Clin Neurophysiol 1982; 54: P39 (abstract).

Kostopoulos G Avoli M Pellegrini A Gloor P . Laminar analysis of spindles and spikes of the spike and wave discharge in feline generalized penicillin epilepsy: EEG features. Exp Neurol 1982; 53: 1–13.

Gloor P . Electrophysiology of generalized epilepsy. In: Schwartzkroin PA Wheal HV (eds). Electrophysiology of Epilepsy. London: Academic Press; 1984: 107–136.

Avoli M Gloor P Kostopoulos G . Focal and generalized epileptiform activity in the cortex: In search of differences in synaptic mechanisms, ionic movements and long-lasting changes in neuronal excitability. In: Avoli M Gloor P Kostopoulos G Naquet R (eds). Generalized Epilepsy. Boston: Birkhäuser; 1990: 213–231.

Gloor P Avoli M Kostopoulos G . Thalamocortical relationships in generalized epilepsy with bilaterally synchronous spike-and-wave discharge. In: Avoli M Gloor P Kostopoulos G Naquet R (eds). Generalized Epilepsy. Boston: Birkhäuser; 1990: 190–212.

Avoli M Gloor P Kostopoulos G Naquet R (eds). Generalized Epilepsy. Boston: Birkhäuser; 1990.

Steriade M . Spindling, incremental thalamocortical responses, and spike-wave epilepsy. In: Avoli M Gloor P Kostopoulos G Naquet R (eds): Generalized Epilepsy. Boston: Birkhäuser; 1990: 161–180.

Steriade M . Cellular Substrates of brain rhythms. In: Niedermeyer E da Silva Lopes F (eds). Electroencephalography, 3rd ed. Baltimore: Williams and Wilkins; 1993: 27–62.

Libouban S Oswaldo-Cruz E . Quelques observations relatives aux activités évoquées et spontanées du cerveau du rat blanc. J Physiol (Paris) 1958; 50: 380–383.

Klingberg F Pickenhain L . Auslosung von Spindelaktivitat im Neokortex der Ratte durch Reizung des ventralen Thalamuskerns. Acta Biol Med Germ 1969; 23: 99–110.

Vergnes A Marescaux C Depaulis A Micheletti G Warter JM . Spontaneous spike-and-wave discharges in Wistar rats. A model of genetic generalized nonconvulsive epilepsy. In: Avoli M Gloor P Kostopoulos G Naquet R (eds). Generalized Epilepsy. Boston: Birkhäuser; 1990: 238–253.

Vergnes M Marescaux C Micheletti G Rumbach L Warter JM . Spontaneous paroxysmal electroclinical patterns in rat: A model of generalized non-convulsive epilepsy. Neurosci Lett 1982; 33: 97–101.

Marescaux C Micheletti G Vergnes M Depaulis A Rumbach L Warter JM . A model of chronic spontaneous petit mal-like seizures in the rat. Epilepsia 1984; 25: 326–331.

Mirsky AF Duncan CC Myslobodsky MS . Petit mal epilepsy: A review and integration of recent information. J Clin Neurophysiol 3: 179–208.

Fariello RG Golden GT . The THIP-induced model of bilateral synchronous spike-and-wave in rodents. Neuropharmacology 1987; 26: 383–398.

Snead OC III . Gamma-Hydroxybutyrate model of generalized absence seizures: Further characterization and comparison with other absence models. Epilepsia 1988; 29: 361–368.

Coenen AML Van Luijtelaar ELJM . The WAG/Rij rat model for absence epilepsy: Age and sex factors. Epilepsy Res 1987; 1; 297–301.

Snead OC III . Basic mechanisms of generalized absence seizures. Ann Neurol 1995; 37: 146–157.

Green MC Sidman RL . Tottering — a neuromuscular mutation in the mouse. J Hered 1962; 53: 233–237.

Noebels JL Sidman RL . Inherited epilepsy: Spikewave seizures in the mouse. Science 1979; 202: 1334–1336.

Noebels JL . The developmental neurogenetics of spike-and-wave epilepsy. In: Kellaway P Noebels JL (eds). Problems and Concepts in Developmental Neurophysiology. Baltimore: Johns Hopkins University Press; 1989: 29–44.

Niedermeyer E . The Generalized Epilepsies. Springfield: Thomas, 1972.

Gastaut H Zifkin BG Mariani E Puig JS . The long-term course of primary generalized epilepsy with persisting absences. Neurology 1986; 36: 1021–1028.

Gastaut H Gastaut JL Silva Gonçalves E Sanchez GR . Relative frequency of different types of epilepsy: A study employing the classification of the International League Against Epilepsy. Epilepsia 1975; 16: 457–461.

Delgado-Escueta AV Greenberg DA Treiman L Liu A Sparkles RS Barbetti A Park MS Terasaki Pl . Mapping the gene for juvenile epilepsy. Epilepsia 1989; 30(Suppl 4): S8–S18.

Doose H Gerken H Horstmann T Volzke E . Genetic factors in spike-wave absences. Epilepsia 1973; 14: 57–75.

Doose H Baier WK . Genetic factors in epilepsies with primary generalized minor seizures. Hippokrates 1987; 18(Suppl 1): 1–64.

Palmer FB Yarworth S Niedermeyer E . Frontal midline theta rhythm. Clin Electroencephalogr 1976; 7: 131–138.

Niedermeyer E . Maturation of the EEG: Development of waking and sleep patterns. In: Niedermeyer E da Silva Lopes F (eds). Electroencephallography, 3rd ed. Baltimore: Williams and Wilkins; 1993; 167–191.

Lugaresi E Pazzaglia P Frank L Roger J Paillas Bureau M Ambrosetto G Tassinari CA . Evolution and prognosis of primary generalized epilepsies of the petit mal absence type. In: Gastaut H Pazzaglia P Tassinari CA (eds). Evolution and Prognosis of the Epilepsies. Bologna: Gaggi; 1973: 3–22.

Niedermeyer E . Immediate transition from petit mal absence into a grand mal seizure. Europ Neurol 1976; 14: 11–16.

Passouant P Cadilhac J Labauge R . La localisation électroencéphalographique d'un foyer anatomique au cours du sommeil. Montpellier Méd 1954; 65: 581–598.

Singh B Sehti JM . Electroencephalographic patterns of sleep in epilepsy. Neurology (Bombay) 1957; 5: 34–38.

Singh B . Electroencephalographic study of “bang” response in normal and epileptic individuals. Neurology (Bombay) 1958; 6: 17–19.

Niedermeyer E . Sleep electroencephalograms in petit mal. Arch Neurol 1965; 12: 625–630.

Niedermeyer E . Generalized seizure discharges and possible precipitating mechanisms. Epilepsia 1966; 7: 23–29.

Niedermeyer E . The Epilepsies, Baltimore: Urban and Schwarzenberg; 1990.

Niedermeyer E . Epileptic seizure disorders. In: Niedermeyer E da Silva Lopes F (eds). Electroencephalography, 3rd ed. Baltimore: Williams and Wilkins; 1993: 461–564.

Niedermeyer E . K complex and epilepsy. In: Terzano MG Halász P Declerck AC (eds). Phasic Events and Dynamic Organization of Sleep. New York: Raven Press; 1991: 135–150.

Rodin E Ancheta O . Cerebral electrical fields during petit mal absences. Electroencephalogr Clin Neurophysiol 1987; 66: 457–466.

Lehmann HJ . Praparoxysmale Weckreaktionen bei pyknoleptischen Absenzen. Arch Psychiat Nervenkr 1963; 204: 417–426.

Inouye T Sakamoto K Shinosaki S Toi S Ukai S . Analysis of rapidly changing EEGs before generalized spike and wave complexes. Electroencephalogr Clin Neurophysiol 1990; 76: 205–221.

Niedermeyer E Vaughan-Matthews S . Generalized synchronous paroxysmal bursts and the role of arousal. Electroencephalogr Clin Neurophysiol 1992; 82: 103 (abstract).

Niedermeyer E . Mechanisms of primary generalized epilepsy. Epilepsia 1992; 33: 57 (abstract).

Moruzzi G Magoun HW . Brain stem reticular formation and activation of the EEG. Electroencephalogr Clin Neurophysiol 1949; 1: 455–473.

Lindsley DB Bowden J Magoun HW . Effects upon EEG of acute injury to the brain stem activating system. Electroencephalogr Clin Neurophysiol 1949; 1: 475–486.

Magoun HW . The Waking Brain. Springfield: Thomas; 1958.

Rothballer AB . Studies of adrenaline-sensitive component of the reticular activating system. Electroencephalogr Clin Neurophysiol 1956; 8: 603–621.

Rinaldi F Himwich HE . Cholinergic mechanisms involved in function of mesodiencephalic activating system. Arch Neurol Psychiat 1955; 73: 387–395.

Baumgarten HG . Control of vigilance and behavior by ascending serotonergic systems. In: Zschocke S Speckmann E-J (eds). Basic Mechanisms of the EEG. Boston: Birkhäuser; 1993: 231–268.

Alajouanine T Gastaut H La Syncinesie-Sursaut L‘épilepsie-sursaut à déclenchement sensoriel ou sensitif inopiné. In: Alajouanine T (ed). Bases Physiologiques et Acpects Cliniques de l’Épilepsie. Paris: Masson; 1958: 199–231.

Gastaut H Tassinari CA . Triggering mechanism in epilepsy. The electroclinical point of view. Epilepsia 1966; 7: 85–1138.

Aguglia U Tinuper P Gastaut H . Startle-induced epileptic seizures. Epilepsia 1984; 25: 712–720.

Niedermeyer E Laws ER Jr Walker AE . Depth EEG findings in epileptic with generalized spike-wave complexes. Arch Neurol 1969; 21: 51–58.

Kellaway P Frost JD Jr Crawley JW . The relationship between sleep spindles and spike-and-wave bursts in human epilepsy. In: Avioli M Gloor P Kostopoulos G Naquet R (eds). Generalized Epilepsy. Boston: Birkhäuser; 1990: 36–48.

Hayne RA Belinson L Gibbs FA . Electrical activity of subcortical areas in epilepsy. Electroencephalogr Clin Neurophysiol 1949; 1: 437–445.

Walker AE Marshall C . The contribution of depth recording to clinical medicine. Electroencephalogr Clin Neurohysiol 1964; 16: 88–99.

Bancaud J Talairach J Bonis A Schaub C Szikla G Morel P Bordas-Ferer M . La Stéréo-Electroencéphalographie dans l'Epilepsie. Paris: Masson; 1965.

Gibbs FA Gibbs EL . Atlas of Electroencephalography, 2nd ed, Vol 2. Cambridge (Mass): Addison-Wesley; 1952.

Bennett FE . Intracarotid and intravertebral Metrazol in petit mal. Neurology 1953; 3: 668–673.

Hill RA Chiappa KH Jemkins BG Hunag-Hellinger F . Functional magnetic resonance imaging in primary generalized epilepsy with or without photosensitivity. Epilepsia 1995; 36(Suppl 3): S212 (abstract).

Bates JAV . The unidirectional potential changes in petit mal epilepsy. In: Brazier MAB (ed). Brain Function, Vol 1 (Cortical Excitability and Steady Potentials, Relations of Basic Research to Space Biology). Los Angeles: University of California Press; 1963: 237–279.

Cohn R . DC recordings of paroxysmal disorders in man. Electroencephalogr Clin Neurophysiol 1964; 17: 17–24.

Chatrian GE Somasundaram M Tassinari CA . DC changes recorded transcranially during “typical” three per second spike and wave discharges in man. Epilepsia 1968; 9: 185–209.

Caspers H Speckmann E-J . Postsynaptische Potentiale einzelner Neurone und ihre Beziehungen zum EEG. Z EEG-EMG 1970; 1: 55–65.

Arduini A Mancia M Mechelse K . Slow potential changes elicited in the cerebral cortex by sensory and reticular stimulation. Arch Ital Biol 1957; 95: 127–138.

Caspers H . Relations of steady potential shifts in the cortex to the wakefulness-sleep spectrum. In: Brazier MAB (ed). Brain Function, Vol 1 (Cortical Excitability and Steady Potentials; Relations of Basic Research to Space Biology). Los Angeles: University of California Press; 1963: 173.

O'Leary JL Goldring S . Slow cortical potentials. Their origin and contribution to seizure discharges. Epilepsia 1959/60; 1: 561–574.

Wallstedt L Gazelius B Lind G Meyerson BA Linderoth B . Chronic multifocal recording of cortical microcirculation and subdural EEG during epileptic seizures in humans. Epilepsia 1995; 36(Suppl 3): S146 (abstract).

Tükel K Jasper HH . The electroencephalogram in parasagittal lesions. Electroencephalogr Clin Neurophysiol 1952; 4: 481–494.

Lennox MA Robinson F . Cingulate-cerebellar mechanisms in the pathogenesis of epilepsy. Electroencephalogr Clin Neurophysiol 1951; 3: 197–205.

Walker AE Morello G . Experimental petit mal. Trans Amer Neurol Ass 1967 pp 57–61.

Mazars G . Cingulate gyrus epileptogenic foci as an origin for generalized seizures. In: Gastaut H Jasper HH Bancaud J Waltégny A (eds). The Physiopathogenesis of the Epilepsies. Springfield: Thomas; 1969: 186–189.

Mazars G . Criteria for identifying cingulate epilepsies. Epilepsia 1970; 11: 41–47.

Mazars Y Mazars G Gotusso C Merienne L . Place de l‘épilepsie cingulaire dans le cadre des épilepsies focales. Rev Neurol (Paris) 1966; 114: 215–217.

Bancaud J Talairach J . Clinical semiology of frontal lobe seizures. In: Chauvel P Delgado-Escueta AV Halgren E Bancaud J (eds). Frontal Lobe Seizures and Epilepsies. New York: Raven Press; 1992: 3–58.

Rasmussen T . Surgery of frontal lobe epilepsy. In: Purpura DP Penry JK Walter RD (eds). Neurosurgical Management of the Epilepsies. New York: Raven Press; 1975: 197–205.

Broglin D Delgado-Escueta AV Walsh GO Bancaud J Chauvel P . Clinical approach to the patient with seizures and epilepsies of frontal origin. In: Chauvel P Delgado-Escueta AV Halgren E Bancaud J (eds). Frontal Lobe Seizures and Epilepsies. New York: Raven Press; 1992: 59–88.

Cohn R . Spike-dome complex in the human electroencephalogram. Arch Neurol Psychiat 1954; 71: 699–706.

Janz D . “Nacht“-oder “Schlaf”-Epilepsien. Nervenarzt 1953; 24: 361–367.

Janz D . “Aufwach”-Epilepsien. Arch Psychiat Nervenkr 1953; 191: 73–98.

Janz D . “Diffuse” Epilepsien. Deutsch Z Nervenhk. 1953; 170: 486–513.

Janz D . Pitfalls in the diagnosis of grand mal on awakening. In: Wolf P (ed). Epileptic Seizures and Syndromes. London: Libbey; 1995: 213–220.

Fusco L Faedda MT Manfredi M . Activation of generalized discharges on awakening. Is this EEG feature characteristic of juvenile myoclonic epilepsy? 1995 (Unpublished — Personal Communication).

Janz D . Die Epilepsien. Stuttgart: Thieme; 1969.

Jeavons PM . Photosensitive epilepsies. In: Roger J Dravet C Bureau M Dreifuss FE Wolf P (eds). Epileptic Syndromes in Infancy, Childhood and Adolescence. London: Libbey; 1985: 232–236.

Gobbi G Bruno L Mainetti S Parmeggiani A Tullini A Salvi F . Eye closure seizures. In: Beaumanoir A Gastaut H Naquet R (eds). Reflex Seizures and Reflex Epilepsies. Genève: Editions Médecine et Hygiène; 1989: 181–191.

Bernardina Dalla B Sgro V Fontana E Cellino MR Moser C Zullini E . Eyelid myoclonias with absences. In: Beaumanoir A Gastaut H Naquet R (eds). Reflex Seizures and Reflex Epilepsies. Genève: Editions Médecine et Hygiène; 1989: 193–200.

Binnie CD Darby CE Kasteleijn-Nolst Trenité DGA Wilkins AJ . Photosensitive epilepsy: Clinical features. In: Beaumanoir A Gastaut H Naquet R (eds). Reflex Seizures and Reflex Epilepsies. Genève: Editions Médecine et Hygiène; 1989: 163–170.

Kasteleijn-Nolst Trenité DGA . Photosensitivity in Epilepsy. Thesis. Utrecht. University: 1989.

Gastaut H . A new type of epilepsy: Benign partial epilepsy of childhood with occipital spike-waves. Clin Electroencephalogr 1982; 13: 13–22.

Panayiotopoulos CP . Fixation-off epilepsy. In: Beaumanoir A Gastaut H Naquet R (eds). Reflex Seizures and Reflex Epilepsies. Genève: Editions Médecine et Hygiène; 1989: 203–217,.

Gumnit RJ Niedermeyer E Spreen O . Seizure activity uniquely inhibited by patterned vision. Arch Neurol 1965; 13: 363–368.

Beaumanoir A Capizzi G Nahory A Yousli Y , Scotogenic seizures. In: Beaumanoir A Gastaut H Naquet R (eds). Reflex Seizures and Reflex Epilepsies. Genève: Editions Médecine et Hygiène; 1989: 219–223.

Newmark ME Penry JK . Photosensitivity and Epilepsy: A Review. New York: Raven Press; 1979.

Doose H Gerken H Hien-Volpel KF Völzke E . Genetics of photosensitive epilepsy. Neuropaediatrie 1969; 1: 56–73.

Hauser WA Anderson VA Rich SS . Effect of photoconvulsive response (PCR) on the occurrence of seizures and of generalized EEG patterns in sib-lings of generalized spike and wave (GSW) probands. Electroencephalogr Clin Neurophysiol 1983; 56: 27P (abstract).

Baier WK Doose H . Interdependence of different genetic EEG patterns in siblings of epileptic patients. Electroencephalogr Clin Neurophysiol 1987; 66: 483–488.

Pedley TA . The use and role of EEG in the genetic analysis of epilepsy. In: Anderson VE Hauser WA Leppik IE Noebels JL Rich SS (eds). Genetic Strategies in Epilepsy Resarch. Amsterdam: Elsevier; 1991: 31–44.

Dalby MA . Epilepsy and 3 per second spike and wave rhythms. Copenhagen: Munksgaard; 1969.

Binnie C Van Emde Boas W Kasteleijn-Noslt Trenité DGA de Korte RA Meijer JWA Meinardi H . Acute effects of Lamotrigine (BW430C) in persons with epilepsy. Epilepsia 1986; 27: 248–254.

Messenheimer JA . Lamotrigine. Epilepsia 1995; 36(Suppl 2): S87–S94.

Fromm GH Kohli CM . The role of inhibitory pathways in petit mal epilepsy. Neurology 1972; 22: 1012–1020.

Fromm GH . Animal models of generalized convulsive disorders. In: Klawans HL (ed). Models in Human Neurological Disease. Amsterdam: Excerpta Medica; 1974: 149–165.

Fromm GH Glass JD Chattha AS . The role of cholinergic mechanisms in the corticofugal inhibition of the spinal trigeminal nucleus. Electroencephalogr Clin Neurophysiol 1979; 46: 302–309.

Fromm GH . Role of inhibitory mechanisms in staring spells. J Clin Neurophysiol 1986; 3: 297–311.

Faingold CL Fromm GH . Drugs for Control of Epilepsy. Boca Raton: CRC Press; 1992.

Fromm GH . Antiepileptic drugs useful in the treatment of absence seizures. In: Faingold CL Fromm GH . Drugs for Control of Epilepsy. Boca Raton: CRC Press; 1992: 507–511.

Mirsky AF Duncan CC Myslobodsky MS . Petit mal epilepsy: A review and integration of recent information. J Clin Neurophysiol 1986; 3: 179–208.

Berkovic SF Andermann F Andermann E Gloor P . Concepts of absence epilepsies; discrete syndromes or biological continuum. Neurology 1987; 37: 993–1000.

Reutens DC Berkovic SF . Idiopathic generalized epilepsy of adolescence: Are the syndromes clinically distinct? Neurology 1995; 45: 1469–1475.

Bauer G Benke T Bohr K . The Lennox-Gastaut syndrome in adulthood. In: Niedermeyer E Degen R (eds). The Lennox-Gastaut Syndrome. New York: Liss; 1988: 317–327.