In the research field of epilepsy, it is a challenge to understand the transition of brain activity to electrical status epilepticus in sleep (ESES). In this study, an S-estimator method is proposed to describe the course of global synchronization in multichannel electroencephalograph (EEG) from awake to sleep in 11 patients with ESES. The study confirms that there is a significant increase in spikes and global synchronization from awake to sleep. It is also found that global synchronization is strongly correlated with spikes. The proposed method has the potential of revealing the intrinsic features of EEG signals and the underlying brain dynamics in ESES.
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