Evidence of the effects of various sealant and fluoride materials in stabilizing or reversing incipient caries lesions has been reported. However, a knowledge gap still exists as to what material yields the best results. Thus, the objective of this study was to find the most effective material by comparing the effects of a resin-based sealant (sealant), a fluoride-containing sealant (F-sealant), a fluoride varnish (F-varnish), and a glass-ionomer cement (GIC) on deremineralization of incipient artificial caries and adjacent intact enamel on proximal surfaces of posterior teeth. The 4 materials were applied to lesions created on proximal surfaces. Areas of intact enamel 0.5 mm adjacent to the materials were also studied. The specimens were thermo- and pH-cycled. Cross-sections of the two areas were analyzed under polarized light microscope and quantified with Image-Pro plus®. The most effective material in reducing the carious areas was GIC, followed by F-varnish, F-sealant, and sealants. GIC followed by F-varnish was most efficient in inhibiting new caries lesions 0.5 mm adjacent to the materials.
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