After a brief discussion of the historical aspects of the Lennox-Gastaut syndrome, the electroencephalographic, epileptological and other clinical characteristics are presented.
This severe and almost intractable seizure disorder must be distinguished from a variety of other epileptic conditions which may electro-encephalographically mimick the Lennox-Gastaut syndrome.
WestW.J., On a peculiar form of infantile convulsion, Lancet, 1:724, 1841.
2.
GibbsF.A., GibbsE.L., and LennoxW.G., The influence of the blood sugar level on the wave and spike formation in petit mal epilepsy, Arch. Neurol. Psychiat. (Chicago), 47:1111–1116, 1939.
3.
LennjoxW.G., Epilepsy and Related Disorders, Little, Brown and Co., Boston, 1960.
4.
GastautH., RogerJ., SoulayrolR., TassinariC.T., RegisH., DravetC., BernardR., PinsardN., and Saint-JeanM., Childhood epileptic encephalopathy with diffuse slow spike-waves (otherwise known as “petit mal variant”) or Lennox syndrome, Epilepsia (Amsterdam), 7:139–179,1966.
5.
SorelL., L'epilepsie myokinetique grave de'la prémière enfance avec pointeonde lente (Petit mal variant) et son traitement, Rev. neurol. (Paris), 99:136–138, 1964.
6.
Oller-DaurellaL., Sindrome de Lennox, Editorial Expaxc, Barcelona, 1967.
7.
BeaumanoirA., MartinF., Panagopou-LosM., and MundlerF., Le syndrome de Lennox (etude evolutive de trente cas), Schweiz. Arch. Neurol. Psychiatr., 102:31–62, 1968.
8.
NiedermeyerE., The Lennox-Gastaut syndrome: A severe type of childhood epilepsy, Electroenceph. clin. Neurophysiol., 24:283 (abstract), 1968.
9.
BambergerP., and MatthesA., Anfälle im Kindesalter, Karger, Basel, 1959.
10.
KruseR., Das Myoklonisch-Astatische Petit Mal, Springer, Berlin, 1968.
11.
PatryG., LyagoubiS., and TassinariC.T., Subclinical “status epilepticus” induced by sleep in children, Arch. Neurol (Chicago), 24:242–252, 1971.
12.
GibbsF.A., LennoxW.G., and GibbsE.L., The electroencephalogram in diagnosis and in localization of epileptic seizures, Arch. Neurol. Psychiat. (Chicago), 36:1225–1235, 1936.
13.
GibbsF.A., and GIBBSE. L., Atlas of Electroencephalography, 2nd ed., Vol. 2, Addison-Wesley, Cambridge (Mass), 1952.
14.
KomaiS., Lennox-Gastaut's syndrome. Prognosis of the secondary generalized epilepsies, Epilepsia (New York), 18:131 (abstract), 1977.
15.
GastautH., GastautJ.L., Goncalves e SilvaE., and SanchesG.R., Relative frequency of different types of epilepsy. A study employing the classifications of the International League against Epilepsy, Epilepsia (New York), 16:457–461, 1975.
16.
HuntI.R., On the occurrence of static seizures in epilepsy, J. Nerv. Ment. Dis., 56:351–356, 1922.
17.
LennoxW.G., The petit mal epilepsies, their treatment with tridione, J. A.M.A., 129:1069–1074, 1945.
18.
BridgeE.M., Epilepsy and convulsive disorder in children, McGraw-Hill, New York, 1949.
19.
DooseH., Das akinetische Petit mal, Arch. Psychiat. Nervenkr., 205:625–654, 1964.
20.
GastautH., and BroughtonR., Epileptic Seizures, Springfield, 1972.
21.
Oller-DaurellaL, and de Crisis Epilepticas Oller-Ferrer-VidalAtlas, Geigy, Basel, 1977.
22.
LipinskiG.G., Epilepsies with static seizures of late onset, Epilepsia (New York), 18:13–20, 1977.
23.
BauerG., AichnerF., and SaltuariL., Epilepsies with diffuse slow spikes and waves of late onset, European Neurol. (Basel), 22:344–350, 1983.
24.
BrettE.M., Minor epileptic status, J. neurol. sci., 3:53–75, 1966.
25.
LagersteinI., and IfllandE., Die intra-venöse Behandlung des Petit-Mai-Status mit Diazepam und Clonazepam, Z EEG-EMG, 8:82–88,1977.
26.
GastautH., RogerJ., and LobH., Les Etats de Mal Epileptiques, Masson, Paris, 1967.
27.
PriorP.F., MaclaineC.N., ScottD.F., and LauranceB.M., Tonic status epilepticus precipitated by intravenous diazepam in a child with petit mal status, Epilepsia (Amsterdam), 13:467–472, 1972.
28.
TassinariC.A., DravetC., RogerJ., CanoJ.P., and GastautH., Tonic status epilepticus precipated by intravenous benzodiazepine in five patients with Lennox-Gastaut syndrome, Epilepsia (Amsterdam), 13:421–435, 1972.
29.
GastautH., A new type of epilepsy: Benign partial epilepsy of childhood with occipital spike-waves, Clin. Electroenceph., 13:13–22, 1982.
30.
NiedermeyerE., WalkerA.E., and BurtonC., The slow spike-wave complex as a correlate of frontal and frontotemporal posttraumatic epilepsy, Europ. Neurol. (Basel), 3:330–346, 1970.
31.
TassinariC.A., DanieleO., DravetC, BureauM., Dalaa BernardinaB., Michel-LucciR., Picornell-DarderI., VigevanoF., and RogerJ., Sleep polygraphic studies in some epileptic encephalopathies from infancy to adolescence. In DegenR. and NiedermeyerE. (eds.), Epilepsy, Sleep and Sleep Deprivation, Amsterdam, Elsevier, pp. 175–189, 1984.
32.
RodriguezI., and NiedermeyerE., The aphasia-epilepsy syndrome in children: Electro-encephalographic aspects, Clin. Electroenceph., 13:23–35, 1982.
33.
NiedermeyerE., RettA., RennerH., MurphyM., and NaiduS., Rett syndrome and the electroencephalogram, Am. J. med. Genetics, 24:195–199, 1986.
34.
GatesJ.R., LeppikI.E., YapJ., and GumnitR.J., Corpus callosotomy: Clinical and electro-encephalographic effects, Epilepsia (New York), 25:308–316, 1984.