The clinical utility of the EEG, especially in psychiatric, learning and cognitive disorders, has been greatly enhanced by the use of quantitative analysis (QEEG) and comparisons to a normative database. Of primary importance in the use of such a reference database are the following considerations and cautions: adequate sampling across a broad age range; consideration of inclusion/exclusion criteria; adequate sample of artifact-free data to demonstrate reliability and replicability of norms; demonstration of specificity and sensitivity. A normative database meeting these criteria allows the multivariate description of patterns of QEEG abnormalities in patients as compared to age appropriate normative values, and the exploration of neurophysiological heterogeneity within populations. Demonstrations of the clinical significance of this approach exist in the scientific literature and demonstrate that QEEG provides high sensitivity and specificity to abnormalities in brain function seen in psychiatric populations.
JohnERPrichepLSEastonP.Normative data banks and neurometrics: Basic concepts, methods and results of norm construction. In: GevinsASRemondA, (eds). Handbook of Electroencephalography and Clinical Neurophysiology. Amsterdam: Elsevier, 1987;1: 449–495.
GasserTBacherPMochsJ.Transformation towards the normal distribution of broadband spectral parameters of the EEG. Electroencephalogr Clin Neurophysiol1982;53(1):119–124.
4.
GlickSDRossmanKSteindorfSMaisonneuveIMCarlsonJNEffects and after-effects of Ibogaine on morphine self-administration in rats. Eur J Pharmacol1991;195:341–345.
5.
JohnERPrichepLSFriedmanJEastonP.Neurometrics: Computer assisted differential diagnosis of brain dysfunctions. Science1988;293:162–169.
6.
JohnERPrichepLSPrinciples of neurometrics and neurometric analysis of EEG and evoked potentials. In: NiedermeyerELopes daSilva F, (eds). EEG: Basic Principles, Clinical Applications and Related Fields. Baltimore: Williams and Wilkins, 1993: 989–1003.
7.
JohnERPrichepLSAhnHEastonPFridmanJKayeH.Neurometric evaluation of cognitive dysfunctions and neurological disorders in children. Prog Neurobiology1983;21:239–290.
8.
KondacsASzaboM.Long-term intra-individual variability of the background EEG in normals. Clin Neurophysiology1999;110:1708–1716.
9.
VerlegerRGasserTMocksJ.Corrections of EOG artifacts in event-related potentials in the EEG: Aspects of reliability and validity. Psychophysiol1982;19:472–480.
10.
JonkmanEJPoortvlietDCJVeeringMMDeWeerdAWJohnERThe use of neurometrics in the study of patients with cerebral ischemia. Electroencephalogr Clin Neurophysiol1985;61:333–341.
11.
AlvarezAPascualRValdesP.EEG development equations confirmed for Cuban school children. Electroencephalogr Clin Neurophysiol1987;67(4):330–332.
12.
de LeonDiaz AEHarmonyTMarosiEBeckerJAlvarezA.Effect of different factors on EEG spectral parameters. Intl J Neurosci1988;43:123–131.
13.
VeldhuizenRJJonkmanEJPoortvlietJDCSex differences in age regression parameters of healthy adults-normative data. Electroencephalogr Clin Neurophysiol1993;86(6):377–384.
14.
MatsuuraMOkuboYToruMKojimaTHeYHouYA cross-national study of children with emotional and behavioral problems: A WHO collaborative study in the Western Pacific Region. Biol Psychiatry1993;34:59–65.
15.
HughesJRJohnERConventional and quantitative electroencephalography in psychiatry. J Neuropsychiat Clin Neurosci1999;11(2):190–208.
16.
PrichepLSJohnERQEEG profiles of psychiatric disorders. Brain Topogr1992;4(4):249–257.
17.
DeslandesAVeigaHCagyMFiszmanAPiedadeRRibeiroP.Quantitative electroencephalography (QEEG) to discriminate primary degenerative dementia from major depressive disorder (depression). Arq Neuro-Psiquiatr2004;62(1):44–50.
18.
AfifiAClarkVAMayS.Computer-Aided Multivariate Analysis. Boca Raton: Chapman and Hall/CRC; 2004.
19.
ChabotRJMerkinHWoodLMDavenportTLSerfonteinG.Sensitivity and specificity of QEEG in children with attention deficit or specific developmental learning disorders. Clin Electroencephalogr1996;27(1):26–34.
20.
MonastraVJLubarJFLindenMVanDeusenPGreenGWingWAssessing attention deficit-hyperactivity disorder via quantitative electroencephalography: An initial validation study. Neuropsychology1999;13(3):424–433.
21.
LindauMJelicVJohanssonSEAndersenCWahlundLOAlmkvistO.Quantitative EEG abnormalities and cognitive dysfunctions in frontotemporal dementia and Alzheimer's disease. Dement Geriatr Cogn Disord2003;15(2):106–114.
22.
KnottVMahoneyCKennedySEvansK.EEG power, frequency, asymmetry, and coherence in male depression. Psychiat Res: Neuroimaging2001;106:123–140.
23.
PrichepLSAlperKKowalikSCJohnERMerkinHATomMQuantitative electroencephalographic characteristics of crack cocaine dependence. Biol Psychiat1996;40(10):986–993.
24.
WintererGKoppelBHeinzAZillerMDufeuPSchmidtLGQuantitative EEG (QEEG) predicts relapse in patients with chronic alcoholism and points to a frontality pronounced cerebral disturbance. Psychiat Res1998;78:101–113.
25.
KnottVBakishDLuskSBarkelyJPeruginiM.Quantitative EEG correlates of panic disorder. Psychiat Res1996;68:31–39.
26.
ThatcherRWWalkerRAGersonIGeislerFHEEG discriminant analyses of mild head trauma. Electroencephalogr Clin Neurophysiol1989;73:94–106.
27.
LlinasR.The intrinsic properties of mammalian neurons: Insights into central nervous system function. Science1988; 242:1654–1664.
Lopes daSilva F. Neural mechanisms underlying brain waves: From neural membranes to networks. Electroencephalogr Clin Neurophysiol1991;79:81–93.
30.
MichelAMLehmannDHenggelerBBrandeisD.Localization of the sources EEG delta, theta, and beta frequency bands using the FFT dipole approximation. Electroencephalogr Clin Neurophysiol1992;82:38–44.
31.
MichelCMHenggelerBBrandeisDLehmannD.Localization of sources of brain alpha/theta/delta activity and the influence of the mode of spontaneous mentation. Physiol Meas1993;14:21–26.
32.
SteriadeMGloorPLlinasRRLopes daSilva FHMesulamMMReport of IFCN Committee on Basic Mechanisms: Basic mechanisms of cerebral rhythmic activities. Electroencephalogr Clin Neurophysiol1990;76(6):481–508.
33.
PrichepLSMasFHollanderELiebowitzMJohnERAlmasMQuantitative electroencephalographic (QEEG) subtyping of obsessive compulsive disorder. Psychiat Res1993;50(1):25–32.
34.
HansenESPrichepLSBolwigTGJohnERQuantitative electroencephalography in OCD: Patients treated with paroxetine. Clin Electroencephalogr2003;34:70–74.
35.
PrichepLSAlperKRKowalikSCVaclavLMerkinHATomMPrediction of treatment outcome in cocaine dependent males using quantitative EEG. Drug Alc Depend1999;54(1):35–43.
36.
PrichepLSAlperKRSverdlovLKowalikSCJohnERMerkinHOutcome related electrophysiological subtypes of cocaine dependence. Clin Electroencephalogr2002;33(1):8–20.
37.
ChabotRJOrgillAACrawfordGHarrisMJSerfonteinG.Behavioral and electrophysiological predictors of treatment response stimulants in children with attention disorders. J Child Neurology1999;14(6):343–351.
38.
PrichepLSJohnERNeurometric studies of methylphenidate responders and non-responders. In: PavlidisGT, (ed). Perspectives on Dyslexia. New York, NY: John Wiley and Sons, 1990;1: 133–139.
39.
SuffinSCEmoryWHNeurometric subgroups in attentional and affective disorders and their association with pharmacotherapeutic outcome. Clin Electroencephalogr1995;26(2): 76–83.
40.
NickelsenTLufkinEGRiggsBLCoxDACookTHRaloxifene hydrochloride, a selective estrogen receptor modulator: Safety assessment of effects on cognitive and mood in postmenopausal women. Psychoneuroendocrinology1999;24:115–128.
41.
CookIALeuchterAFMorganMWitteEStubbemanWFAbramsMTEarly changes in prefrontal activity characterize clinical responders to antidepressants. Neuropsychopharmacology2002;27(1):120–131.
42.
PizzagalliDPascual-MarquiRNitschkeJBOakesTRLarsonCLAbercrombieHCAnterior cingulate activity as a predictor of degree of treatment response in major depression: Evidence from brain electrical tomography analysis. Am J Psychiatry2001;158:405–415.
43.
PrichepLSJohnEREssig-PeppardTAlperKRNeurometric subtyping of depressive disorders. In: CazzulloCLInvernizziGSacchettiEVitaA, (eds). Plasticity and Morphology of the CNS. London: M.T.P. Press; 1990.
44.
CzoborPVolavkaJ.Pretreatment EEG predicts short-term response to haloperidol treatment. Biol Psychiat1991;30:927–942.
45.
JohnERPrichepLSAlperKRMasFCancroREastonPQuantitative electrophysiological characteristics and subtyping of schizophrenia. Biol Psychiat1994;36:801–826.
