Cognitive event-related potential (ERP) studies of memory and language impairments in amnesia and Alzheimer's disease (AD) are reviewed. Well-circumscribed lesions of the medial temporal lobe (MTL) or diencephalon causing an amnestic syndrome, an inability to encode and retrieve episodic memories beyond the brief duration of working memory, appear to produce altered plasticity of the late positive P600 component, but usually spare P300 and N400 components. The neuropathology of AD affects MTL and extends to neocortical association areas, causing deficits of episodic and semantic memory. In AD dementia, the P300, N400, and P600 all commonly show abnormalities. ERP studies of individuals with mild cognitive impairment may reveal neurophysiological changes prior to the emergence of clinical deficits, which could advance the early detection and diagnosis of AD.
SquireLRKnowltonBMusenG.The structure and organization of memory. Annu Rev Psychol1993;44:453–495.
2.
OlichneyJMVan PettenCPallerKSalmonDPIraguiVJKutasM.Word repetition in amnesia: Electrophysiological measures of impaired and spared memory. Brain2000;123:1948–1963.
3.
AuchterlonieSPhillipsPAChertkowH.Behavioral and electrical brain measures of semantic priming in patients with Alzheimer's disease: Implications for access failure versus deterioration hypotheses. Brain Cogn2002;48(2–3): 264–267.
4.
DonchinEColesMGHIs the P300 component a manifestation of context updating?Behav Brain Sci1988;11(3): 357–374.
5.
VerlegerR.Event-related potentials and cognition: A critique of the context updating hypothesis and an alternative interpretation of P3. Behav Brain Sci1988;11:343–356.
6.
JohnsonRJr.. A triarchic model of P300 amplitude. Psychophysiology1986;23(4): 367–384.
7.
HalgrenEMarinkovicKChauvelP.Generators of the late cognitive potentials in auditory and visual oddball tasks. Electroencephalogr Clin Neurophysiol1998;106(2): 156–164.
8.
GuillemFRougierAClaverieB.Short- and long-delay intracranial ERP repetition effects dissociate memory systems in the human brain. J Cogn Neurosci1999;11(4): 437–458.
9.
YamaguchiSKnightRTEffects of temporal-parietal lesions on the somatosensory P3 to lower limb stimulation. Electroencephalogr Clin Neurophysiol1992;84(2): 139–148.
10.
RuggMDPicklesCDPotterDDRobertsRCNormal P300 following extensive damage to the left medial temporal lobe. J Neurol Neurosurg Psychiatry1991;54(3): 217–222.
11.
TachibanaHMiyataYTakedaMMinamotoHSugitaMOkitaT.Auditory event-related potentials in an amnesic patient with a left temporal lobe lesion. J Neurol Sci1999;168(1): 52–56.
12.
OnofrjMGambiDFulgenteTBazzanoSColamartinoP.Persistence of a P3 component in severe amnestic syndrome. Electroencephalogr Clin Neurophysiol1991;78(6): 480–484.
13.
PotterDPicklesCRobertsRRuggMPallerKMayesA.Visual and auditory P300 in a case of bilateral destruction of the medial temporal lobes following viral encephalitis. In: HeinzeHJMunteTMangunG, (eds). Cognitive Electrophysiology: Event-related Brain Potentials in Basic and Clinical Research. Boston: Birkhauser Books; 1993: 303–311.
14.
PolichJSquireLRP300 from amnesic patients with bilateral hippocampal lesions. Electroencephalogr Clin Neurophysiol1993;86(6): 408–417.
15.
HondaMSuwazonoSNagamineTYonekuraYShibasakiH.P300 abnormalities in patients with selective impairment of recent memory. J Neurol Sci1996;139(1): 95–105.
16.
GoodinDSAminoffMJElectrophysiological differences between subtypes of dementia. Brain1986;109(6): 1103–1113.
17.
FordJMPfefferbaumA.Age-related changes in event-related potentials. Advances Psychophysiology1985;1:301–339.
18.
SquiresKCChippendaleTJWregeKSGoodinDSStarrA.Electrophysiological assessment of mental function in aging and dementia. In: PoonL, (ed). Aging in the 1980s. Washington, DC: American Psychology Association; 1980: 125–134.
19.
GordonEKraiuhinCHarrisAMearesRHowsonA.The differential diagnosis of dementia using P300 latency. Biolog Psychiatry1986;21:1123–1132.
20.
GoodinDSClinical utility of long latency “cognitive” event-related potentials (P3): The pros. Electroencephalogr Clin Neurophysiol1990;76(1): 2–5.
21.
PfefferbaumAWenegratBGFordJMRothWTKopellBSClinical application of the P3 component of event-related potentials. II: Dementia, depression and schizophrenia. Electroencephalogr Clin Neurophysiol1984;59(2), 104–124.
22.
PattersonJVMichalewskiHJStarrA.Latency variability of the components of auditory event-related potentials to infrequent stimuli in aging, Alzheimer-type dementia, and depression. Electroencephalogr Clin Neurophysiol1988;71(6): 450–460.
23.
OlichneyJMHillertDGClinical applications of cognitive event-related potentials in Alzheimer's disease. Phys Med Rehabil Clin N Am2004;15(1): 205–233.
24.
PolichJPitzerA.P300 and Alzheimer's disease: Oddball task difficulty and modality effects. Electroencephalogr Clin Neurophysiol1999; (suppl) 50: 281–287.
25.
MorganCDMurphyC.Olfactory event-related potentials in Alzheimer's disease. J Int Neuropsychol Soc2002;8(6): 753–763.
26.
TanakaFKachiTYamadaTSobueG.Auditory and visual event-related potentials and flash visual evoked potentials in Alzheimer's disease: Correlations with Mini-Mental State Examination and Raven's Coloured Progressive Matrices. J Neurol Sci1998;156(1): 83–88.
27.
GolobEJJohnsonJKStarrA.Auditory event-related potentials during target detection are abnormal in mild cognitive impairment. Clin Neurophysiol2001;113(1): 151–161.
28.
FrodlTHampelHJuckelGBurgerKPadbergFEngelRRMollerHJHegerlU.Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease. Psychophysiology2002;39(2): 175–181.
29.
GironellAGarcia-SanchezCEstevez-GonzalezABoltesAKulisevskyJ.Usefulness of P300 in subjective memory complaints: A prospective study. J Clin Neurophysiol2005;22(4): 279–284.
KutasMNevilleHJHolcombPJA preliminary comparison of the N400 response to semantic anomalies during reading, listening and signing. Electroencephalogr Clin Neurophysiol (suppl)1987;39:325–330.
32.
McCarthyGNobreACBentinSLanguage-related field potentials in the anterior-medial temporal lobe: 1. Intracranial distribution and neural generators. J Neurosci1995;15(2): 1080–1089.
33.
NobreACAllisonTMcCarthyG.Word recognition in the human inferior temporal lobe. Nature1994;372(6503): 260–263.
34.
HalgrenEBaudenaPHeitGSpatio-temporal stages in face and word processing: Depth recorded potentials in the human occipital and parietal lobes. J Physiol (Lond)1994;88:1–50.
35.
KutasMVan PettenC.Event-related brain potential studies of language. In: AcklesPKJenningsJRColesMGH, (eds). Advances in Psychophysiology, vol. 3. Greenwich, CT: JAI Press; 1988: 139–187.
36.
OsterhoutLHolcombPJEvent-related potentials and language comprehension. In: RuggMDColesMGH, (eds). Electrophysiology of Mind: Event-related Brain Potentials and Cognition. Oxford, UK: Oxford University Press; 1995: 171–215.
37.
MonschAUBondiMWButtersNSalmonDPKatzmanRThalLJComparisons of verbal fluency tasks in the detection of dementia of the Alzheimer type. Arch Neurol1992;49(12): 1253–1258.
38.
SalmonDPButtersNChanASThe deterioration of semantic memory in Alzheimer's disease. Can J Exp Psychol1999;53(1): 108–117.
39.
ChanASButtersNSalmonDP. The deterioration of semantic networks in patients with Alzheimer's disease: A cross-sectional study. Neuropsychologia199735(3): 241–248.
40.
OberBAShenautGKSemantic priming in Alzheimer's disease: Meta analysis and theoretical evaluation. In: AllenPABashoreTR, (eds). Advances in Psychology: Age Differences in Word and Language Processing. Amsterdam: Elsevier; 1995: 247–271.
41.
KingJKutasM.Do the waves begin to waver? ERP studies of language processing in the elderly. In: AllenPABashoreTR, (eds). Advances in Psychology: Age Differences in Word and Language Processing. Amsterdam: Elsevier; 1995: 314–344.
42.
KutasMIraguiV.The N400 in a semantic categorization task across 6 decades. Electroencephalogr Clin Neurophysiol1998;108:456–471.
43.
IraguiVKutasMSalmonDPEvent-related brain potentials during semantic categorization in normal aging and senile dementia of the Alzheimer's type. Electroencephalog Clin Neurophysiol1996;100:392–406.
44.
HambergerMJFriedmanDRitterWRosenJ.Event-related potential and behavioral correlates of semantic processing in Alzheimer's patients and normal controls. Brain Lang1995;48(1): 33–68.
45.
FordJMWoodwardSHSullivanEVIsaacksBGTinklenbergJRYesavageJARothWTN400 evidence of abnormal responses to speech in Alzheimer's disease. Electroencephalogr Clin Neurophysiol1996;99(3): 235–246.
46.
RevonsuoAPortinRJuottonenKRinneJOSemantic processing of spoken words in Alzheimer's disease: An electrophysiological study. J Cogn Neurosci1998;10(3): 408–420.
47.
SchwartzTJKutasMButtersNElectrophysiological insights into the nature of the semantic deficit in Alzheimer's disease. Neuropsychologia1996;34(8): 827–841.
48.
FordJMAskariNMathalonDHMenonVGabrieliJDTinklenbergJRYesavageJ.Event-related brain potential evidence of spared knowledge in Alzheimer's disease. Psychol Aging2001;16(1): 161–176.
49.
CastañedaMOstrosky-SolisFPerezMBobesMARangelLEERP assessment of semantic memory in Alzheimer's disease. Int J Psychophysiol1997;27(3): 201–214.
50.
Ostrosky-SolisFCastañedaMPerezMCastilloGBobesMACognitive brain activity in Alzheimer's disease: Electrophysiological response during picture semantic categorization. J Int Neuropsychol Soc1998;4(5): 415–425.
51.
Van PettenCKutasMKluenderRMitchinerMMcIsaacH.Fractionating the word repetition effect with event related potentials. J Cogn Neurosci1991;3:131–150.
52.
PallerKAKutasM.Brain potentials during memory retrieval provide neurophysiological support for the distinction between conscious recollection and priming. J Cogn Neurosci1992;4:375–391.
53.
PallerKAKutasMMayesARNeural correlates of encoding in an incidental learning paradigm. Electroencephalogr Clin Neurophysiol1987;67:360–371.
54.
FernandezGWeyertsHTendolkarISmidHGScholzMHeinzeHJEvent-related potentials of verbal encoding into episodic memory: Dissociation between the effect of subsequent memory performance and distinctiveness. Psychophysiology1998;35:709–720.
55.
RuggMDMarkREWallaPSchloerscheidtAMBirchCSAllanK.Dissociation of the neural correlates of implicit and explicit memory. Nature1998;392:595–598.
56.
GrunwaldTElgerCELehnertzKVan RoostDHeinzeHJAlterations of intrahippocampal cognitive potentials in temporal lobe epilepsy. Electroencephalogr Clin Neurophysiol1995;95(1): 53–62.
57.
HelmstaedterCGrunwaldTLehnertzKGleissnerUElgerCEDifferential involvement of left temporolateral and temporomesial structures in verbal declarative learning and memory: Evidence from temporal lobe epilepsy. Brain Cogn1997;35(1): 110–131.
58.
SmithMEHalgrenE.Dissociation of recognition memory components following temporal lobe lesions. J Exp Psychol Learn Mem Cogn1989;15:50–60.
59.
MecklingerAvon CramonDYMatthes-vonCramon G. Event-related potential evidence for a specific recognition memory deficit in adult survivors of cerebral hypoxia. Brain1998;121(Pt 10): 1919–1935.
60.
LalouschekWGoldenbergGMartererABeisteinerRLindingerGLangW.Brain/behaviour dissociation on old/new distinction in a patient with amnesic syndrome. Electroencephalogr Clin Neurophysiol1997;104(3): 222–227.
61.
FriedmanDHambergerMSternYMarderK.Event-related potentials (ERPs) during repetition priming in Alzheimer's patients and young and older controls. J Clin Exp Neuropsychol1992;14(4): 448–462.
62.
RuggMDPearlSWalkerPRobertsRCHoldstockJSWord repetition effects on event-related potentials in healthy young and old subjects, and in patients with Alzheimer-type dementia. Neuropsychologia1994;32(4): 381–398.
63.
TendolkarISchoenfeldAGolzGFernandezGKuhlKPFersztRHeinzeHJNeural correlates of recognition memory with and without recollection in patients with Alzheimer's disease and healthy controls. Neurosci Lett1999;263(1): 45–48.
64.
SchnyerDMAllenJJKaszniakAWForsterKIAn event-related potential examination of masked and unmasked repetition priming in Alzheimer's disease: Implications for theories of implicit memory. Neuropsychology1999;13(3): 323–337.
65.
OlichneyJMRigginsBRMorrisSKSalmonDPKutasMIraguiVJReduced effects of word repetition on the N400 and LPC event-related potentials are common in mild Alzheimer's disease and Mild Cognitive Impairment converters. Neurology2002, 58 (suppl 3) A216.
66.
KeaneMGabrieliJFennemaAEvidence for a dissociation between perceptual and conceptual priming in Alzheimer's disease. Behav Neurosci1991;105:326–342.
67.
OlichneyJMMorrisSKOchoaCSalmonDPThalLJKutasMIraguiVJAbnormal verbal event-related potentials in mild cognitive impairment and incipient AD. J Neurol Neurosurg Psychiatry2002;73:377–384.
68.
SelkoeDJAlzheimer's disease is a synaptic failure. Science2002 Oct 25; 298(5594): 789–791.
69.
MesulamMMNeuroplasticity failure in Alzheimer's disease: Bridging the gap between plaques and tangles. Neuron1999;24(3): 521–529.
70.
MoecharsDDewachterILorentKEarly phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem1999;274(10): 6483–6492.
71.
RowanMJKlyubinICullenWKAnwylR.Synaptic plasticity in animal models of early Alzheimer's disease. Philos Trans R Soc Lond B Biol Sci2003;358(1432): 821–828.
72.
TerryRDMasliahESalmonDPButtersNDeTeresaRHillRHansenLAKatzmanR.Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol1991;30(4): 572–580.
73.
BraakHBraakE.Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl)1991;82(4): 239–259
