Effect of Different Doses of Valproic Acid on the Serum Levels of Total and Free Diphenylhydantoin

Pinder R.M. Brodgen R.N. Speight T.M. , and Avery G.S. , Sodium Valproate: A Review of its Pharmacological Properties and Therapeutic Efficacy in Epilepsy, Drugs, 13:81–123, 1977.

Keys P.A. , Valproic Acid: Interactions with Phenytoin and Phenobarbital, Drug Intell. Clin. Pharmacol., 16:737–739, 1982.

Levy R.H. , and Koch K.M. , Drug Interactions with Valproic Acid, Drugs, 24:543–556, 1982.

Lunde P.K.M. Rane A. Yalle S.J. Lund L. , and Sjogvist F. , Plasma Protein Binding of Diphenylhydantoin, Man. Clin. Pharmacol. Ther., 11:846–855, 1970.

Gram L. Flachs E. Jorgensen A. Parnas O. , and Anderson B. , Sodium Valproate, Serum Level, and Clinical Effect in Epilepsy: A Controlled Study, Epilepsia, 20:303–312, 1979.

Richens A. Scoular I.T. Ahmand S. , and Jordan B.J. The Effects of Sodium Valproate (Epilim) on Phenytoin and Phenobarbitone Blood Levels. In Leggs (Ed.), Clinical and Pharmacological Aspects of Sodium Valproate (Epilim) in the Treatment of Epilepsy, MCS Consultants, Tunbridge Wells, 1976, pp. 78–88.

Vajda F. Morris P. Drummer O. , and Bladin P. , Studies on Sodium Valproate - A New Anticonvulsant. In Legg (Ed.), Clinical and Pharmacological Aspects of Sodium Valproate (Epilim) in the Treatment of Epilepsy, MCS Consultants, Turnbridge Wells, 1976, pp. 92–100.

Bardy A. Hari R. Lehtovaara R. , and Majuri H. , Valproate May Lower Serum Phenytoin, Lancet, 1:1256–1257, 1976.

Monks A. , and Richens A. , Effects of a Single Dose of Sodium Valproate on Serum Phenytoin Levels and Protein Binding in Epileptic Patients, Clin. Pharmacol. Ther., 27:89–95, 1980.

Mattson R.H. Cramer J.A. Williamson P.D. , and Novelly R. , Valproic Acid In Epilepsy: Clinical and Pharmacological Effects, Ann. Neurol., 3:20–25, 1978.

Gram L. Wulff K. Rasmussen K.E. Flachs H. Wurtz-Jorgensen A. Sommerbeck K.W. , and Lohien V. , Valproate Sodium: A Controlled Clinical Trial Including Monitoring of Drug Levels, Epilepsia, 18 (2), 1977.

Bruni J. Gallo J.M. Lee C.S. Perchalsk R.S. , and Wilder B.J. , Interactions of Valproic Acid with Phenytoin, Neurology, 30:1233–36, 1980.

Vakil S.D. Crichtley E.M.R. Phillips J.C. Fahim Y. Haydock C. Cocks A. , and Dyer T. , Effect of Sodium Valproate (Epilim) on Phenytoin and Phenobarbitone Blood Levels. In Legg (Ed.). Clinical and Pharmacological Aspects of Sodium Valproate (Epilim) in the Treatment of Epilepsy, MCS Consultant, Tunbridge Wells, 1976, pp. 75–77.

Windofer A. Sauer W. , and Gadeke R. , Elevation of Diphenylhydantoin and Primidone Serum Concentration by Addition of Dipropylacetate, a New Anticonvulsant Drug, Acta Paediatr. Scand., 64:771–775, 1975.

Perucca E. Hebdige S. Frigo G.M. Gatti G. Lecchini S. , and Crema A. , Interaction Between Phenytoin and Valproic Acid: Plasma Protein Binding and Metabolic Effects, Clin. Pharmacol. Ther., 28 (6), 1980.

Loiseau P. Brachet A. , and Henry P. , Concentration of Dipropylacetate in Plasma, Epilepsia, 16:609–15, 1975.

Booker H.E. , and Darcey B. , Serum Concentration of Free Diphenylhydantoin and Their Relationship to Clinical Intoxication, Epilepsia, 14:177–184, 1973.

Eadie M.J. , Plasma Level Monitoring of Anticonvulsants, Clin. Pharmacokin., 1:52–66, 1976.

Kober A. Olsson Y. , and Sjoholm I. , Bindings of Drugs to Human Serum Albumin. The Theoretical Basis for the Interaction Between Phenytoin and Valproate, Mol. Pharmacol., 18:237–242, 1980.

Cramer J.A. , and Mattson R.H. , Valproic Acid: In Vitro Plasma Protein Binding and Interactions with Phenytoin, Therapeutic Drug Monitoring, 1:105–116, 1979.