Several studies have reported positive associations between oral infections and systemic diseases. The purpose of the present study was to evaluate the effects of oral symptoms on mortality from cardiovascular disease (CVD) and pneumonia. Using data from a cohort study in Japan, we analyzed 4,139 individuals aged 40–79 years. The baseline questionnaire included the following items related to oral symptoms: ‘sensitive teeth’, ‘difficulty in chewing tough food substances’, ‘bleeding gums’, and ‘mouth feels sticky’. We used the Cox proportional hazard model to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs) for mortality, after adjustments for lifestyle, socio-economic factors, and history of diseases. Persons complaining that their ‘mouth feels sticky’ had a two-fold higher risk of pneumonia (HR = 2.1; 95%CI, 1.2–3.6), while those complaining of ‘sensitive teeth’ had a lower risk of CVD (HR = 0.4; 95%CI, 0.2–0.9). Some oral symptoms may be predictors of mortality from pneumonia and CVD.
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References
1.
Abnet CC, Qiao YL, Dawsey SM, Dong ZW, Taylor PR, Mark SD -2005-. Tooth loss is associated with increased risk of total death and death from upper gastrointestinal cancer, heart disease, and stroke in a Chinese population-based cohort. Int J Epidemiol34:467–474.
2.
Ajwani S, Mattila KJ, Närhi TO, Tilvis RS, Ainamo A -2003-. Oral health status, C-reactive protein and mortality—a 10 year follow-up study. Gerodontology20:32–40.
3.
Amar S, Han X -2003-. The impact of periodontal infection on systemic diseases. Med Sci Monit9:291–299.
4.
Azarpazhooh A, Leake JL -2006-. Systematic review of the association between respiratory diseases and oral health. J Periodontol77:1465–1482.
5.
Benyamini Y, Leventhal H, Leventhal EA -2004-. Self-rated oral health as an independent predictor of self-rated general health, self-esteem and life satisfaction. Soc Sci Med59:1109–1116.
6.
Daly RM, Elsner RJ, Allen PF, Burke FM -2003-. Associations between self-reported dental status and diet. J Oral Rehabil30:964–970.
7.
DeSalvo KB, Bloser N, Reynolds K, He J, Muntner P -2006-. Mortality prediction with a single general self-rated health question. A meta-analysis. J Gen Intern Med21:267–275.
8.
Fujino Y, Mizoue T, Tokui N, Yoshimura T -2001-. Prospective study of diabetes mellitus and liver cancer in Japan. Diabetes Metab Res Rev17:374–379.
9.
Fujino Y, Mizoue T, Tokui N, Yoshimura T -2002-. A prospective study of blood transfusion history and liver cancer in a high-endemic area of Japan. Transfus Med12:297–302.
10.
Hamalainen P, Meurman JH, Keskinen M, Heikkinen E -2003-. Relationship between dental health and 10-year mortality in a cohort of community-dwelling elderly people. Eur J Oral Sci111:291–296.
11.
Hamalainen P, Meurman JH, Kauppinen M, Keskinen M -2005-. Oral infections as predictors of mortality. Gerodontology22:151–157.
12.
Health Service Bureau, Ministry of Health and Welfare, Japan -1989-. Report on the survey of dental disease -1987-. Tokyo: Oral Health Association.
13.
Ikebe K, Matsuda K, Morii K, Furuya-Yoshinaka M, Nokubi T, Renner RP -2006-. Association of masticatory performance with age, posterior occlusal contacts, occlusal force, and salivary flow in older adults. Int J Prosthodont19:475–481.
14.
Janket SJ, Baird AE, Chuang SK, Jones JA -2003-. Meta-analysis of periodontal disease and risk of coronary heart disease and stroke. Oral Surg Oral Med Oral Pathol Oral Radiol Endod95:559–569.
15.
Janssens JP -2005-. Pneumonia in the elderly -geriatric- population. Curr Opin Pulm Med11:226–230.
16.
Jansson L, Lavstedt S, Frithiof L -2002-. Relationship between oral health and mortality rate. J Clin Periodontol29:1029–1034.
17.
Khader YS, Albashaireh ZS, Alomari MA -2004-. Periodontal diseases and the risk of coronary heart and cerebrovascular diseases: a meta-analysis. J Periodontol75:1046–1053.
18.
Mizoue T, Tokui N, Nishisaka K, Nishisaka S, Ogimoto I, Ikeda M, et al. -2000-. Prospective study on the relation of cigarette smoking with cancer of the liver and stomach in an endemic region. Int J Epidemiol29:232–237.
19.
Ngoan LT, Mizoue T, Fujino Y, Tokui N, Yoshimura T -2002-. Dietary factors and stomach cancer mortality. Br J Cancer87:37–42.
20.
Ozagar A, Dede F, Turoglu T, Uneri C -2000-. Aspiration of nasal secretions into the lungs in patients with acute sinonasal infections. Laryngoscope110:107–110.
21.
Pham TM, Fujino Y, Ide R, Kubo T, Shirane K, Tokui N, et al. -2006-. Prospective study of vegetable consumption and liver cancer in Japan. Int J Cancer119:2408–2411.
22.
Scannapieco FA -1999-. Role of oral bacteria in respiratory infection. J Periodontol70:793–802.
23.
Sheiham A, Steele JG, Marcenes W, Finch S, Walls AW -1999-. The impact of oral health on stated ability to eat certain foods; findings from the National Diet and Nutrition Survey of Older People in Great Britain. Gerodontology16:11–20.
24.
Tamakoshi A, Yoshimura T, Inaba Y, Ito Y, Watanabe Y, Fukuda K, et al. -2005-. Profile of the JACC study. J Epidemiol15-Suppl 1-:4–8.
25.
Thomson WM, Chalmers JM, Spencer AJ, Slade GD, Carter KD -2006-. A longitudinal study of medication exposure and xerostomia among older people. Gerodontology23:205–213.
26.
Tonetti MS, D’Aiuto F, Nibali L, Donald A, Storry C, Parkar M, et al. -2007-. Treatment of periodontitis and endothelial function. N Engl J Med356:911–920.
27.
Tuominen R, Reunanen A, Paunio M, Paunio I, Aromaa A -2003-. Oral health indicators poorly predict coronary heart disease deaths. J Dent Res82:713–718.
28.
Utoguchi K, Nishisaka S, Tokui N, Mizoue T, Ogimoto I, Yoshimura T -1997-. Association between self-reported stressful feeling by SACL and mortality in a Japanese community. J Epidemiol7:9–16.
