Event-Related Potential Analysis of ADHD and Control Adults During a Sustained Attention Task

Abstract

Background. Event-related potentials (ERPs) of attention deficit hyperactivity disorder (ADHD) population have been extensively studied using the time-domain representation of signals but time-frequency domain techniques are less explored. Although, adult ADHD is a proven disorder, most of the electrophysiological studies have focused only on children with ADHD. Methods. ERP data of 35 university students with ADHD and 35 control adults were recorded during visual continuous performance task (CPT). Gray level co-occurrence matrix-based texture features were extracted from time-frequency (t-f) images of event-related EEG epochs. Different ERP components measures, that is, amplitudes and latencies corresponding to N1, N2, and P3 components were also computed relative to standard and target stimuli. Results. Texture analysis has shown that the mean value of contrast, dissimilarity, and difference entropy is significantly reduced in adults with ADHD than in control adults. The mean correlation and homogeneity in adults with ADHD were significantly increased as compared with control adults. ERP components analysis has reported that adults with ADHD have reduced N1 amplitude to target stimuli, reduced N2 and P3 amplitude to both standard and target stimuli than controls. Conclusions. The differences in texture features obtained from t-f images of ERPs point toward altered information processing in adults with ADHD during a cognitive task. Findings of reduction in N1, N2, and P3 components highlight deficits of early sensory processing, stimulus categorization, and attentional resources, respectively, in adults with ADHD.