Building on prior research, which has suggested a relationship between aggression and left frontal activity, our study tested the hypothesis that proneness to impulsive aggression would be related to relative left frontal overactivation. EEG one-hertz resting alpha power frontal asymmetry was examined in 65 pediatric male psychiatric patients with a history of impulsive aggression and comorbid mood and disruptive behavior disorders.
The strongest finding, which emerged from this analysis, was a finding of relative increases in left frontal activity compared with right frontal activity. The results also indicated that greater left frontal activity correlated positively with the severity of psychiatric disturbance. These findings suggest that relative increases in left frontal activity may be related to a locus of neurophysiological disruption associated with psychopathology characterized by behavioral and affective disinhibition. Results are discussed within a model of behavioral inhibition system-behavioral activation system theory.
HenriquesJBDavidsonRJ. Regional brain electrical asymmetries discriminate between previously depressed and healthy control subjects. J Abnorm Psychol1990;99(1):22–31.
2.
HenriquesJBDavidsonRJ. Left-frontal hypoactivation in depression. J Abnorm Psychol1991;100:538–545.
3.
SchafferCEDavidsonRJSaronC. Frontal and parietal electroencephalogram asymmetry in depressed and nondepressed subjects. Biol Psychiat1983;18(7):753–762.
Harmon-JonesE. Clarifying the emotive functions of asymmetrical frontal cortical activity. Psychophysiology2003;40:838–848.
6.
Harmon-JonesESigelmanJ. State anger and prefrontal brain activity: evidence that insult-related relative left-pre-frontal activation is associated with experienced anger and aggression. J Pers Soc Psychol2001;80(5):797–803.
7.
DavidsonRJ. Anterior electrophysiological asymmetries, emotion, and depression: conceptual and methodological conundrums. Psychophysiology1998;35:607–614.
8.
CoanJAAllenJJB. Frontal EEG asymmetry and the behavioral activation and inhibition systems. Psychophysiology2003;40:106–114.
9.
Harmon-JonesEAllenJJB. Behavioral activation sensitivity and resting frontal EEG asymmetry: covariation of putative indicators related to risk for mood disorders. J Abnorm Psychol1997;106:159–163.
10.
ChabotRSerfonteinG. Quantitative electroencephalographic profiles of children with attention deficit disorder. Biol Psychiat1996;40:951–963.
11.
ClarkeARBarryRJMcCarthyRSelikowitzM. EEG analysis in Attention-Deficit/Hyperactivity Disorder: a comparative study of two subtypes. Psychiat Res1998;81:19–29.
12.
MatousekMRasmussenPGilbergC. EEG frequency analysis in children with so called minimal brain dysfunction and related disorders. Advanc Biol Psychiat1984;15:102–108.
Harmon-JonesEAllenJJB. Anger and prefrontal brain activity: EEG asymmetry consistent with approach motivation despite negative affective valence. J Pers Soc Psychol1998;74:1310–1316.
17.
EkmanPDavidsonRJ. Affective science: A research agenda. In: EkmanPDavidsonRJ, (eds). The Nature of Emotion: Fundamental Questions. New York: Oxford University Press; 1994: 411–430.
18.
LevensonRW. The research for autonomic specificity. In: EkmanPDavidsonRJ, (eds). The Nature of Emotion: Fundamental Questions. New York: Oxford University Press; 1994: 252–257.
19.
PlutchikR. Emotion: A Psychoevolutionary Synthesis. New York: Harper and Row, 1980.
20.
GrayJA. Three fundamental emotion systems. In: EkmanPDavidsonRJ, (eds). The Nature of Emotion: Fundamental Questions. New York: Oxford University Press, 1994:243–247.
21.
GableSLReisHTElliotAJ. Behavioral activation and inhibition in everyday life. J Pers Soc Psychol2000;78:1135–1149.
22.
WingroveJBondAJ. Angry reactions to failure on a cooprative computer game: the effect of trait hostility, behavioral inhibition, and behavioral activation. Aggress Behav1998;24:27–36.
23.
GoldenZLGoldenCJ. Do early onset conduct disordered adolescents perform like brain injured or normal adolescents on cognitive tests?Int J Neurosci2001;111:109–121.
24.
MoffittTEHenryB. Neuropsychological studies of juvenile delinquency and violence: a review. In: MilnerJ, (ed). The Neuropsychology of Aggression. Norwell, MA: Kluwer Academic; 1991.
25.
YeudallLT. Neuropsychological assessment of forensic disorders. Canada's Mental Health1977;25:7–15.
26.
Flor-HenryP. Lateralized temporal-limbic dysfunction and psychopathology. In: HarnardSRSteklisHDLancasterJ, (eds). Origins and Evolutions of Language and Speech, New York: New York Academy of Sciences; 1976.
27.
WardellDYeudallLT. A multidimensional approach to criminal disorders: The assessment of impulsivity and its relation to crime. Advanc Behav Res Therapy1980;2:159–177.
28.
FedoraOFedoraS. Some neuropsychological and psychophysiological aspects of psychopathic and nonpsychopathic criminals. In: Flor-HenryPGruzelierJ, (eds). Laterality and Psychopathology. Amsterdam: Elsevier; 1983.
29.
GabrielliWFMednickSA. Sinistrality and delinquency. J Abnorm Psychol1980;89:654–661.
30.
GabrielliWFMednickSA. Genetic correlates of criminal behavior. Am Behav Scientist1983;27:59–74.
31.
FitzhughKB. Some neuropsychological features of delinquent subjects. Percept Motor Skills1973;36:494.
32.
AndrewJM. Laterality on the Tapping Test among legal offenders. J Clin Child Psychol1978;7:149–150.
33.
KrynickiVE. Cerebral dysfunction in repetitively assaultive adolescents. J Nerv Ment Disease1978;166:59–67.
34.
HareRD. The Hare Psychopathy Checklist—Revised. Toronto Ontario: Multi-Health Systems; 1991.
35.
HareRD. Psychopaths and their nature: implications for the mental health and criminal justice systems. In: MillonTSimonsonEBurket-SmithMDavisR, (eds). Psychopathy: Antisocial, Criminal, and Violent Behavior. New York: Guilford Press; 1998.
36.
JohanssonPKerrMAndershedH. Linking adult psychopathy with childhood hyperactivity-impulsivity-attention problems and conduct problems through retrospective self-reports. J Pers Disorders2005;19(1):94–101.
37.
BabinskiLMHartsoughCSLambertNM. Childhood conduct problems, hyperactivity-impulsivity, and inattention as predictors of adult criminal activity. J Child Psychol Psychiat1999;40(3):347–355.
38.
SoubrieP. Reconciling the role of central serotonin neurones in human and animal behavior. Behav Brain Sciences1986;9:319–364.
39.
BrownGLGoodwinFKBallengerJC. Aggression in humans correlates with cerebrospinal fluid metabolite. Psychiat Res1979;1:131–139.
40.
LinnoilaMVirkkunenMScheininM. Low cerebrospinal fluid 5hydrodroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sciences1983;33:2609–2614.
41.
StoffDMPollockLVitielloB. Reduction of 3H-imipramine binding sites on platelets of conduct-disordered children. Neuropsychopharmacology1987;1:55–62.
42.
BirmaherBStanleyMGreenhillL. Platelet imipramine binding in children and adolescents with impulsive behavior. J Am Acad Child Adoles Psychiat1990;29:914–918.
43.
SalzmanCWolfsonANSchatzbergA. Effect of fluoxetine on anger in symptomatic volunteers with borderline personality disorder. J Clin Psychopharmacology1995;15:23–29.
44.
KavoussiRJLiuJCoccaroEF. Sertraline in the treatment of impulsive aggression in personality disordered patients. J Clin Psychiat1994;55:137–141.
45.
TomarkenAJDavidsonRJWheelerREDossRC. Individual differences in anterior brain asymmetry and fundamental dimensions of emotion. J Pers Soc Psychol1992;62:676–687.
46.
AratoMTekesKTothfalusiLMagyarKPalkovitsMFrecskaEReversed hemispheric asymmetry of imipramine binding in suicide victims. Biol Psychiat1991;29:699–702.
47.
DemeterETekesKMajorossyKPalkovitsMSoosMMagyarKThe asymmetry of 3H-imipramine binding may predict psychiatric illness. Life Sciences1989;44:1403–1410.
