Purpose: To compare depression risk among vertically HIV-infected adolescents and matched controls in northern Thailand. Methods: The Thai Children’s Depression Inventory (CDI) was administered among vertically HIV-infected adolescents and matched controls in northern Thailand from 2007 to 2008, as part of a comprehensive quantitative survey that also assessed demographics, substance use, and sexual behavior and knowledge. A total CDI score ≥15 was considered a positive screen for possible depression. Results: A total of 54 cases and 165 controls participated; cases had significantly lower mean CDI scores (P = .003) and fewer screened positive for possible depression (P = .046). Cases who screened positive were more likely to have engaged in sexual intercourse (P = .07). Conclusions: Depressive symptoms and depression risk were reduced among vertically HIV-infected adolescents compared to matched controls in northern Thailand. Further investigation into mental health disorders among vertically HIV-infected adolescents in developing settings is needed.
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