The Prognostic Significance of Interictal Epileptiform Activity in Postoperative EEGs of Patients with Mesial Temporal Lobe Epilepsy

Abstract

It has not been established whether electroencephalography (EEG) is a contributing factor in predicting the outcome of surgery for epilepsy. We conducted a prospective study on 26 patients (M/F 14/12, age: 33 ± 7.5 years, range 19–48) with mesial temporal lobe epilepsy (MTLE) who were followed for 2 years after surgery and who underwent routine EEG recordings 5.6 ± 3 months (range 3–12) postoperatively. Interictal epileptiform activity (IEA) on the EEG was compared in 17 seizure-free patients to 9 patients with recurrent seizures. The two groups were similar in gender, age, febrile convulsions, trauma, family history, seizure frequency prior to surgery, epilepsy duration and number of antiepileptic drugs.

Following surgery, 17 study patients (65%) became seizure free; 9 (35%) had seizure recurrence. Postoperative EEG recordings showed IEA in 8/26 study patients (31%), 3 of whom were from the seizure-free group (3/17, 18%); 5 had seizure recurrence (5/9, 56%) (p=0.078). IEAs in postoperative EEGs were less frequently demonstrated in patients who were seizure free, but the presence of postoperative IEAs does not preclude successful surgical outcome.

Keywords

Electroencephalography Epilepsy Surgery Outcome Interictal Epileptiform EEG Temporal Lobe Epilepsy

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